Itch Mechanisms and Circuits

Monkey See, Monkey Do: Contagious Itch in Nonhuman Primates

(2016) A Feneran et al.   ACTA DERMATO-VENEREOLOGICA

Opioid Modulation of Facial Itch- and Pain-related Responses and Grooming Behavior in Rats

(2013) J Spradley et al.   ACTA DERMATO-VENEREOLOGICA

Neuropathic itch: diagnosis and management

(2013) Astrid Stumpf et al.   Dermatologic Therapy

Sensitivity to itch and pain in patients with psoriasis and rheumatoid arthritis

(2013) Antoinette I. M. van Laarhoven et al.   EXPERIMENTAL DERMATOLOGY

Potentiation of the Transient Receptor Potential Vanilloid 1 Channel Contributes to Pruritogenesis in a Rat Model of Liver Disease

(2013) Majedeline Belghiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of the Gastrin-Releasing Peptide in Cutaneous Nerve Fibers and Its Receptor in the Spinal Cord in Primates with Chronic Itch

(2013) Leigh A. Nattkemper et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Ion Channel TRPA1 Is Required for Chronic Itch

(2013) S. R. Wilson et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

(2013) David P Roberson et al.   NATURE NEUROSCIENCE

Excitatory Superficial Dorsal Horn Interneurons Are Functionally Heterogeneous and Required for the Full Behavioral Expression of Pain and Itch

(2013) Xidao Wang et al.   NEURON

Mechanically evoked itch in humans

(2013) Miyuki Fukuoka et al.   PAIN

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Common Neuropathic Itch Syndromes

(2012) AL Oaklander   ACTA DERMATO-VENEREOLOGICA

Can itch-related visual stimuli alone provoke a scratch response in healthy individuals?

(2012) D.M. Lloyd et al.   BRITISH JOURNAL OF DERMATOLOGY

Psychosomatic factors in pruritus

(2012) Hong Liang Tey et al.   CLINICS IN DERMATOLOGY

Pruritus in Chronic Cholestatic Liver Disease

(2012) Chalermrat Bunchorntavakul et al.   Clinics in Liver Disease

Cathepsin E induces itch-related response through the production of endothelin-1 in mice

(2012) Tsugunobu Andoh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Increased frequencies of IL-31-producing T cells are found in chronic atopic dermatitis skin

(2012) Krisztina Szegedi et al.   EXPERIMENTAL DERMATOLOGY

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Mouse Model of Touch-Evoked Itch (Alloknesis)

(2012) Tasuku Akiyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

NGF Sensitizes Nociceptors for Cowhage- but Not Histamine-Induced Itch in Human Skin

(2012) Roman R. Rukwied et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate

(2012) Steve Davidson et al.   JOURNAL OF NEUROPHYSIOLOGY

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Imiquimod Enhances Excitability of Dorsal Root Ganglion Neurons by Inhibiting Background (K2P) and Voltage-Gated (Kv1.1 and Kv1.2) Potassium Channels

(2012) Jaekwang Lee et al.   Molecular Pain

The Majority of Dorsal Spinal Cord Gastrin Releasing Peptide is Synthesized Locally Whereas Neuromedin B is Highly Expressed in Pain- and Itch-Sensing Somatosensory Neurons

(2012) Michael S Fleming et al.   Molecular Pain

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

IL-31 significantly correlates with disease activity and Th2 cytokine levels in children with atopic dermatitis

(2012) Ulrike Raap et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Neural basis of contagious itch and why some people are more prone to it

(2012) H. Holle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapy of Human Papillomavirus-Related Disease

(2012) Peter L. Stern et al.   VACCINE

Contagious itch in humans: a study of visual ‘transmission’ of itch in atopic dermatitis and healthy subjects

(2011) A.D.P. Papoiu et al.   BRITISH JOURNAL OF DERMATOLOGY

Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids

(2011) Xian-Yu Liu et al.   CELL

The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons

(2011) Lishi Li et al.   CELL

Signaling by IL-31 and functional consequences

(2011) Christian Cornelissen et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Molecular signaling of pruritus induced by endothelin-1 in mice

(2011) Jiexian Liang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Histamine and H1-antihistamines: Celebrating a century of progress

(2011) F. Estelle R. Simons et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice

(2011) Nari Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Uremic pruritus

(2011) Lara W. Kfoury et al.   JOURNAL OF NEPHROLOGY

Enhanced responses of lumbar superficial dorsal horn neurons to intradermal PAR-2 agonist but not histamine in a mouse hindpaw dry skin itch model

(2011) Tasuku Akiyama et al.   JOURNAL OF NEUROPHYSIOLOGY

In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans

(2011) C. Ma et al.   JOURNAL OF NEUROPHYSIOLOGY

A Role for Nociceptive, Myelinated Nerve Fibers in Itch Sensation

(2011) M. Ringkamp et al.   JOURNAL OF NEUROSCIENCE

BAM8-22 Peptide Produces Itch and Nociceptive Sensations in Humans Independent of Histamine Release

(2011) P. Sikand et al.   JOURNAL OF NEUROSCIENCE

Glutamate Acts as a Neurotransmitter for Gastrin Releasing Peptide-Sensitive and Insensitive Itch-Related Synaptic Transmission in Mammalian Spinal Cord

(2011) Kohei Koga et al.   Molecular Pain

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch

(2011) Alexandru D.P. Papoiu et al.   NEUROIMAGE

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathic Itch

(2011) Anne Louise Oaklander   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

Biology of mammalian bombesin-like peptides and their receptors

(2011) Ishita D Majumdar et al.   Current Opinion in Endocrinology Diabetes and Obesity

Signal transduction by protease-activated receptors

(2010) Unice JK Soh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

(2010) Andreas E. Kremer et al.   GASTROENTEROLOGY

Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis

(2010) Stefanie Haas et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Cathepsin S Elicits Itch and Signals via Protease-Activated Receptors

(2010) Vemuri B. Reddy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Facial Injections of Pruritogens and Algogens Excite Partly Overlapping Populations of Primary and Second-Order Trigeminal Neurons in Mice

(2010) T. Akiyama et al.   JOURNAL OF NEUROPHYSIOLOGY

Inhibition of Inflammatory Pain by Activating B-Type Natriuretic Peptide Signal Pathway in Nociceptive Sensory Neurons

(2010) F.-X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptor 7 mediates pruritus

(2010) Tong Liu et al.   NATURE NEUROSCIENCE

VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

(2010) Yang Liu et al.   NEURON

VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

(2010) Malin C. Lagerström et al.   NEURON

An Itch To Be Scratched

(2010) Kush N. Patel et al.   NEURON

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

(2010) Sarah E. Ross et al.   NEURON

Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats

(2010) Earl E. Carstens et al.   NEUROREPORT

Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model

(2010) Tasuku Akiyama et al.   NEUROSCIENCE LETTERS

Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch

(2010) T. Akiyama et al.   PAIN

Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy

(2010) Sonja Ständer et al.   PLoS One

Aprepitant against pruritus in patients with solid tumours

(2010) Bruno Vincenzi et al.   SUPPORTIVE CARE IN CANCER

Protease and Protease-Activated Receptor-2 Signaling in the Pathogenesis of Atopic Dermatitis

(2010) Sang Eun Lee et al.   YONSEI MEDICAL JOURNAL

Gentle Cleansing and Moisturizing for Patients with Atopic Dermatitis and Sensitive Skin

(2009) Wai Kwong Cheong   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Role of neurotrophin signalling in the differentiation of neurons from dorsal root ganglia and sympathetic ganglia

(2009) Uwe Ernsberger   CELL AND TISSUE RESEARCH

Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis

(2009) Kenichiro Tsujii et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis

(2009) Maki Ozawa et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons

(2009) Steve Davidson et al.   NATURE NEUROSCIENCE

Skin problems in chronic kidney disease

(2009) Dirk RJ Kuypers   Nature Reviews Nephrology

Similar itch and nociceptive sensations evoked by punctate cutaneous application of capsaicin, histamine and cowhage

(2009) Parul Sikand et al.   PAIN

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

(2009) N. Imamachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

Personality characteristics in chronic and non-chronic allergic conditions

(2008) A. Buske-Kirschbaum et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuropathic and psychogenic itch

(2008) Gil Yosipovitch et al.   Dermatologic Therapy

Histamine H4receptor antagonism reduces hapten-induced scratching behaviour but not inflammation

(2008) Kristine Roßbach et al.   EXPERIMENTAL DERMATOLOGY

Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis

(2008) Øystein Grimstad et al.   EXPERIMENTAL DERMATOLOGY

Animal Models of Atopic Dermatitis

(2008) Haoli Jin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Separate Peripheral Pathways for Pruritus in Man

(2008) Barbara Namer et al.   JOURNAL OF NEUROPHYSIOLOGY

A Role for Polymodal C-Fiber Afferents in Nonhistaminergic Itch

(2008) L. M. Johanek et al.   JOURNAL OF NEUROSCIENCE

Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors

(2008) V. B. Reddy et al.   JOURNAL OF NEUROSCIENCE

Behavioral differentiation between itch and pain in mouse

(2008) Steven G. Shimada et al.   PAIN

Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice

(2007) Dae-Kwon Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY