Development of Novel Pt(IV)-Carbohydrate Derivatives as Targeted Anticancer Agents against Osteosarcoma

Platinum-based drugs for cancer therapy and anti-tumor strategies

(2022) Chunyu Zhang et al.   Theranostics

A platinum(IV) prodrug strategy to overcome glutathione-based oxaliplatin resistance

(2022) Philipp Fronik et al.   Communications Chemistry

Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism

(2022) Milja Arponen et al.   Frontiers in Physiology

The Mechanism of Warburg Effect-Induced Chemoresistance in Cancer

(2021) Chang Liu et al.   Frontiers in Oncology

Click Pt(IV)-Carbohydrates Pro-Drugs for Treatment of Osteosarcoma

(2021) Eoin Moynihan et al.   Frontiers in Chemistry

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

(2020) Dongqing Zheng et al.   JOURNAL OF CELL SCIENCE

Structure, function and regulation of mammalian glucose transporters of the SLC2 family

(2020) Geoffrey D. Holman   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

(2020) Sandra Valle et al.   Nature Communications

Overcoming Limitations of Cisplatin Therapy by Additional Treatment With the HSP90 Inhibitor Onalespib

(2020) Anja Charlotte Lundgren Mortensen et al.   Frontiers in Oncology

Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche

(2020) Giada Bassi et al.   Scientific Reports

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Differences in osteogenic induction of human mesenchymal stem cells between a tailored 3D hybrid scaffold and a 2D standard culture

(2019) Samuele M. Dozio et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Evaluation of different crosslinking agents on hybrid biomimetic collagen-hydroxyapatite composites for regenerative medicine

(2018) Gopal Shankar Krishnakumar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Protected and De-protected Platinum(IV) Glycoconjugates With GLUT1 and OCT2-Mediated Selective Cancer Targeting: Demonstrated Enhanced Transporter-Mediated Cytotoxic Properties in vitro and in vivo

(2018) Jing Ma et al.   Frontiers in Chemistry

Mono-functionalized glycosylated platinum(IV) complexes possessed both pH and redox dual-responsive properties: Exhibited enhanced safety and preferentially accumulated in cancer cells in vitro and in vivo

(2017) Jing Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery

(2017) Jing Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

(2017) Marie-Françoise Heymann et al.   CELLULAR IMMUNOLOGY

Design, synthesis and biological evaluation of a novel series of glycosylated platinum(iv) complexes as antitumor agents

(2016) Qingpeng Wang et al.   DALTON TRANSACTIONS

Glycosylated platinum(iv) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects

(2016) Jing Ma et al.   DALTON TRANSACTIONS

Chemical Approach to Positional Isomers of Glucose–Platinum Conjugates Reveals Specific Cancer Targeting through Glucose-Transporter-Mediated Uptake in Vitro and in Vivo

(2016) Malay Patra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors

(2016) Kapil Upadhyaya et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(iv) prodrug with unique mode of action

(2015) Lili Ma et al.   CHEMICAL COMMUNICATIONS

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells

(2011) Manuel Cifuentes et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Satraplatin: leading the new generation of oral platinum agents

(2009) Ashish Bhargava et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS