Click Pt(IV)-Carbohydrates Pro-Drugs for Treatment of Osteosarcoma

Uptake of fluorescent d- and l-glucose analogues, 2-NBDG and 2-NBDLG, into human osteosarcoma U2OS cells in a phloretin-inhibitable manner

(2021) Tetsuya Ogawa et al.   Human Cell

AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

(2020) Dongqing Zheng et al.   JOURNAL OF CELL SCIENCE

Exploiting azide–alkyne click chemistry in the synthesis, tracking and targeting of platinum anticancer complexes

(2020) Nicola J. Farrer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors

(2020) Teresa Lauria et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pt(IV) pro-drugs with an axial HDAC inhibitor demonstrate multimodal mechanisms involving DNA damage and apoptosis independent of cisplatin resistance in A2780/A2780cis cells

(2020) Awatif Rashed Z. Almotairy et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

(2020) Sandra Valle et al.   Nature Communications

Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche

(2020) Giada Bassi et al.   Scientific Reports

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

(2019) Reece G. Kenny et al.   CHEMICAL REVIEWS

Osteopontin as a biomarker for osteosarcoma therapy and prognosis (Review)

(2019) Xingwen Han et al.   Oncology Letters

Synthesis and cytotoxicity evaluation of glycosidic derivatives of lawsone against breast cancer cell lines

(2019) Flaviano M. Ottoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Increased immune cell infiltration in patient-derived tumor explants treated with Traniplatin: an original Pt(iv) pro-drug based on Cisplatin and Tranilast

(2018) Daniele Lo Re et al.   CHEMICAL COMMUNICATIONS

Development of an Efficient Dual-Action GST-Inhibiting Anticancer Platinum(IV) Prodrug

(2018) Keefe Guang Zhi Lee et al.   ChemMedChem

Dual-acting antitumor Pt(iv) prodrugs of kiteplatin with dichloroacetate axial ligands

(2018) Salvatore Savino et al.   DALTON TRANSACTIONS

Synthesis and antiproliferative activity of flavonoid triazolyl glycosides

(2018) Gang-qiang Wang et al.   HETEROCYCLIC COMMUNICATIONS

TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma

(2018) Cuiyun Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance

(2018) Emanuele Petruzzella et al.   Chemical Science

Protected and De-protected Platinum(IV) Glycoconjugates With GLUT1 and OCT2-Mediated Selective Cancer Targeting: Demonstrated Enhanced Transporter-Mediated Cytotoxic Properties in vitro and in vivo

(2018) Jing Ma et al.   Frontiers in Chemistry

A Pt(IV) Prodrug Combining Chlorambucil and Cisplatin: a Dual-Acting Weapon for Targeting DNA in Cancer Cells

(2018) Diego Montagner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mono-functionalized glycosylated platinum(IV) complexes possessed both pH and redox dual-responsive properties: Exhibited enhanced safety and preferentially accumulated in cancer cells in vitro and in vivo

(2017) Jing Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Microtubules in 3D cell motility

(2017) Benjamin P. Bouchet et al.   JOURNAL OF CELL SCIENCE

Glycosylated Platinum(IV) Complexes as Substrates for Glucose Transporters (GLUTs) and Organic Cation Transporters (OCTs) Exhibited Cancer Targeting and Human Serum Albumin Binding Properties for Drug Delivery

(2017) Jing Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

(2017) Marie-Françoise Heymann et al.   CELLULAR IMMUNOLOGY

Platinum(iv) anticancer prodrugs – hypotheses and facts

(2016) Dan Gibson   DALTON TRANSACTIONS

Glycosylated platinum(iv) prodrugs demonstrated significant therapeutic efficacy in cancer cells and minimized side-effects

(2016) Jing Ma et al.   DALTON TRANSACTIONS

Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer

(2016) Meng Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Establishment and characterization of a novel osteosarcoma cell line: CHOS

(2016) Yunlu Liu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Chemical Approach to Positional Isomers of Glucose–Platinum Conjugates Reveals Specific Cancer Targeting through Glucose-Transporter-Mediated Uptake in Vitro and in Vivo

(2016) Malay Patra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer stem cell metabolism: a potential target for cancer therapy

(2016) Abhijeet Deshmukh et al.   Molecular Cancer

Identification of gallic acid based glycoconjugates as a novel tubulin polymerization inhibitors

(2016) Kapil Upadhyaya et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(iv) prodrug with unique mode of action

(2015) Lili Ma et al.   CHEMICAL COMMUNICATIONS

Azide vs Alkyne Functionalization in Pt(II) Complexes for Post-treatment Click Modification: Solid-State Structure, Fluorescent Labeling, and Cellular Fate

(2015) Regina Wirth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of a series of glucosyl triazole derivatives and their self-assembling properties

(2015) Hari P.R. Mangunuru et al.   TETRAHEDRON LETTERS

On the Stability of PtIVPro-Drugs with Haloacetato Ligands in the Axial Positions

(2014) Ezequiel Wexselblatt et al.   CHEMISTRY-A EUROPEAN JOURNAL

Copper-Free Click-Chemistry Platform to Functionalize Cisplatin Prodrugs

(2014) Rakesh K. Pathak et al.   CHEMISTRY-A EUROPEAN JOURNAL

Conjugates of Cisplatin and Cyclooxygenase Inhibitors as Potent Antitumor Agents Overcoming Cisplatin Resistance

(2014) Wilma Neumann et al.   ChemMedChem

1,2,3-Triazoles as Amide Bond Mimics: Triazole Scan Yields Protease-Resistant Peptidomimetics for Tumor Targeting

(2013) Ibai E. Valverde et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Functional characterisation of osteosarcoma cell lines and identification of mRNAs and miRNAs associated with aggressive cancer phenotypes

(2013) S U Lauvrak et al.   BRITISH JOURNAL OF CANCER

Monofunctional and Higher-Valent Platinum Anticancer Agents

(2013) Timothy C. Johnstone et al.   INORGANIC CHEMISTRY

Facile Preparation of Mono-, Di- and Mixed-Carboxylato Platinum(IV) Complexes for Versatile Anticancer Prodrug Design

(2012) Jenny Z. Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Insulin regulates GLUT1-mediated glucose transport in MG-63 human osteosarcoma cells

(2011) Manuel Cifuentes et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XII Inhibitors

(2011) Jason C. Morris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advances in Platinum Chemotherapeutics

(2010) Benjamin W. Harper et al.   CHEMISTRY-A EUROPEAN JOURNAL