Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation

Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.

(2021) Faik Imeri et al.   MATRIX BIOLOGY

Dimethylamine enhances platelet hyperactivity in chronic kidney disease model

(2021) Yongning Gao et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Impaired respiratory burst contributes to infections in PKCδ-deficient patients

(2021) Anna-Lena Neehus et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo

(2021) Bisera Stepanovska Tanturovska et al.   MOLECULES

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile

(2021) Anna Katharina Spohner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge

(2020) Bisera Stepanovska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein Kinase C-δ Mediates Kidney Tubular Injury in Cold Storage–Associated Kidney Transplantation

(2020) Jiefu Zhu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene

(2020) Guangbi Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Podocytopathies

(2020) Jeffrey B. Kopp et al.   Nature Reviews Disease Primers

Fifty years of lyase and a moment of truth: Sphingosine phosphate lyase from discovery to disease

(2019) Julie D. Saba   JOURNAL OF LIPID RESEARCH

Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter

(2019) Taketoshi Kajimoto et al.   Science Signaling

Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases

(2019) Bisera Stepanovska et al.   PHARMACOLOGICAL RESEARCH

A Review of Podocyte Biology

(2018) Puneet Garg   AMERICAN JOURNAL OF NEPHROLOGY

Protein kinase C: perfectly balanced

(2018) Alexandra C. Newton   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

IL-6 increases podocyte motility via MLC-mediated focal adhesion impairment and cytoskeleton disassembly

(2018) Fang-Fang He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Sphingolipid signaling in renal fibrosis

(2018) Andrea Huwiler et al.   MATRIX BIOLOGY

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and Beyond

(2018) Claire E. Martin et al.   Frontiers in Endocrinology

Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications

(2017) Andreas R. Janecke et al.   HUMAN MUTATION

“Dicing and Splicing” Sphingosine Kinase and Relevance to Cancer

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

(2017) Rathi Prasad et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency

(2017) Svjetlana Lovric et al.   JOURNAL OF CLINICAL INVESTIGATION

N-Degradomic Analysis Reveals a Proteolytic Network Processing the Podocyte Cytoskeleton

(2017) Markus M. Rinschen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

(2017) Hua Su et al.   Frontiers in Immunology

Exploring the genetic basis of early-onset chronic kidney disease

(2016) Asaf Vivante et al.   Nature Reviews Nephrology

Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions

(2016) Mathias J. Gerl et al.   PLoS One

Protein Kinase C Isoforms Differentially Regulate Hypoxia-Inducible Factor-1α Accumulation in Cancer Cells

(2015) Hyunju Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation

(2015) Jens Schümann et al.   TOXICOLOGIC PATHOLOGY

Tuning the signalling output of protein kinase C

(2014) Corina E. Antal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand

(2014) Osamu Ichii et al.   PLoS One

Glomerular VEGF resistance induced by PKCδ/SHP-1 activation and contribution to diabetic nephropathy

(2012) Akira Mima et al.   FASEB JOURNAL

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(2011) Hadi Falahatpisheh et al.   MOLECULAR MEDICINE

PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism

(2011) Florence Bourquin et al.   PROTEIN SCIENCE

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking

(2010) Maria L. Allende et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKC-  Promotes Renal Tubular Cell Apoptosis Associated with Proteinuria

(2010) X. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis

(2010) Irini Tossidou et al.   PLoS One

New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

(2008) Andrea Huwiler et al.   BIOCHEMICAL PHARMACOLOGY