ST-2191, an Anellated Bismorpholino Derivative of Oxy-Fingolimod, Shows Selective S1P1 Agonist and Functional Antagonist Potency In Vitro and In Vivo

Novel compounds with dual S1P receptor agonist and histamine H3 receptor antagonist activities act protective in a mouse model of multiple sclerosis

(2021) Faik Imeri et al.   NEUROPHARMACOLOGY

Suppressive Effect of CYM50358 S1P4 Antagonist on Mast Cell Degranulation and Allergic Asthma in Mice

(2021) Wi-Jin Jeon et al.   Biomolecules & Therapeutics

Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Agonist

(2021) Sekhar Surapaneni et al.   DRUG METABOLISM AND DISPOSITION

Loss of sphingosine kinase 2 enhances Wilm's tumor suppressor gene 1 and nephrin expression in podocytes and protects from streptozotocin-induced podocytopathy and albuminuria in mice.

(2021) Faik Imeri et al.   MATRIX BIOLOGY

Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge

(2020) Bisera Stepanovska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Morpholino Analogues of Fingolimod as Novel and Selective S1P1 Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis

(2020) Bisera Stepanovska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sphingosine 1-phosphate Receptor Modulator Therapy for Multiple Sclerosis: Differential Downstream Receptor Signalling and Clinical Profile Effects

(2020) Jerold Chun et al.   DRUGS

Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases

(2019) Bisera Stepanovska et al.   PHARMACOLOGICAL RESEARCH

Amiselimod (MT-1303), a Novel Sphingosine 1-Phosphate Receptor-1 Modulator, Potently Inhibits the Progression of Lupus Nephritis in Two Murine SLE Models

(2019) Kunio Sugahara et al.   Journal of Immunology Research

Internalization of G-protein-coupled receptors: Implication in receptor function, physiology and diseases

(2018) Davide Calebiro et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Abnormal islet sphingolipid metabolism in type 1 diabetes

(2018) Laurits J. Holm et al.   DIABETOLOGIA

The sphingosine 1-phosphate receptor modulator fingolimod as a therapeutic agent: Recent findings and new perspectives

(2018) Andrea Huwiler et al.   PHARMACOLOGY & THERAPEUTICS

Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1) and receptor-5 (S1P5) agonist with autoimmune disease-modifying activity

(2016) F L Scott et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sphingosine kinase 2 deficient mice exhibit reduced experimental autoimmune encephalomyelitis: Resistance to FTY720 but not ST-968 treatments

(2016) Faik Imeri et al.   NEUROPHARMACOLOGY

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

(2014) Yasuyuki Kihara et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel oxazolo-oxazole derivatives of FTY720 reduce endothelial cell permeability, immune cell chemotaxis and symptoms of experimental autoimmune encephalomyelitis in mice

(2014) Faik Imeri et al.   NEUROPHARMACOLOGY

Desensitization by Progressive Up-Titration Prevents First-Dose Effects on the Heart: Guinea Pig Study with Ponesimod, a Selective S1P1 Receptor Modulator

(2013) Markus Rey et al.   PLoS One

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate

(2012) P Gergely et al.   BRITISH JOURNAL OF PHARMACOLOGY

Clinical immunology of the sphingosine 1-phosphate receptor modulator fingolimod (FTY720) in multiple sclerosis

(2011) M. Mehling et al.   NEUROLOGY

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Efficient chromatography-free synthesis of the oxy-analogue of fingolimod

(2010) Aleksandra Zivkovic et al.   TETRAHEDRON LETTERS

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

(2008) Andrea Huwiler et al.   BIOCHEMICAL PHARMACOLOGY

Update of the LIPID MAPS comprehensive classification system for lipids

(2008) Eoin Fahy et al.   JOURNAL OF LIPID RESEARCH