PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism

The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner

(2011) Ashok Kumar et al.   CELLULAR SIGNALLING

Role of a conserved arginine residue during catalysis in serine palmitoyltransferase

(2011) Jonathan Lowther et al.   FEBS LETTERS

Sphingosine 1-phosphate (S1P): Physiology and the effects of S1P receptor modulation

(2011) T. Hla et al.   NEUROLOGY

S1P lyase regulates DNA damage responses through a novel sphingolipid feedback mechanism

(2011) A Kumar et al.   Cell Death & Disease

Mutations in the SPTLC2 Subunit of Serine Palmitoyltransferase Cause Hereditary Sensory and Autonomic Neuropathy Type I

(2010) Annelies Rotthier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

S1P metabolism in cancer and other pathological conditions

(2010) Weng In Leong et al.   BIOCHIMIE

The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein

(2010) Marine C. C. Raman et al.   BIOPOLYMERS

Ceramide kinase: The first decade

(2010) Frédéric Bornancin   CELLULAR SIGNALLING

Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C

(2010) Hitoshi Ikeda et al.   CLINICA CHIMICA ACTA

A Disease-causing Mutation in the Active Site of Serine Palmitoyltransferase Causes Catalytic Promiscuity

(2010) Kenneth Gable et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids

(2010) Anke Penno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking

(2010) Maria L. Allende et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Deoxysphingoid bases as plasma markers in Diabetes mellitus

(2010) Mariana Bertea et al.   Lipids in Health and Disease

Ceramide and ceramide 1-phosphate in health and disease

(2010) Lide Arana et al.   Lipids in Health and Disease

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

(2010) Jonathan Lowther et al.   Molecular BioSystems

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine

(2010) D. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine  -synthase

(2010) M. Koutmos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease

(2010) Patricia Gangoiti et al.   PROGRESS IN LIPID RESEARCH

Structure and Function of Sphingosine-1-Phosphate Lyase, a Key Enzyme of Sphingolipid Metabolism

(2010) Florence Bourquin et al.   STRUCTURE

pH Dependence of Sphingosine Aggregation

(2009) Hirotaka Sasaki et al.   BIOPHYSICAL JOURNAL

Sphingosine-1-Phosphate as an Amphipathic Metabolite: Its Properties in Aqueous and Membrane Environments

(2009) Marcos García-Pacios et al.   BIOPHYSICAL JOURNAL

Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation

(2009) S. Colie et al.   CANCER RESEARCH

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts

(2009) Ralf Frederik Claas et al.   CELLULAR SIGNALLING

Transport of lipids by ABC proteins: Interactions and implications for cellular toxicity, viability and function

(2009) Irving L.M.H. Aye et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Lyase to live by: Sphingosine phosphate lyase as a therapeutic target

(2009) Ashok Kumar et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids

(2009) Delphine Milhas et al.   FEBS LETTERS

Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus

(2009) A. Monier et al.   GENOME RESEARCH

Structural Insights into the Enzymatic Mechanism of Serine Palmitoyltransferase from Sphingobacterium multivorum

(2009) H. Ikushiro et al.   JOURNAL OF BIOCHEMISTRY

The External Aldimine Form of Serine Palmitoyltransferase

(2009) Marine C. C. Raman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifunctional Role of His159in the Catalytic Reaction of Serine Palmitoyltransferase

(2009) Yuka Shiraiwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders

(2009) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Common Structural Basis for pH- and Calmodulin-mediated Regulation in Plant Glutamate Decarboxylase

(2009) Heinz Gut et al.   JOURNAL OF MOLECULAR BIOLOGY

Overexpression of the Wild-Type SPT1 Subunit Lowers Desoxysphingolipid Levels and Rescues the Phenotype of HSAN1

(2009) F. S. Eichler et al.   JOURNAL OF NEUROSCIENCE

Shiga-like toxins and HIV-1 ‘go through’ glycosphingolipids and lipid rafts in renal cells

(2009) Patricio E. Ray   KIDNEY INTERNATIONAL

Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors

(2009) Florian Mullershausen et al.   Nature Chemical Biology

A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated

(2009) Thorsten Hornemann et al.   NEUROGENETICS

Plant sphingolipids: decoding the enigma of the Sphinx

(2009) Mickael O. Pata et al.   NEW PHYTOLOGIST

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

(2009) G. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The structure of Aquifex aeolicus sulfide:quinone oxidoreductase, a basis to understand sulfide detoxification and respiration

(2009) M. Marcia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

SPTLC1 Binds ABCA1 To Negatively Regulate Trafficking and Cholesterol Efflux Activity of the Transporter†

(2008) Norimasa Tamehiro et al.   BIOCHEMISTRY

Sphingosine-1-phosphate lyase in development and disease: Sphingolipid metabolism takes flight

(2008) H FYRST   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Identifying Key Residues of Sphinganine-1-phosphate Lyase for Functionin Vivoandin Vitro

(2008) Debdyuti Mukhopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic Insights into the Hydrolysis and Synthesis of Ceramide by Neutral Ceramidase

(2008) Tsuyoshi Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bioactive sphingolipids: metabolism and function

(2008) Nana Bartke et al.   JOURNAL OF LIPID RESEARCH

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli

(2008) P. Neumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

(2008) N. Kudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex

(2008) V. Brass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA