Downregulation of S1P Lyase Improves Barrier Function in Human Cerebral Microvascular Endothelial Cells Following an Inflammatory Challenge

Sphingosine-1-phosphate promotes barrier-stabilizing effects in human microvascular endothelial cells via AMPK-dependent mechanisms

(2019) Sophie Dennhardt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fifty years of lyase and a moment of truth: Sphingosine phosphate lyase from discovery to disease

(2019) Julie D. Saba   JOURNAL OF LIPID RESEARCH

Targeting the S1P receptor signaling pathways as a promising approach for treatment of autoimmune and inflammatory diseases

(2019) Bisera Stepanovska et al.   PHARMACOLOGICAL RESEARCH

Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis

(2018) Hiba Alsaffar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability

(2018) Nermin M. Kady et al.   DIABETES

Sphingolipid signaling in renal fibrosis

(2018) Andrea Huwiler et al.   MATRIX BIOLOGY

Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases

(2018) Brunilde Gril et al.   Nature Communications

Different concentrations of lipopolysaccharide regulate barrier function through the PI3K/Akt signalling pathway in human pulmonary microvascular endothelial cells

(2018) Xia Zheng et al.   Scientific Reports

Sphingosine -1 Phosphate Receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury

(2018) Nathalie Burg et al.   Arthritis & Rheumatology

Elevating Endogenous Sphingosine-1-Phosphate (S1P) Levels Improves Endothelial Function and Ameliorates Atherosclerosis in Low Density Lipoprotein Receptor-Deficient (LDL-R−/−) Mice

(2018) Renata Feuerborn et al.   THROMBOSIS AND HAEMOSTASIS

The role of dihydrosphingolipids in disease

(2018) Ruth. R. Magaye et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Size-selective opening of the blood–brain barrier by targeting endothelial sphingosine 1–phosphate receptor 1

(2017) Keisuke Yanagida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Regulation of Vascular Permeability by Vascular Endothelial Cadherin-Mediated Endothelial Cell-Cell Junctions

(2017) Seung-Sik Rho et al.   JOURNAL OF NIPPON MEDICAL SCHOOL

Regulation of pulmonary endothelial barrier function by kinases

(2016) Nektarios Barabutis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome

(2016) L. Scotti et al.   MOLECULAR HUMAN REPRODUCTION

The Regulation of NF-κB Subunits by Phosphorylation

(2016) Frank Christian et al.   Cells

Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions

(2016) Mathias J. Gerl et al.   PLoS One

miR-125b Enhances IL-8 Production in Early-Onset Severe Preeclampsia by Targeting Sphingosine-1-Phosphate Lyase 1

(2016) Weiwei Yang et al.   PLoS One

Abluminal Stimulation of Sphingosine 1-Phosphate Receptors 1 and 3 Promotes and Stabilizes Endothelial Sprout Formation

(2015) Anusuya Das et al.   TISSUE ENGINEERING PART A

Sphingosine 1-phosphate signaling at the blood–brain barrier

(2015) Briana Prager et al.   TRENDS IN MOLECULAR MEDICINE

An update on the biology of sphingosine 1-phosphate receptors

(2014) Victoria A. Blaho et al.   JOURNAL OF LIPID RESEARCH

TNF-induced endothelial barrier disruption: beyond actin and Rho

(2014) Beatriz Marcos-Ramiro et al.   THROMBOSIS AND HAEMOSTASIS

Hyperglycaemia promotes cerebral barrier dysfunction through activation of protein kinase C-β

(2013) B. Shao et al.   DIABETES OBESITY & METABOLISM

Interleukin-1β-induced barrier dysfunction is signaled through PKC-θ in human brain microvascular endothelium

(2012) Robert R. Rigor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of Sphingomyelin Synthesis in Pulmonary Endothelial Cell Cytoskeletal Activation and Endotoxin-Induced Lung Injury

(2012) Fatima Anjum et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Biphasic effect of danazol on human vascular endothelial cell permeability and f-actin cytoskeleton dynamics

(2012) Gregory W. Thomas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evidence for a link between histone deacetylation and Ca2+homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts

(2012) Katja Ihlefeld et al.   BIOCHEMICAL JOURNAL

Blood-Brain Barrier Integrity and Glial Support: Mechanisms that can be Targeted for Novel Therapeutic Approaches in Stroke

(2012) Patrick T. Ronaldson et al.   CURRENT PHARMACEUTICAL DESIGN

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

(2012) Ruben van Doorn et al.   Journal of Neuroinflammation

CCL2 disrupts the adherens junction: implications for neuroinflammation

(2012) Toni K Roberts et al.   LABORATORY INVESTIGATION

Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement

(2011) Djanybek M. Adyshev et al.   CELLULAR SIGNALLING

PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism

(2011) Florence Bourquin et al.   PROTEIN SCIENCE

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Protection of LPS-Induced Murine Acute Lung Injury by Sphingosine-1-Phosphate Lyase Suppression

(2010) Yutong Zhao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Permeability of Endothelial and Astrocyte Cocultures: In Vitro Blood–Brain Barrier Models for Drug Delivery Studies

(2010) Guanglei Li et al.   ANNALS OF BIOMEDICAL ENGINEERING

Krüppel-Like Factor-4 Transcriptionally Regulates VE-Cadherin Expression and Endothelial Barrier Function

(2010) Colleen E. Cowan et al.   CIRCULATION RESEARCH

Sphingosine 1-Phosphate Lyase Deficiency Disrupts Lipid Homeostasis in Liver

(2010) Meryem Bektas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of protein kinase Cζ in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers

(2010) Richard D. Minshall et al.   MICROVASCULAR RESEARCH

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts

(2009) Ralf Frederik Claas et al.   CELLULAR SIGNALLING

Interleukin-25 Expressed by Brain Capillary Endothelial Cells Maintains Blood-Brain Barrier Function in a Protein Kinase Cϵ-dependent Manner

(2009) Yoshifumi Sonobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Regulation of Endothelial Junctional Permeability

(2008) Emily Vandenbroucke et al.   Annals of the New York Academy of Sciences

New players on the center stage: Sphingosine 1-phosphate and its receptors as drug targets

(2008) Andrea Huwiler et al.   BIOCHEMICAL PHARMACOLOGY

The blood-brain barrier in brain homeostasis and neurological diseases

(2008) Nicolas Weiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1

(2008) X. Li et al.   BLOOD

Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier

(2008) Svetlana Stamatovic et al.   Current Neuropharmacology

Breaking the VE-cadherin bonds

(2008) Julie Gavard   FEBS LETTERS

NF-κB, but not p38 MAP Kinase, is required for TNF-α-induced expression of cell adhesion molecules in endothelial cells

(2008) Suja Rajan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of vascular permeability by sphingosine 1-phosphate

(2008) Lichun Wang et al.   MICROVASCULAR RESEARCH

Barriers in the brain: a renaissance?

(2008) Norman R. Saunders et al.   TRENDS IN NEUROSCIENCES