Article
Biochemistry & Molecular Biology
Indrani Mukherjee, Subhrajit Biswas, Sunil Singh, Joyeeta Talukdar, Mohammed S. S. Alqahtani, Mohamed Abbas, Tapas Chandra Nag, Asit Ranjan Mridha, Surabhi Gupta, Jai Bhagwan Sharma, Supriya Kumari, Ruby Dhar, Subhradip Karmakar
Summary: The overproduction of ROS has been linked to various human diseases. Monosodium glutamate (MSG), a food additive commonly used in Asian cuisine, has been associated with ROS generation. This study found that MSG exposure influenced trophoblast invasion and differentiation, two critical functions during placenta formation, through increased ROS production. The findings suggest that long-term exposure to MSG may have adverse health effects, compromising important trophoblast functions.
Article
Anatomy & Morphology
Shao-Peng Lin, Jingyi Bu, Shan Ye, Qiangda Xie, Jue-Xian Wei, Xiaofang Yin, Fen Mei, Pei-Yi Lin, Xiao-Hui Chen
Summary: This study investigated whether AMPK-induced glucose metabolic and mitochondrial dysfunction were related to glutamate-dependent ROS injury of neurons. The results showed that AMPK phosphorylation promoted glucose uptake, enhanced oxygen consumption rate and intracellular ROS levels. Inhibition of AMPK mitigated glutamate-induced cellular toxicity. These findings suggest that AMPK phosphorylation may be a potential target for treating glutamate-induced neurotoxicity.
Article
Biochemistry & Molecular Biology
Ji Yun Baek, Kiwon Jung, Young-Mi Kim, Hyun-Young Kim, Ki Sung Kang, Young-Won Chin
Summary: The study demonstrated that gamma-mangostin has a protective effect against glutamate-induced cell damage by reducing reactive oxygen species production, stimulating heme oxygenase-1 expression, and inhibiting the intrinsic mitochondrial apoptotic pathway in HT22 cells.
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Joanna Nowaczyk, Barbara Poniedzialek, Piotr Rzymski, Dominika Sikora, Mariola Ropacka-Lesiak
Summary: This study aimed to evaluate platelet parameters in pregnant women with fetal growth restriction (FGR) and their relationship with hemodynamic abnormalities. The study found that FGR patients had impaired oxidative metabolism in platelets, which may lead to oxidative stress and impaired platelet function.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Medicine, Research & Experimental
Caio Pupin Rosa, Thiago Caetano Andrade Belo, Natalia Cristina de Melo Santos, Evandro Neves Silva, Juciano Gasparotto, Patricia Paiva Corsetti, Leonardo Augusto de Almeida
Summary: Intracellular production of reactive oxygen species (ROS) plays a significant role in both the lethal effects on microorganisms and the regulation of inflammation and metabolism. Various microorganisms have been found to modulate the assembly or disruption of inflammasomes through ROS production. This process is a significant milestone in our understanding of the immunology of intracellular pathogens.
Article
Biochemistry & Molecular Biology
Anton G. Rogov, Tatiana N. Goleva, Khoren K. Epremyan, Igor I. Kireev, Renata A. Zvyagilskaya
Summary: Mitochondria are considered the primary source of ROS in cells, with ROS-induced ROS release triggered in cardiac myocytes under excessive oxidative stress. Using Dipodascus magnusii yeast cells, it was found that prooxidant-induced oxidative stress begins in mitochondria before spreading to the whole cell, with mitochondrial ROS leading to mitochondrial fragmentation.
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Mengqiu Hao, Xuyang Yang, Su Zhang, Junhong Han, Ziqiang Wang, Hai-Ning Chen
Summary: Colorectal cancer often requires adjuvant therapies to reduce tumor burden, and the efficacy of these therapies is significantly influenced by reactive oxygen species (ROS). ROS-mediated colorectal cancer adjuvant therapies involve multiple mechanisms, and preliminary clinical trials have shown the potential of ROS-manipulating therapy in enhancing treatment outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Yoon-Seok Seo, Jung-Min Park, Jae-Hyeong Kim, Moo-Yeol Lee
Summary: Smoking is a significant risk factor for various diseases due to the production of excessive reactive oxygen species (ROS). This review focuses on how cigarette smoke promotes the formation of ROS and provides key mechanisms involved.
Article
Engineering, Environmental
Steven Lelieveld, Jake Wilson, Eleni Dovrou, Ashmi Mishra, Pascale S. J. Lakey, Manabu Shiraiwa, Ulrich Poeschl, Thomas Berkemeier
Summary: Air pollutants such as aerosols and ozone can cause the generation of reactive oxygen species in the human respiratory tract, leading to oxidative stress and adverse health effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xi Huang, Wenji Lao, Youci Zhou, Yunwei Sun, Qijun Wang
Summary: The study shows that the glutamate dehydrogenase (GDH) of Salmonella plays a critical role in combating oxidative damage by promoting the generation of glutathione (GSH). GDH is particularly important for the growth of Salmonella in oxidative environments under low energy supply.
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Agriculture, Dairy & Animal Science
Mohammed A. E. Naiel, Samar S. Negm, Shakira Ghazanfar, Mustafa Shukry, Sameh A. Abdelnour
Summary: The application of high-fat diet (HFD) in fish farming can promote growth and productivity, but excessive intake leads to undesirable effects on fish performance, such as impaired growth, reduced feed efficiency, liver dysfunction, weakened immune function and decreased economic revenue. Various approaches, such as dietary manipulation and feed additives, have been used to mitigate the adverse impacts of HFD and improve fish growth and productivity.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Food Science & Technology
Kosuke Kato, Mayu Takahashi, Kentaro Oh-hashi, Kaori Ando, Yoko Hirata
Summary: Oxidative stress plays a central role in various cell death pathways, including ferroptosis. Phytochemicals, such as curcumin, quercetin, and resveratrol, protect cells against ferroptosis by reducing oxidative stress independently of the Nrf2-ARE pathway. Quercetin and resveratrol also inhibit the iron-catalyzed generation of hydroxyl radicals.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mayu Takahashi, Akie Hamamoto, Kentaro Oh-hashi, Hiroshi Takemori, Kyoji Furuta, Yoko Hirata
Summary: This study evaluated the biological activities of GIF-0726-r derivatives in iron- and oxidative stress-dependent cell death pathways. The modifications to the oxindole skeleton and other positions enhanced the antiferroptotic efficacy and reduced the accumulation of iron ions and reactive oxygen species. These findings contribute to the development of specific inhibitors for neurodegenerative diseases, cancers, and metabolic disorders.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Veterinary Sciences
Ahmed Ali Saleh, Mahmoud Mohamed Soliman, Mohammed Farid Yousef, Nabil Mohammed Eweedah, Hanan Basiouni El-Sawy, Mustafa Shukry, Mohammad A. M. Wadaan, In Ho Kim, Sungbo Cho, Hossam M. Eltahan
Summary: This study investigated the effects of supplemental herbal mixtures on milk production, quality, and blood parameters in dairy cows under high temperatures. The results showed that the herbal mixture did not affect milk production, but it reduced cholesterol levels and increased lactose content in milk.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Fisheries
Eman A. El-Sharkawy, Ibrahim M. Abd El-Razek, Asem A. Amer, Ali A. Soliman, Mustafa Shukry, Mahmoud S. Gewaily, Guillermo Tellez-Isaias, Zulhisyam Abdul Kari, Mahmoud A. O. Dawood
Summary: This study investigated the effects of sodium butyrate (SB) on Thinlip Grey Mullet. The results showed that fish-fed SB had better growth performance, digestive enzyme activity, and blood biochemistry.
AQUACULTURE REPORTS
(2023)
Article
Environmental Sciences
Tamer A. Al-Shafie, Engy A. Mahrous, Mustafa Shukry, Mohammad Y. Alshahrani, Samah F. Ibrahim, Liana Fericean, Afaf Abdelkader, Mennatallah A. Ali
Summary: Increasing cancer cell sensitivity to chemotherapy by amending aberrant metabolism using plant extracts represents a promising strategy to lower chemotherapy doses while retaining the same therapeutic outcome.
Article
Environmental Sciences
Zeinab Abdel Salam Hawash, Ensaf M. Yassien, Badriyah S. Alotaibi, Amira M. El-Moslemany, Mustafa Shukry
Summary: Jambolan fruit extract and choline were found to improve Alzheimer's disease induced by aluminum tri chloride in rats. The results showed that Jambolan fruit extract and choline can enhance brain functions, histopathology, and antioxidant enzyme activity compared with the positive control group.
Article
Fisheries
Hany M. R. Abdel-Latif, Hamada A. Ahmed, Mustafa Shukry, Asmaa F. Khafaga, Bassem Khalil Elkhayat, Mohsen Abdel-Tawwab, Rehab A. Abd-elaziz
Summary: The present study evaluated the effects of long-term salinity stress on juvenile Pangasianodon hypophthalmus and found that higher salinities led to decreased growth, feed intake, and survival rates. Additionally, stress and oxidative stress biomarkers were significantly increased in fish exposed to different salinities, with the highest levels observed in the highest salinity group. Histological changes and pathological lesions were also more pronounced in groups exposed to higher salinities. Based on the findings, it is suggested that P. hypophthalmus can tolerate salinities up to 8, with 4 being the most suitable salinity with no adverse effects on growth and minimal impact on histology and physiological responses.
Article
Fisheries
Amany M. Diab, Eslam E. Eldeghaidy, Mohamed H. Abo-Raya, Mustafa Shukry, Ahmed Abdeen, Samah F. Ibrahim, Liana Fericean, Mohamed Abdo, Malik M. Khalafalla
Summary: This research aims to investigate the effects of supplementing red tilapia's diet with ethanolic roselle calyces extract (ER) on growth, intestinal morphometry, carotene content, blood profile, immunity, and gene expression response. The results show that ER supplementation improves weight gain and feed conversion rate, enhances immune activity, and increases carotene content. Overall, dietary ER supplementation benefits red tilapia in terms of growth and immunity.
Article
Biochemistry & Molecular Biology
Basma H. Marghani, Shaymaa Rezk, Ahmed I. Ateya, Badriyah S. Alotaibi, Basma H. Othman, Samy M. Sayed, Mohammed Ali Alshehri, Mustafa Shukry, Mohamed M. Mansour
Summary: This study aimed to examine the protective and/or therapeutic effects of cerebrolysin (CBL) in managing forebrain ischemia-reperfusion (IR) injury and any probable underlying mechanisms. The results showed that CBL improved neurological functional recovery, enhanced anti-inflammatory and antioxidant activities, alleviated apoptotic neuronal death, and inhibited reactive microglial and astrocyte activation in the mouse model of forebrain IR injury. These findings suggest that CBL may improve neurologic function following IR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Heba Ghamry, Mustafa Shukry, Mohamed A. Kassab, Foad A. Farrag, Nagi M. El-Shafai, Enas Elgendy, Amany N. Ibrahim, Salwa A. Elgendy, Ali Behairy, Samah F. Ibrahim, Florin Imbrea, Florin Crista, Mohamed Abdo, Inas A. Ahmed, Marwa H. Muhammad, Hala Anwer, Ahmed Abdeen
Summary: The study found that Arthrospira platensis nanoparticles (NSP) can protect rats from aging injuries and alleviate oxidative changes caused by D-galactose (D-gal). This suggests that NSP may be a promising natural protective compound that can prevent aging.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Plant Sciences
Salwa M. Abdel Rahman, Maher A. Kamel, Mennatallah A. Ali, Badriyah S. Alotaibi, Ohud Muslat Aharthy, Mustafa Shukry, Hala Mohamed Abd El-Bary
Summary: This study compared the phytochemical composition and various biological activities of Azolla caroliniana and Azolla filiculoides. The results showed that the methanol extracts of both species exhibited antimicrobial, antioxidant, anti-inflammatory, and cytotoxicity activities, but with some differences in their chemical profiles. The methanolic extracts of A. caroliniana displayed higher cytotoxicity against HepG2 cells in a dose-dependent manner.
Article
Environmental Sciences
Walaa M. Nassar, Wafaa M. El-Kholy, Mamdouh R. El-Sawi, Nagi M. El-Shafai, Badriyah S. Alotaibi, Heba I. Ghamry, Mustafa Shukry
Summary: This study found that thymoquinone and its nanoparticles can mitigate liver damage induced by diazinon by exerting antioxidant, anti-apoptotic, and anti-inflammatory effects.
Article
Agriculture, Dairy & Animal Science
Mohammed A. E. Naiel, Abdullah I. El-Kholy, Samar S. Negm, Shakira Ghazanfar, Mustafa Shukry, Zhaowei Zhang, Ehsan Ahmadifar, Hany M. R. Abdel-Latif
Summary: The use of antibiotics in finfish and shrimp farms has been restricted and banned due to their persistence, high prices, and role in promoting antibiotic-resistant bacteria. Finding natural and environmentally safe alternatives, such as polyphenols and plant-derived phenolic compounds, is crucial for the aquaculture industry.
ANNALS OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Mohammed A. E. Naiel, Shakira Ghazanfar, Samar S. S. Negm, Mustafa Shukry, Hany M. R. Abdel-Latif
Summary: The use of antibiotics in food-producing animals and aquaculture is prohibited due to concerns about antibiotic-tolerant microorganisms, accumulation of antibiotic residues, and environmental pollution. Researchers have studied various alternatives such as probiotics, essential oils, and antimicrobial peptides (AMPs). AMPs are small peptides that can stimulate the immune system and have antimicrobial properties, making them a potential alternative to antibiotics in aquaculture.
ANNALS OF ANIMAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)