Technological advances define shifting pathway signaling from normal to primary and metastatic colorectal cancer

Longitudinal Monitoring of Intra-Tumoural Heterogeneity Using Optical Barcoding of Patient-Derived Colorectal Tumour Models

(2022) Carolyn Shembrey et al.   Cancers

Hepatocellular carcinoma organoid co-cultures mimic angiocrine crosstalk to generate inflammatory tumor microenvironment

(2022) Joanne Tze Chin Lim et al.   BIOMATERIALS

Modeling Pancreatic Cancer with Patient-Derived Organoids Integrating Cancer-Associated Fibroblasts

(2022) Yoon-Ha Go et al.   Cancers

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer

(2022) Ignasius Joanito et al.   NATURE GENETICS

Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system

(2022) Sebastian Schuth et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer‐associated fibroblasts potentiate colorectal cancer progression by crosstalk of the IGF2 – IGF1R and Hippo–YAP1 signaling pathways

(2022) Jinglin Zhang et al.   JOURNAL OF PATHOLOGY

Shifting the treatment paradigm for patients with deficient mismatch repair colon cancer: is there a role for immunotherapy?

(2021) Joseph C. Kong et al.   ANZ JOURNAL OF SURGERY

The Role of Cancer-Associated Fibroblasts in Cancer Invasion and Metastasis

(2021) Paris Jabeen Asif et al.   Cancers

The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation.

(2021) Kyle Stokes et al.   Cellular and Molecular Gastroenterology and Hepatology

Low-viscosity matrix suspension culture enables scalable analysis of patient-derived organoids and tumoroids from the large intestine

(2021) Yumiko Hirokawa et al.   Communications Biology

Organoids as a Robust Preclinical Model for Precision Medicine in Colorectal Cancer: A Systematic Review

(2021) Michael Flood et al.   ANNALS OF SURGICAL ONCOLOGY

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

(2021) Bob Chen et al.   CELL

TGF-beta signaling in cancer radiotherapy

(2021) Juan Wang et al.   CYTOKINE

Ontogeny and function of the circadian clock in intestinal organoids

(2021) Andrew E Rosselot et al.   EMBO JOURNAL

Primary and metastatic peritoneal surface malignancies

(2021) Delia Cortés-Guiral et al.   Nature Reviews Disease Primers

Comparison of the molecular and cellular phenotypes of common mouse syngeneic models with human tumors

(2020) Wenyan Zhong et al.   BMC GENOMICS

Medium-throughput drug screening of patient-derived organoids from colorectal peritoneal metastases to direct personalized therapy

(2020) Vignesh Narasimhan et al.   CLINICAL CANCER RESEARCH

AKT-dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer

(2020) Julia Varga et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

(2020) Eva Hadadi et al.   Nature Communications

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer

(2020) Y. Nancy You et al.   DISEASES OF THE COLON & RECTUM

Mutations in the notch signalling pathway are associated with enhanced anti‐tumour immunity in colorectal cancer

(2020) Fei Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Patient-Derived Xenograft vs. Organoids: A Preliminary Analysis of Cancer Research Output, Funding and Human Health Impact in 2014–2019

(2020) Lindsay J. Marshall et al.   Animals

Antagonism of IAPs enhances CAR T cell efficacy

(2019) Jessica Michie et al.   Cancer Immunology Research

Consensus molecular subgroups (CMS) of colorectal cancer (CRC) and first-line efficacy of FOLFIRI plus cetuximab or bevacizumab in the FIRE3 (AIO KRK-0306) trial

(2019) S Stintzing et al.   ANNALS OF ONCOLOGY

Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer

(2019) Steve Z. Martin et al.   BMC CANCER

A rectal cancer organoid platform to study individual responses to chemoradiation

(2019) Karuna Ganesh et al.   NATURE MEDICINE

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Tumor organoid–T-cell coculture systems

(2019) Chiara M. Cattaneo et al.   Nature Protocols

Primary tumor sidedness and benefit from FOLFOXIRI plus bevacizumab as initial therapy for metastatic colorectal cancer. Retrospective analysis of the TRIBE trial by GONO

(2018) C Cremolini et al.   ANNALS OF ONCOLOGY

Histopathological and molecular classification of colorectal cancer and corresponding peritoneal metastases

(2018) I. Ubink et al.   BRITISH JOURNAL OF SURGERY

Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models

(2018) Janneke F. Linnekamp et al.   CELL DEATH AND DIFFERENTIATION

Comparison of Western and Asian Guidelines Concerning the Management of Colon Cancer

(2018) Gianluca Pellino et al.   DISEASES OF THE COLON & RECTUM

Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis

(2018) Tamsin R M Lannagan et al.   GUT

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

(2018) Mirjana Efremova et al.   Nature Communications

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer

(2018) Luise Fuhr et al.   EBioMedicine

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

(2017) Kaja C. G. Berg et al.   Molecular Cancer

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

Defining the role of Lgr5+ stem cells in colorectal cancer: from basic research to clinical applications

(2017) Masayuki Fujii et al.   Genome Medicine

Neoadjuvant chemotherapy affects molecular classification of colorectal tumors

(2017) K Trumpi et al.   Oncogenesis

Recent developments in the treatment of metastatic colorectal cancer

(2017) Jonathan M. Loree et al.   Therapeutic Advances in Medical Oncology

Dichotomous roles of TGF-β in human cancer

(2016) Jennifer J. Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth

(2016) Yoshito Hayashi et al.   CARCINOGENESIS

A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis

(2016) Masayuki Fujii et al.   Cell Stem Cell

Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1 + Tumor-Associated Neutrophils through CCL15-CCR1 Axis

(2016) Takamasa Yamamoto et al.   CLINICAL CANCER RESEARCH

FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)

(2016) MASARU KATOH   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MUC1, MUC2, MUC5AC, and MUC6 in colorectal cancer: expression profiles and clinical significance

(2016) Johannes Betge et al.   VIRCHOWS ARCHIV

Peritoneal Tumorigenesis and Inflammation are Ameliorated by Humidified-Warm Carbon Dioxide Insufflation in the Mouse

(2015) Sandra Carpinteri et al.   ANNALS OF SURGICAL ONCOLOGY

SnapShot: Growing Organoids from Stem Cells

(2015) Toshiro Sato et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Defective Myb Function Ablates Cyclin E1 Expression and Perturbs Intestinal Carcinogenesis

(2015) D. Cheasley et al.   MOLECULAR CANCER RESEARCH

Cloning and variation of ground state intestinal stem cells

(2015) Xia Wang et al.   NATURE

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Intestinal-specific activatable Myb initiates colon tumorigenesis in mice

(2015) J Malaterre et al.   ONCOGENE

Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

(2014) John C Castle et al.   BMC GENOMICS

Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis

(2014) Markus Germann et al.   Stem Cell Research

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

(2014) Huiling Xu et al.   Cell Reports

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Myb Controls Intestinal Stem Cell Genes and Self-Renewal

(2011) Dane Cheasley et al.   STEM CELLS

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA