Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Phenotypic plasticity during metastatic colonization

(2022) Charly Jehanno et al.   TRENDS IN CELL BIOLOGY

Complex roles of nicotinamide N-methyltransferase in cancer progression

(2022) Weixuan Wang et al.   Cell Death & Disease

Overexpression of NNMT in Glioma Aggravates Tumor Cell Progression: An Emerging Therapeutic Target

(2022) Wei Sun et al.   Cancers

Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma

(2022) Anna Reustle et al.   Clinical and Translational Medicine

NNMT contributes to high metastasis of triple negative breast cancer by enhancing PP2A/MEK/ERK/c-Jun/ABCA1 pathway mediated membrane fluidity

(2022) Yanzhong Wang et al.   CANCER LETTERS

Nicotinamide N-methyltransferase: At the crossroads between cellular metabolism and epigenetic regulation

(2021) Annalisa Roberti et al.   Molecular Metabolism

Cancer cell metabolism connects epigenetic modifications to transcriptional regulation

(2021) Ashby J. Morrison   FEBS Journal

Hepatic stellate cells suppress NK cell-sustained breast cancer dormancy

(2021) Ana Luísa Correia et al.   NATURE

A glitch in the matrix: organ-specific matrisomes in metastatic niches

(2021) Sarah K. Deasy et al.   TRENDS IN CELL BIOLOGY

Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

(2020) Chenxi Tian et al.   CANCER RESEARCH

High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer

(2020) Mengmeng Song et al.   Cancer Medicine

Cryptic collagen elements as signaling hubs in the regulation of tumor growth and metastasis

(2020) XiangHua Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The evolving metabolic landscape of chromatin biology and epigenetics

(2020) Ziwei Dai et al.   NATURE REVIEWS GENETICS

Fibronectin-Expressing Mesenchymal Tumor Cells Promote Breast Cancer Metastasis

(2020) Brian H. Jun et al.   Cancers

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

(2020) Gianmarco Rinaldi et al.   MOLECULAR CELL

Clinical significance and biological role of cancer-derived Type I collagen in lung and esophageal cancers

(2019) Shuo Fang et al.   Thoracic Cancer

Glucocorticoids promote breast cancer metastasis

(2019) Milan M. S. Obradović et al.   NATURE

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

(2019) Ilaria Elia et al.   NATURE

Role of H3K9me3 heterochromatin in cell identity establishment and maintenance

(2019) Dario Nicetto et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

(2019) Mark A. Eckert et al.   NATURE

Next-generation characterization of the Cancer Cell Line Encyclopedia

(2019) Mahmoud Ghandi et al.   NATURE

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(2019) Uku Raudvere et al.   NUCLEIC ACIDS RESEARCH

The NCATS BioPlanet – An Integrated Platform for Exploring the Universe of Cellular Signaling Pathways for Toxicology, Systems Biology, and Chemical Genomics

(2019) Ruili Huang et al.   Frontiers in Pharmacology

Elevated N‐methyltransferase expression induced by hepatic stellate cells contributes to the metastasis of hepatocellular carcinoma via regulation of the CD44v3 isoform

(2019) Jie Li et al.   Molecular Oncology

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Metabolic Hallmarks of Metastasis Formation

(2018) Ilaria Elia et al.   TRENDS IN CELL BIOLOGY

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets

(2018) Vera Miranda-Gonçalves et al.   Frontiers in Genetics

The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα

(2017) Adrian Britschgi et al.   NATURE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme

(2017) Pavlos Pissios   TRENDS IN ENDOCRINOLOGY AND METABOLISM

EMT, cell plasticity and metastasis

(2016) Christine L. Chaffer et al.   CANCER AND METASTASIS REVIEWS

Evaluation and Improvement of Quantification Accuracy in Isobaric Mass Tag-Based Protein Quantification Experiments

(2016) Erik Ahrné et al.   JOURNAL OF PROTEOME RESEARCH

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

Erratum: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity

(2015) Davide Sartini et al.   BIOLOGICAL CHEMISTRY

Methylation and expression of the tumour suppressor, PRDM5, in colorectal cancer and polyp subgroups

(2015) Catherine E Bond et al.   BMC CANCER

Differential expression of epithelial–mesenchymal transition and stem cell markers in intrinsic subtypes of breast cancer

(2015) Victoria Pomp et al.   BREAST CANCER RESEARCH AND TREATMENT

The Molecular Taxonomy of Primary Prostate Cancer

(2015) Adam Abeshouse et al.   CELL

Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development

(2015) Qian Wang et al.   JOURNAL OF PATHOLOGY

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

(2015) Silvana Konermann et al.   NATURE

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

(2015) Henrik Sperber et al.   NATURE CELL BIOLOGY

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

(2015) Shangyu Hong et al.   NATURE MEDICINE

DNA methylation pathways and their crosstalk with histone methylation

(2015) Jiamu Du et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concomitant Detection of HER2 Protein and Gene Alterations by Immunohistochemistry (IHC) and Silver Enhanced In Situ Hybridization (SISH) Identifies HER2 Positive Breast Cancer with and without Gene Amplification

(2014) Zsuzsanna Varga et al.   PLoS One

Metabolic Mechanisms of Epigenetic Regulation

(2013) Jordan L. Meier   ACS Chemical Biology

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

(2013) Olesya A Ulanovskaya et al.   Nature Chemical Biology

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

(2012) Davis J. McCarthy et al.   NUCLEIC ACIDS RESEARCH

Molecular Characteristics and Metastasis Predictor Genes of Triple-Negative Breast Cancer: A Clinical Study of Triple-Negative Breast Carcinomas

(2012) Wen-Hung Kuo et al.   PLoS One

Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

(2012) Giorgio Giacomo Galli et al.   PLoS Genetics

Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo

(2011) Dimitris Anastassiou et al.   BMC CANCER

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Genes and Gene Ontologies Common to Airflow Obstruction and Emphysema in the Lungs of Patients with COPD

(2011) Santiyagu M. Savarimuthu Francis et al.   PLoS One

The Epigenetic Modifier PRDM5 Functions as a Tumor Suppressor through Modulating WNT/β-Catenin Signaling and Is Frequently Silenced in Multiple Tumors

(2011) Xing-sheng Shu et al.   PLoS One

Expression and Functional Significance of Nicotinamide N-methyl Transferase in Skeletal Muscles of Patients with Chronic Obstructive Pulmonary Disease

(2010) Ho Cheol Kim et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ultrahigh Performance Liquid Chromatography−Tandem Mass Spectrometry Method for Fast and Robust Quantification of Anionic and Aromatic Metabolites

(2010) Joerg Martin Buescher et al.   ANALYTICAL CHEMISTRY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

(2010) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

(2009) Balazs Györffy et al.   BREAST CANCER RESEARCH AND TREATMENT

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Expression of nicotinamide N-methyltransferase in hepatocellular carcinoma is associated with poor prognosis

(2009) Jongmin Kim et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype

(2008) D. Sarrio et al.   CANCER RESEARCH

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration

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