A glitch in the matrix: organ-specific matrisomes in metastatic niches

Modification of the extracellular matrix (ECM) is a critical aspect of developing a metastasis-supportive organ niche. Recent work investigating ECM changes that facilitate metastasis has revealed ways in which different metastatic organ niches are similar as well as the distinct characteristics that make them unique. In this review, we present recent findings regarding how ECM modifications support metastasis in four frequent metastatic sites: the lung, liver, bone, and brain. We discuss ways in which these modifications are shared between metastatic organs as well as features specific to each location. We also discuss areas of technical innovation that could be advantageous to future research and areas of inquiry that merit further investigation.

Automated summary

This review presents recent findings on how modifications of the extracellular matrix (ECM) support metastasis in common metastatic sites such as the lung, liver, bone, and brain. Shared ECM modifications as well as site-specific characteristics are discussed. Areas of technical innovation and further research are also explored.