Advances in Clinical Mass Cytometry

Robust single-cell matching and multimodal analysis using shared and distinct features

(2023) Bokai Zhu et al.   NATURE METHODS

Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

(2022) J. Joseph Melenhorst et al.   NATURE

Twin study reveals non-heritable immune perturbations in multiple sclerosis

(2022) Florian Ingelfinger et al.   NATURE

Mass cytometry reveals a conserved immune trajectory of recovery in hospitalized COVID-19 patients

(2022) Cassandra E. Burnett et al.   IMMUNITY

Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine

(2022) Kevin J. Kramer et al.   Nature Communications

Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

(2022) Zinaida Good et al.   NATURE MEDICINE

The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support

(2021) Anja Irmisch et al.   CANCER CELL

Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response

(2021) Lauren S. Levine et al.   IMMUNITY

Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity

(2021) Sanne E. de Jong et al.   NATURE IMMUNOLOGY

Immune Profiling Mass Cytometry Assay Harmonization: Multicenter Experience from CIMAC-CIDC

(2021) Bita Sahaf et al.   CLINICAL CANCER RESEARCH

Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study

(2021) et al.   Science Immunology

OMIP‐080: 29‐Color flow cytometry panel for comprehensive evaluation of NK and T cells reconstitution after hematopoietic stem cells transplantation

(2021) Sarka Vanikova et al.   CYTOMETRY PART A

mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

(2021) Jason Neidleman et al.   eLife

Cell-type-specific signaling networks in heterocellular organoids

(2020) Xiao Qin et al.   NATURE METHODS

Helminth infections drive heterogeneity in human type 2 and regulatory cells

(2020) Karin de Ruiter et al.   Science Translational Medicine

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

High-dimensional immune profiling by mass cytometry revealed immunosuppression and dysfunction of immunity in COVID-19 patients

(2020) Wenjing Wang et al.   Cellular & Molecular Immunology

Effects of Hepatitis B Surface Antigen on Virus-specific and Global T Cells in Patients With Chronic HBV infection

(2020) Nina Le Bert et al.   GASTROENTEROLOGY

Comprehensive Immunoprofiling of Pediatric Zika Reveals Key Role for Monocytes in the Acute Phase and No Effect of Prior Dengue Virus Infection

(2020) Daniela Michlmayr et al.   Cell Reports

Immunologic timeline of Ebola virus disease and recovery in humans

(2020) Anita K. McElroy et al.   JCI Insight

OMIP‐069 : Forty‐Color Full Spectrum Flow Cytometry Panel for Deep Immunophenotyping of Major Cell Subsets in Human Peripheral Blood

(2020) Lily M. Park et al.   CYTOMETRY PART A

Single-cell sequencing techniques from individual to multiomics analyses

(2020) Yukie Kashima et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Single-cell metabolic profiling of human cytotoxic T cells

(2020) Felix J. Hartmann et al.   NATURE BIOTECHNOLOGY

Development of a 43 color panel for the characterization of conventional and unconventional T‐cell subsets, B cells, NK cells, monocytes, dendritic cells, and innate lymphoid cells using spectral flow cytometry

(2020) Fairooz Sahir et al.   CYTOMETRY PART A

Ab initio spillover compensation in mass cytometry data

(2020) Qi Miao et al.   CYTOMETRY PART A

Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

(2019) Asbjørn Christophersen et al.   NATURE MEDICINE

Dengue-specific CD8+ T cell subsets display specialized transcriptomic and TCR profiles

(2019) Yuan Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling

(2019) Xiao-Kang Lun et al.   MOLECULAR CELL

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry

(2019) Jolanda Brummelman et al.   Nature Protocols

Mass cytometry reveals systemic and local immune signatures that distinguish inflammatory bowel diseases

(2019) Samuel J. S. Rubin et al.   Nature Communications

Cytometry by time of flight identifies distinct signatures in patients with systemic sclerosis, systemic lupus erythematosus and Sjögrens syndrome

(2019) Maarten van der Kroef et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates

(2019) Melissa Hui Yen Chng et al.   IMMUNITY

Multi-parameter immune profiling of peripheral blood mononuclear cells by multiplexed single-cell mass cytometry in patients with early multiple sclerosis

(2019) Chotima Böttcher et al.   Scientific Reports

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Single-cell epigenetics – Chromatin modification atlas unveiled by mass cytometry

(2018) Peggie Cheung et al.   CLINICAL IMMUNOLOGY

OMIP-044: 28-color immunophenotyping of the human dendritic cell compartment

(2018) Florian Mair et al.   CYTOMETRY PART A

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Comparison of CyTOF assays across sites: Results of a six-center pilot study

(2018) Michael D. Leipold et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse

(2018) Zinaida Good et al.   NATURE MEDICINE

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Chimeric Antigen Receptor Therapy

(2018) Carl H. June et al.   NEW ENGLAND JOURNAL OF MEDICINE

Commonly Occurring Cell Subsets in High-Grade Serous Ovarian Tumors Identified by Single-Cell Mass Cytometry

(2018) Veronica D. Gonzalez et al.   Cell Reports

Compensation of Signal Spillover in Suspension and Imaging Mass Cytometry

(2018) Stéphane Chevrier et al.   Cell Systems

IL-15 regulates susceptibility of CD4+ T cells to HIV infection

(2018) Lara Manganaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis

(2018) Chamith Y. Fonseka et al.   Science Translational Medicine

Biochemical Underpinnings of Immune Cell Metabolic Phenotypes

(2017) Benjamin A. Olenchock et al.   IMMUNITY

Mass cytometry identifies a distinct monocyte cytokine signature shared by clinically heterogeneous pediatric SLE patients

(2017) W.E. O'Gorman et al.   JOURNAL OF AUTOIMMUNITY

Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy

(2017) Jana Blazkova et al.   JOURNAL OF IMMUNOLOGY

Identity and Diversity of Human Peripheral Th and T Regulatory Cells Defined by Single-Cell Mass Cytometry

(2017) Matthew A. Kunicki et al.   JOURNAL OF IMMUNOLOGY

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

(2017) Deepak A. Rao et al.   NATURE

Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry

(2017) Xiao-Kang Lun et al.   NATURE BIOTECHNOLOGY

High-dimensional, single-cell characterization of the brain's immune compartment

(2017) Ben Korin et al.   NATURE NEUROSCIENCE

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis

(2017) M. H. Al-Mossawi et al.   Nature Communications

Visual analysis of mass cytometry data by hierarchical stochastic neighbour embedding reveals rare cell types

(2017) Vincent van Unen et al.   Nature Communications

Mass Cytometric Analysis of HIV Entry, Replication, and Remodeling in Tissue CD4+ T Cells

(2017) Marielle Cavrois et al.   Cell Reports

Mass Cytometry: Single Cells, Many Features

(2016) Matthew H. Spitzer et al.   CELL

Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets

(2016) Vincent van Unen et al.   IMMUNITY

Highly multiplexed simultaneous detection of RNAs and proteins in single cells

(2016) Andreas P Frei et al.   NATURE METHODS

Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium

(2016) Greg Finak et al.   Scientific Reports

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

Impact of peripheral myeloid cells on amyloid-β pathology in Alzheimer’s disease–like mice

(2015) Stefan Prokop et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Conditional density-based analysis of T cell signaling in single-cell data

(2014) S. Krishnaswamy et al.   SCIENCE

viSNE enables visualization of high dimensional single-cell data and reveals phenotypic heterogeneity of leukemia

(2013) El-ad David Amir et al.   NATURE BIOTECHNOLOGY

How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy

(2013) Georg Schett et al.   NATURE MEDICINE

Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators

(2012) Bernd Bodenmiller et al.   NATURE BIOTECHNOLOGY

A deep profiler's guide to cytometry

(2012) Sean C. Bendall et al.   TRENDS IN IMMUNOLOGY

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

Molecular mechanisms in signal transduction at the membrane

(2010) Jay T Groves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay Based on Inductively Coupled Plasma Time-of-Flight Mass Spectrometry

(2009) Dmitry R. Bandura et al.   ANALYTICAL CHEMISTRY

Modeling multiple sclerosis in laboratory animals

(2009) Bettina Schreiner et al.   Seminars in Immunopathology

Concurrent detection of secreted products from human lymphocytes by microengraving: Cytokines and antigen-reactive antibodies

(2008) Elizabeth M. Bradshaw et al.   CLINICAL IMMUNOLOGY