A neutrophil response linked to tumor control in immunotherapy

Neutrophil phenotypes and functions in cancer: A consensus statement

(2022) Daniela F. Quail et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Different syngeneic tumors show distinctive intrinsic tumor-immunity and mechanisms of actions (MOA) of anti-PD-1 treatment

(2022) Ying Jin et al.   Scientific Reports

Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening

(2022) Marianna Ioannou et al.   Nature Communications

Tumor and immune reprogramming during immunotherapy in advanced renal cell carcinoma

(2021) Kevin Bi et al.   CANCER CELL

Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

(2021) Chang Cui et al.   CELL

A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer

(2021) Ayse Bassez et al.   NATURE MEDICINE

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments

(2021) Ricardo Grieshaber-Bouyer et al.   Nature Communications

Consolidation nivolumab and ipilimumab versus observation in limited-disease small cell lung cancer after chemo-radiotherapy – Results from the randomised phase II ETOP/IFCT 4-12 STIMULI trial

(2021) S. Peters et al.   ANNALS OF ONCOLOGY

CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

(2021) Mauro Di Pilato et al.   CELL

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

(2021) Amaia Martinez-Usatorre et al.   Science Translational Medicine

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity

(2021) Vijayashree Mysore et al.   Nature Communications

A sustained type I IFN-neutrophil-IL-18 axis drives pathology during mucosal viral infection

(2021) Tania Lebratti et al.   eLife

NF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity

(2021) Ghita Ghislat et al.   Science Immunology

Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy

(2021) Marie Siwicki et al.   Science Immunology

Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity

(2021) Ellen Duong et al.   IMMUNITY

Versatile neutrophil functions in cancer

(2021) Marie Siwicki et al.   SEMINARS IN IMMUNOLOGY

Dimensions of neutrophil life and fate

(2021) Andrés Hidalgo et al.   SEMINARS IN IMMUNOLOGY

Lack of CD8 + T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer

(2021) Brendan L. Horton et al.   Science Immunology

Circulating neutrophil subsets in advanced lung cancer patients exhibit unique immune signature and relate to prognosis

(2020) Merav E. Shaul et al.   FASEB JOURNAL

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

Durable and controlled depletion of neutrophils in mice

(2020) Gael Boivin et al.   Nature Communications

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor

(2020) Immanuel Kwok et al.   IMMUNITY

DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25

(2020) Linbin Yang et al.   NATURE

Generalizing RNA velocity to transient cell states through dynamical modeling

(2020) Volker Bergen et al.   NATURE BIOTECHNOLOGY

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

(2020) Xuemei Xie et al.   NATURE IMMUNOLOGY

Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction

(2020) Ehsan Vafadarnejad et al.   CIRCULATION RESEARCH

Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow

(2020) Huy Q. Dinh et al.   IMMUNITY

Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils

(2020) Christina Pfirschke et al.   Cell Reports

CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage

(2020) Yanfang Peipei Zhu et al.   Journal for ImmunoTherapy of Cancer

Tumor-infiltrating dendritic cell states are conserved across solid human cancers

(2020) Genevieve M. Gerhard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils escort circulating tumour cells to enable cell cycle progression

(2019) Barbara Maria Szczerba et al.   NATURE

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

ChEA3: transcription factor enrichment analysis by orthogonal omics integration

(2019) Alexandra B Keenan et al.   NUCLEIC ACIDS RESEARCH

The Neutrophil Life Cycle

(2019) Andrés Hidalgo et al.   TRENDS IN IMMUNOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

(2019) Andrea Ponzetta et al.   CELL

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

Tumour-associated neutrophils in patients with cancer

(2019) Merav E. Shaul et al.   Nature Reviews Clinical Oncology

Neutrophil Cathepsin G and Tumor Cell RAGE Facilitate Neutrophil Anti-Tumor Cytotoxicity

(2019) Ronit Vogt Sionov et al.   OncoImmunology

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms

(2019) Ik Sun Kim et al.   NATURE CELL BIOLOGY

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells

(2018) Maya Gershkovitz et al.   CANCER RESEARCH

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

Neutrophils Kill Antibody-Opsonized Cancer Cells by Trogoptosis

(2018) Hanke L. Matlung et al.   Cell Reports

Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumab

(2018) Mariaelena Capone et al.   Journal for ImmunoTherapy of Cancer

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

(2018) Matthew M. Gubin et al.   CELL

The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment

(2018) Gurkan Mollaoglu et al.   IMMUNITY

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

The Neutrophil Nucleus: An Important Influence on Neutrophil Migration and Function

(2018) Harriet R. Manley et al.   Frontiers in Immunology

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhighneutrophils

(2017) Camilla Engblom et al.   SCIENCE

Neutrophils dominate the immune cell composition in non-small cell lung cancer

(2017) Julia Kargl et al.   Nature Communications

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Origin and Role of a Subset of Tumor-Associated Neutrophils with Antigen-Presenting Cell Features in Early-Stage Human Lung Cancer

(2016) Sunil Singhal et al.   CANCER CELL

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

Single-cell barcoding and sequencing using droplet microfluidics

(2016) Rapolas Zilionis et al.   Nature Protocols

CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer

(2016) Katelyn T. Byrne et al.   Cell Reports

Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells

(2016) B. Homet Moreno et al.   Cancer Immunology Research

Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs

(2016) Merav E. Shaul et al.   OncoImmunology

Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells

(2015) Adam Blaisdell et al.   CANCER CELL

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Type I Interferon Transcriptional Signature in Neutrophils and Low-Density Granulocytes Are Associated with Tissue Damage in Malaria

(2015) Bruno Coelho Rocha et al.   Cell Reports

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer

(2014) Evgeniy B. Eruslanov et al.   JOURNAL OF CLINICAL INVESTIGATION

Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis

(2014) Arnoud J. Templeton et al.   JNCI-Journal of the National Cancer Institute

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

(2013) Y Ino et al.   BRITISH JOURNAL OF CANCER

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase

(2009) Michel DuPage et al.   Nature Protocols

Large-scale assignment of orthology: back to phylogenetics?

(2008) Toni Gabaldón   GENOME BIOLOGY