Tumor-infiltrating dendritic cell states are conserved across solid human cancers

Melanoma-secreted lysosomes trigger monocyte-derived dendritic cell apoptosis and limit cancer immunotherapy

(2020) Nadine Santana-Magal et al.   CANCER RESEARCH

Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer

(2020) Anthony R. Cillo et al.   IMMUNITY

The single-cell pathology landscape of breast cancer

(2020) Hartland W. Jackson et al.   NATURE

Single-cell genomic approaches for developing the next generation of immunotherapies

(2020) Ido Yofe et al.   NATURE MEDICINE

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Lineage tracing on transcriptional landscapes links state to fate during differentiation

(2020) Caleb Weinreb et al.   SCIENCE

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

(2020) Samarth Hegde et al.   CANCER CELL

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

(2020) Lei Zhang et al.   CELL

Tools and Concepts for Interrogating and Defining Cellular Identity

(2020) Kara L. McKinley et al.   Cell Stem Cell

ACKR4 restrains antitumor immunity by regulating CCL21

(2020) Carly E. Whyte et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Dissecting cellular crosstalk by sequencing physically interacting cells

(2020) Amir Giladi et al.   NATURE BIOTECHNOLOGY

Lineage tracing meets single-cell omics: opportunities and challenges

(2020) Daniel E. Wagner et al.   NATURE REVIEWS GENETICS

Sufficiency of CD40 activation and immune checkpoint blockade for T cell priming and tumor immunity

(2020) Alexander H. Morrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

(2020) Nayoung Kim et al.   Nature Communications

IFN-III is selectively produced by cDC1 and predicts good clinical outcome in breast cancer

(2020) Margaux Hubert et al.   Science Immunology

Visualizing Synaptic Transfer of Tumor Antigens among Dendritic Cells

(2020) Megan K. Ruhland et al.   CANCER CELL

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma

(2020) Andrew L. Ji et al.   CELL

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

(2020) Junbin Qian et al.   CELL RESEARCH

Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

(2020) Pierre Bourdely et al.   IMMUNITY

Type 1 conventional dendritic cells are systemically dysregulated early in pancreatic carcinogenesis

(2020) Jeffrey H. Lin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

(2019) Mikhail Binnewies et al.   CELL

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

A comparison of single-cell trajectory inference methods

(2019) Wouter Saelens et al.   NATURE BIOTECHNOLOGY

Benchmark and integration of resources for the estimation of human transcription factor activities

(2019) Luz Garcia-Alonso et al.   GENOME RESEARCH

Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

(2019) Jerome C. Martin et al.   CELL

Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche

(2019) Johnny Bonnardel et al.   IMMUNITY

Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

(2019) Charles-Antoine Dutertre et al.   IMMUNITY

High-definition spatial transcriptomics for in situ tissue profiling

(2019) Sanja Vickovic et al.   NATURE METHODS

Next-generation computational tools for interrogating cancer immunity

(2019) Francesca Finotello et al.   NATURE REVIEWS GENETICS

Cell Type Purification by Single-Cell Transcriptome-Trained Sorting

(2019) Chloé S. Baron et al.   CELL

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

(2019) Chrysothemis C. Brown et al.   CELL

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

NicheNet: modeling intercellular communication by linking ligands to target genes

(2019) Robin Browaeys et al.   NATURE METHODS

Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy

(2019) John-Michael Williford et al.   Science Advances

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

CCL19-producing fibroblastic stromal cells restrain lung carcinoma growth by promoting local antitumor T-cell responses

(2018) Hung-Wei Cheng et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

β-Catenin–mediated immune evasion pathway frequently operates in primary cutaneous melanomas

(2018) Jérémie Nsengimana et al.   JOURNAL OF CLINICAL INVESTIGATION

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

Mapping the physical network of cellular interactions

(2018) Jean-Charles Boisset et al.   NATURE METHODS

Perturbation-response genes reveal signaling footprints in cancer gene expression

(2018) Michael Schubert et al.   Nature Communications

Highly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes

(2018) Jia-Ren Lin et al.   eLife

A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility

(2018) Darren A. Cusanovich et al.   CELL

RNA velocity of single cells

(2018) Gioele La Manno et al.   NATURE

Multiplexed protein maps link subcellular organization to cellular states

(2018) Gabriele Gut et al.   SCIENCE

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

WDFY4 is required for cross-presentation in response to viral and tumor antigens

(2018) Derek J. Theisen et al.   SCIENCE

Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes

(2017) Alberto Yáñez et al.   IMMUNITY

High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization

(2017) Marcela Alcántara-Hernández et al.   IMMUNITY

Development of conventional dendritic cells: from common bone marrow progenitors to multiple subsets in peripheral tissues

(2017) D Sichien et al.   Mucosal Immunology

Simultaneous epitope and transcriptome measurement in single cells

(2017) Marlon Stoeckius et al.   NATURE METHODS

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

(2017) Filippo Veglia et al.   Nature Communications

Interleukin-12 from CD103 + Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis

(2017) Deepak Mittal et al.   Cancer Immunology Research

Transcriptional Control of Dendritic Cell Development

(2016) Theresa L. Murphy et al.   Annual Review of Immunology

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Mass Cytometry: Single Cells, Many Features

(2016) Matthew H. Spitzer et al.   CELL

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

Broad and Largely Concordant Molecular Changes Characterize Tolerogenic and Immunogenic Dendritic Cell Maturation in Thymus and Periphery

(2016) Laurence Ardouin et al.   IMMUNITY

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses

(2016) Kelly D Moynihan et al.   NATURE MEDICINE

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

(2016) Damya Laoui et al.   Nature Communications

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Homeostatic NF-κB Signaling in Steady-State Migratory Dendritic Cells Regulates Immune Homeostasis and Tolerance

(2015) Myriam Baratin et al.   IMMUNITY

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dendritic cells require NIK for CD40-dependent cross-priming of CD8+T cells

(2015) Anand K. Katakam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatially resolved, highly multiplexed RNA profiling in single cells

(2015) K. H. Chen et al.   SCIENCE

Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells

(2015) A. R. Sanchez-Paulete et al.   Cancer Discovery

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

Dendritic cell maturation: functional specialization through signaling specificity and transcriptional programming

(2014) M. Dalod et al.   EMBO JOURNAL

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine

(2014) Niroshana Anandasabapathy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CpG ODN Nanorings Induce IFN  from Plasmacytoid Dendritic Cells and Demonstrate Potent Vaccine Adjuvant Activity

(2014) B. Gungor et al.   Science Translational Medicine

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Tumor Promotion by Intratumoral Plasmacytoid Dendritic Cells Is Reversed by TLR7 Ligand Treatment

(2013) I. Le Mercier et al.   CANCER RESEARCH

CCL2/CCR2-Dependent Recruitment of Functional Antigen-Presenting Cells into Tumors upon Chemotherapy

(2013) Yuting Ma et al.   CANCER RESEARCH

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells

(2013) Vanja Sisirak et al.   INTERNATIONAL JOURNAL OF CANCER

Plasmacytoid Dendritic Cells Support Melanoma Progression by Promoting Th2 and Regulatory Immunity through OX40L and ICOSL

(2013) C. Aspord et al.   Cancer Immunology Research

Decisions About Dendritic Cells: Past, Present, and Future

(2012) Ralph M. Steinman   Annual Review of Immunology

Impaired IFN-  Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

(2012) V. Sisirak et al.   CANCER RESEARCH

Deciphering the transcriptional network of the dendritic cell lineage

(2012) Jennifer C Miller et al.   NATURE IMMUNOLOGY

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmacytoid dendritic cells infiltrating ovarian cancer are associated with poor prognosis

(2012) Sana Intidhar Labidi-Galy et al.   OncoImmunology

Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer

(2011) S. I. Labidi-Galy et al.   CANCER RESEARCH

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross-priming and tumor regression in mice

(2008) Chengwen Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE