Chemotherapeutic drugs-induced pyroptosis mediated by gasdermin E promotes the progression and chemoresistance of pancreatic cancer

Targeting Interleukin-6/Glycoprotein-130 Signaling by Raloxifene or SC144 Enhances Paclitaxel Efficacy in Pancreatic Cancer

(2023) Nina A. Hering et al.   Cancers

Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

(2022) Jiadi Lv et al.   NATURE CELL BIOLOGY

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

(2021) Xiujin Shen et al.   Cell Death & Disease

Treatment landscape of metastatic pancreatic cancer

(2021) Sara De Dosso et al.   CANCER TREATMENT REVIEWS

The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8

(2021) Jia-yuan Zhang et al.   CELL RESEARCH

Prognostic role of DFNA5 in head and neck squamous cell carcinoma revealed by systematic expression analysis

(2021) Zhiguo Liu et al.   BMC CANCER

Caspase‐3‐mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway

(2021) Ziwen Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pyroptosis at the forefront of anticancer immunity

(2021) Reid Loveless et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

(2021) Zilin Li et al.   NATURE

Microenvironment‐Responsive Prodrug‐Induced Pyroptosis Boosts Cancer Immunotherapy

(2021) Yao Xiao et al.   Advanced Science

Caveolin-2 is regulated by BRD4 and contributes to cell growth in pancreatic cancer

(2020) Feng Jiao et al.   Cancer Cell International

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate

(2020) Lei Hu et al.   Cell Death & Disease

Pancreatic cancer

(2020) Jonathan D Mizrahi et al.   LANCET

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma

(2019) Mengjiao Wu et al.   EBioMedicine

Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon cancer cells

(2019) Junhui Yu et al.   Cell Death & Disease

Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation

(2019) Cheng-cheng Zhang et al.   APOPTOSIS

Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro

(2019) Pian Yu et al.   ACTA PHARMACOLOGICA SINICA

Dihydroartemisinin represses esophageal cancer glycolysis by down-regulating pyruvate kinase M2

(2019) Shumin Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome

(2019) Lingbin Sun et al.   Cell Death & Disease

The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma

(2019) Yang Kong et al.   Frontiers in Oncology

Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway

(2019) Yiwei Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Epigenetics-Based Tumor Cells Pyroptosis for Enhancing the Immunological Effect of Chemotherapeutic Nanocarriers

(2019) Jin-Xuan Fan et al.   NANO LETTERS

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

(2019) Melanie Fritsch et al.   NATURE

Irinotecan: 25 years of cancer treatment

(2019) Christian Bailly   PHARMACOLOGICAL RESEARCH

GSDME mediates caspase-3-dependent pyroptosis in gastric cancer

(2018) Yubin Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer

(2018) Lieselot Croes et al.   Clinical Epigenetics

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis

(2018) Meihong Deng et al.   IMMUNITY

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death

(2017) Corey Rogers et al.   Nature Communications

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

The expression and regulation of DFNA5 in human hepatocellular carcinoma DFNA5 in hepatocellular carcinoma

(2013) Cong-Jun Wang et al.   MOLECULAR BIOLOGY REPORTS

Aberrant promoter methylation and tumor suppressive activity of the DFNA5 gene in colorectal carcinoma

(2008) M S Kim et al.   ONCOGENE