Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis

Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages

(2023) Mélanie Tichet et al.   IMMUNITY

OmicsNet 2.0: a web-based platform for multi-omics integration and network visual analytics

(2022) Guangyan Zhou et al.   NUCLEIC ACIDS RESEARCH

Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities

(2022) Tae Kon Kim et al.   NATURE REVIEWS DRUG DISCOVERY

Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape

(2022) Timofey A. Karginov et al.   Nature Communications

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells

(2022) Laura Codarri Deak et al.   NATURE

Lactate increases stemness of CD8 + T cells to augment anti-tumor immunity

(2022) Qiang Feng et al.   Nature Communications

Induction of ADAM10 by RT drives fibrosis, resistance, and EMT in pancreatic cancer

(2021) Adam C. Mueller et al.   CANCER RESEARCH

MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights

(2021) Zhiqiang Pang et al.   NUCLEIC ACIDS RESEARCH

A reservoir of stem-like CD8 + T cells in the tumor-draining lymph node preserves the ongoing anti-tumor immune response

(2021) Kelli A. Connolly et al.   Science Immunology

Targeting Treg-Expressed STAT3 Enhances NK-Mediated Surveillance of Metastasis and Improves Therapeutic Response in Pancreatic Adenocarcinoma

(2021) Miles Piper et al.   CLINICAL CANCER RESEARCH

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

(2021) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

NK cells for cancer immunotherapy

(2020) Noriko Shimasaki et al.   NATURE REVIEWS DRUG DISCOVERY

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity

(2020) Dalton Hermans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

(2020) Samarth Hegde et al.   CANCER CELL

Regulatory t cell metabolism at the intersection between autoimmune diseases and cancer

(2020) Henry Kurniawan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

(2020) Devin M. Jones et al.   JOURNAL OF IMMUNOLOGY

Extraction-free whole transcriptome gene expression analysis of FFPE sections and histology-directed subareas of tissue

(2019) Christy L. Trejo et al.   PLoS One

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Cells and Cancer: From Biology to Therapeutic Intervention

(2019) Wylie et al.   Cancers

The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location

(2019) Daniel A. Walsh et al.   JOURNAL OF IMMUNOLOGY

Dendritic cells in pancreatic cancer immunotherapy: Vaccines and combination immunotherapies

(2019) Jia Yang et al.   PATHOLOGY RESEARCH AND PRACTICE

Interleukin-7 enhances anti-tumor activity of CD8 + T cells in patients with hepatocellular carcinoma

(2018) Dengke Teng et al.   CYTOKINE

Fatty acid metabolism in CD8+ T cell memory: Challenging current concepts

(2018) Brenda Raud et al.   IMMUNOLOGICAL REVIEWS

IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor

(2018) Keishi Adachi et al.   NATURE BIOTECHNOLOGY

The Role of Lipid Metabolism in T Lymphocyte Differentiation and Survival

(2018) Duncan Howie et al.   Frontiers in Immunology

A Role for Tryptophan-2,3-dioxygenase in CD8 T Cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma

(2018) Lisa I Greene et al.   MOLECULAR CANCER RESEARCH

Pancreatic cancer: challenges and opportunities

(2018) Huiyun Zhu et al.   BMC Medicine

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs

(2018) Martin Y. Fan et al.   Cell Reports

Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive and Immunosuppressive Cells in the Anti-tumor Efficacy

(2018) Lorenzo Mortara et al.   Frontiers in Immunology

Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act

(2018) Vandana Kalia et al.   Frontiers in Immunology

A systematic assessment of statistics, risk factors, and underlying features involved in pancreatic cancer

(2018) Imlimaong Aier et al.   Cancer Epidemiology

Fine-Tuning of CD8 + T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

(2016) Devin P. Champagne et al.   IMMUNITY

S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate

(2016) Petros A. Tyrakis et al.   NATURE

IL-7-Induced Glycerol Transport and TAG Synthesis Promotes Memory CD8+ T Cell Longevity

(2015) Guoliang Cui et al.   CELL

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

(2015) Manish Sud et al.   NUCLEIC ACIDS RESEARCH

Fatty acid metabolism in the regulation of T cell function

(2015) Matthias Lochner et al.   TRENDS IN IMMUNOLOGY

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma

(2015) Maria Inés Molejon et al.   Oncotarget

The Shared and Contrasting Roles of IL2 and IL15 in the Life and Death of Normal and Neoplastic Lymphocytes: Implications for Cancer Therapy

(2015) T. A. Waldmann   Cancer Immunology Research

A Novel Method for Assessment of Natural Killer Cell Cytotoxicity Using Image Cytometry

(2015) Srinivas S. Somanchi et al.   PLoS One

Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

NK cell development and function – Plasticity and redundancy unleashed

(2014) Frank Cichocki et al.   SEMINARS IN IMMUNOLOGY

The Critical Role of IL-15–PI3K–mTOR Pathway in Natural Killer Cell Effector Functions

(2014) Neethi Nandagopal et al.   Frontiers in Immunology

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Differential Localization of T-bet and Eomes in CD8 T Cell Memory Populations

(2013) L. M. McLane et al.   JOURNAL OF IMMUNOLOGY

Optimization of tumor xenograft dissociation for the profiling of cell surface markers and nutrient transporters

(2013) Vincent Petit et al.   LABORATORY INVESTIGATION

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

(2008) Nicholas D. Huntington et al.   JOURNAL OF EXPERIMENTAL MEDICINE