Journal
NUCLEIC ACIDS RESEARCH
Volume 50, Issue W1, Pages W527-W533Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkac376
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Funding
- Genome Canada
- Genome Quebec
- Canada Research Chairs
- Natural Sciences and Engineering Research Council of Canada
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Researchers are using OmicsNet to interpret molecular data within a multi-omics context, facilitating hypothesis generation and mechanistic insights.
Researchers are increasingly seeking to interpret molecular data within a multi-omics context to gain a more comprehensive picture of their study system. OmicsNet (www.omicsnet.ca) is a web-based tool developed to allow users to easily build, visualize, and analyze multi-omics networks to study rich relationships among lists of `omics features of interest. Three major improvements have been introduced in OmicsNet 2.0, which include: (i) enhanced network visual analytics with eleven 2D graph layout options and a novel 3D module layout; (ii) support for three new `omics types: single nucleotide polymorphism (SNP) list from genetic variation studies; taxon list from microbiome profiling studies, as well as liquid chromatography-mass spectrometry (LC-MS) peaks from untargeted metabolomics; and (iii) measures to improve research reproducibility by coupling R command history with the release of the companion OmicsNetR package, and generation of persistent links to share interactive network views. We performed a case study using the multi-omics data obtained from a recent large-scale investigation on inflammatory bowel disease (IBD) and demonstrated that OmicsNet was able to quickly create meaningful multi-omics context to facilitate hypothesis generation and mechanistic insights. [GRAPHICS] .
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