Anti-high-mobility group box-1 treatment strategies improve trauma-induced coagulopathy in a mouse model of trauma and shock

VhH anti‐thrombomodulin clone 1 inhibits TAFI activation and enhances fibrinolysis in human whole blood under flow

(2022) Marc V.A. van Moorsel et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in Trauma

(2022) Zhangsheng Yang et al.   Biomolecules

The effect of shock duration on trauma-induced coagulopathy in a murine model

(2022) Pieter H. Sloos et al.   Intensive Care Medicine Experimental

Platelet dysfunction after trauma: From mechanisms to targeted treatment

(2022) Pieter H. Sloos et al.   TRANSFUSION

Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients

(2020) Paul Vulliamy et al.   Blood Advances

Thrombomodulin as a Physiological Modulator of Intravascular Injury

(2020) Kanako Watanabe-Kusunoki et al.   Frontiers in Immunology

Platelets retain inducible alpha granule secretion by P‐selectin expression but exhibit mechanical dysfunction during trauma‐induced coagulopathy

(2019) Alexander E. St. John et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage

(2019) Paul Vulliamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deep vein thrombosis in mice is regulated by platelet HMGB1 through release of neutrophil-extracellular traps and DNA

(2018) Mitchell R. Dyer et al.   Scientific Reports

Trends in potentially preventable trauma deaths between 2005-2006 and 2012–2013

(2018) Ezra Y. Koh et al.   AMERICAN JOURNAL OF SURGERY

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Gregory A Roth et al.   LANCET

Trends in 1029 trauma deaths at a level 1 trauma center: Impact of a bleeding control bundle of care

(2017) Blessing T. Oyeniyi et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Development and validation of a high throughput whole blood thrombolysis plate assay

(2017) T. Bonnard et al.   Scientific Reports

Platelet-derived high-mobility group box 1 promotes recruitment and suppresses apoptosis of monocytes

(2016) Sebastian Vogel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prognostic value of HMGB1 and oxidative stress markers in multiple trauma patients: A single-centre prospective study

(2016) Francesca Polito et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

A prospective study of platelet function in trauma patients

(2016) Matthew T. Ramsey et al.   Journal of Trauma and Acute Care Surgery

A prospective study of platelet function in trauma patients

(2016) Matthew T. Ramsey et al.   Journal of Trauma and Acute Care Surgery

HMGB1: a novel protein that induced platelets active and aggregation via Toll-like receptor-4, NF-κB and cGMP dependent mechanisms

(2015) Xinyu Yang et al.   Diagnostic Pathology

Platelet-derived HMGB1 is a critical mediator of thrombosis

(2015) Sebastian Vogel et al.   JOURNAL OF CLINICAL INVESTIGATION

HMGB1 binds to activated platelets via the receptor for advanced glycation end products and is present in platelet rich human coronary artery thrombi

(2015) Michael Bode et al.   THROMBOSIS AND HAEMOSTASIS

Time course of soluble P-selectin and von Willebrand factor levels in trauma patients: a prospective observational study

(2013) Ning Tang et al.   Scandinavian Journal of Trauma Resuscitation & Emergency Medicine

Early Platelet Dysfunction: An Unrecognized Role in the Acute Coagulopathy of Trauma

(2012) Max V. Wohlauer et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Characterization of platelet dysfunction after trauma

(2012) Matthew E. Kutcher et al.   Journal of Trauma and Acute Care Surgery

Human Thrombomodulin Knock-In Mice Reveal Differential Effects of Human Thrombomodulin on Thrombosis and Atherosclerosis

(2011) Thomas J. Raife et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pattern of release and relationship between HMGB-1 and IL-6 following blunt trauma

(2010) Peter V. Giannoudis et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Generation of Monoclonal Antibodies against Highly Conserved Antigens

(2009) Hongzhe Zhou et al.   PLoS One

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

(2009) Erik D. Peltz et al.   SHOCK

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes

(2008) Takashi Ito et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY