NMDA Receptor Activation Stimulates Hypoxia-Induced TRPM2 Channel Activation, Mitochondrial Oxidative Stress, and Apoptosis in Neuronal Cell Line: Modular Role of Memantine

A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol

(2022) Mustafa Nazıroğlu   METABOLIC BRAIN DISEASE

Amantadine Attenuated Hypoxia-Induced Mitochondrial Oxidative Neurotoxicity, Apoptosis, and Inflammation via the Inhibition of TRPM2 and TRPV4 Channels

(2022) Özgür Öcal et al.   MOLECULAR NEUROBIOLOGY

Functional coupling of TRPM2 and extrasynaptic NMDARs exacerbates excitotoxicity in ischemic brain injury

(2022) Pengyu Zong et al.   NEURON

Involvement of TRPM2 Channel on Hypoxia-Induced Oxidative Injury, Inflammation, and Cell Death in Retinal Pigment Epithelial Cells: Modulator Action of Selenium Nanoparticles

(2021) Dilek Özkaya et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Memantine ameliorates cognitive impairment induced by exposure to chronic hypoxia environment at high altitude by inhibiting excitotoxicity

(2021) Weizhong Ji et al.   LIFE SCIENCES

Pretreatment with mGluR2 or mGluR3 Agonists Reduces Apoptosis Induced by Hypoxia-Ischemia in Neonatal Rat Brains

(2021) Ewelina Bratek - Gerej et al.   Oxidative Medicine and Cellular Longevity

Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway

(2021) Yuqin Wu et al.   INFLAMMATION

Dexmedetomidine inhibits inflammatory response and oxidative stress through regulating miR-205-5p by targeting HMGB1 in cerebral ischemic/reperfusion

(2021) Jun-jun Yang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

The involvement of TRPV4 on the hypoxia-induced oxidative neurotoxicity and apoptosis in a neuronal cell line: Protective role of melatonin

(2021) Ahmet Özşimşek et al.   NEUROTOXICOLOGY

Protective role of selenium on MPP+ and homocysteine-induced TRPM2 channel activation in SH-SY5Y cells

(2021) Kenan Yıldızhan et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Microglial NMDA receptors drive pro‐inflammatory responses via PARP‐1/TRMP2 signaling

(2020) Prajwal Raghunatha et al.   GLIA

Neuroprotective Effect of New Nanochelating-Based Nano Complex, ALZc3, Against Aβ (1–42)-Induced Toxicity in Rat: a Comparison with Memantine

(2020) Ramin Karimi-Sales et al.   PHARMACEUTICAL RESEARCH

Resveratrol attenuates hypoxia-induced neuronal cell death, inflammation and mitochondrial oxidative stress by modulation of TRPM2 channel

(2020) Yener Akyuva et al.   Scientific Reports

Effects of homocysteine and memantine on oxidative stress related TRP cation channels in in-vitro model of Alzheimer’s disease

(2020) İshak Suat Övey et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia

(2020) Kenan Yıldızhan et al.   MOLECULAR NEUROBIOLOGY

N-Acetylaspartylglutamate (NAAG) Pretreatment Reduces Hypoxic-Ischemic Brain Damage and Oxidative Stress in Neonatal Rats

(2020) Ewelina Bratek et al.   Antioxidants

Curcumin Attenuates Hypoxia-Induced Oxidative Neurotoxicity, Apoptosis, Calcium, and Zinc Ion Influxes in a Neuronal Cell Line: Involvement of TRPM2 Channel

(2020) Hamit Hakan Armağan et al.   NEUROTOXICITY RESEARCH

Overshooting Subcellular Redox-Responses in Rett-Mouse Hippocampus during Neurotransmitter Stimulation

(2020) Karina Festerling et al.   Cells

Vildagliptine protects SH-SY5Y human neuron-like cells from Aβ 1–42 induced toxicity, in vitro

(2019) Alim Hüseyin Dokumacı et al.   CYTOTECHNOLOGY

NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease

(2019) Michela Rosini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Blood–Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke

(2017) Poornima Venkat et al.   Journal of the American Heart Association

TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells

(2016) Hisa Hui Ling Tseng et al.   Scientific Reports

The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels

(2016) Hatice Akpınar et al.   Scientific Reports

CIH-induced neurocognitive impairments are associated with hippocampal Ca2+ overload, apoptosis, and dephosphorylation of ERK1/2 and CREB that are mediated by overactivation of NMDARs

(2015) Jing Wang et al.   BRAIN RESEARCH

Pretreatment with baicalin attenuates hypoxia and glucose deprivation-induced injury in SH-SY5Y cells

(2015) Qing-bo Zhou et al.   Chinese Journal of Integrative Medicine

The Zinc Ion Chelating Agent TPEN Attenuates Neuronal Death/apoptosis Caused by Hypoxia/ischemia Via Mediating the Pathophysiological Cascade Including Excitotoxicity, Oxidative Stress, and Inflammation

(2015) Wei-Ming Wang et al.   CNS Neuroscience & Therapeutics

Compound MQA, a Caffeoylquinic Acid Derivative, Protects Against NMDA-Induced Neurotoxicity and Potential MechanismsIn Vitro

(2015) Xing Tian et al.   CNS Neuroscience & Therapeutics

N-acetyl cysteine reduces oxidative toxicity, apoptosis, and calcium entry through TRPV1 channels in the neutrophils of patients with polycystic ovary syndrome

(2015) S. A. Köse et al.   FREE RADICAL RESEARCH

Calcium Ion – The Key Player in Cerebral Ischemia

(2014) V.S. Kumar et al.   CURRENT MEDICINAL CHEMISTRY

Electromagnetic radiation (Wi-Fi) and epilepsy induce calcium entry and apoptosis through activation of TRPV1 channel in hippocampus and dorsal root ganglion of rats

(2014) Vahid Ghazizadeh et al.   METABOLIC BRAIN DISEASE

Modulation of NMDAR Subunit Expression by TRPM2 Channels Regulates Neuronal Vulnerability to Ischemic Cell Death

(2013) I. Alim et al.   JOURNAL OF NEUROSCIENCE

The Oxygen Free Radicals Originating from Mitochondrial Complex I Contribute to Oxidative Brain Injury Following Hypoxia-Ischemia in Neonatal Mice

(2012) Z. V. Niatsetskaya et al.   JOURNAL OF NEUROSCIENCE

Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

(2012) Jillian C Belrose et al.   Molecular Brain

Low-Dose Memantine Attenuated Morphine Addictive Behavior Through its Anti-Inflammation and Neurotrophic Effects in Rats

(2011) Shiou-Lan Chen et al.   Journal of Neuroimmune Pharmacology

Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells

(2011) Ignacio Bejarano et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Differentiation of HT22 neurons induces expression of NMDA receptor that mediates homocysteine cytotoxicity

(2011) Zhongyan Zhao et al.   NEUROLOGICAL RESEARCH

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

(2011) Brian Leonard et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria

(2011) Vera C. Keil et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Dependence of NMDA/GSK-3β Mediated Metaplasticity on TRPM2 Channels at Hippocampal CA3-CA1 Synapses

(2011) Yu-Feng Xie et al.   Molecular Brain

Hypoxia. 1. Intracellular sensors for oxygen and oxidative stress: novel therapeutic targets

(2010) Toshio Miyata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sustained calcium signalling and caspase-3 activation involve NMDA receptors in thymocytes in contact with dendritic cells

(2010) P Affaticati et al.   CELL DEATH AND DIFFERENTIATION

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Transient Receptor Potential Melastatin 2 Expression is Increased Following Experimental Traumatic Brain Injury in Rats

(2010) Naomi L. Cook et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

TRPM2 Cation Channels, Oxidative Stress and Neurological Diseases: Where Are We Now?

(2010) Mustafa Nazıroğlu   NEUROCHEMICAL RESEARCH

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

(2008) K Togashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Calcium Influx Pathway Regulated Separately by Oxidative Stress and ADP-Ribose in TRPM2 Channels: Single Channel Events

(2008) Mustafa Nazıroğlu et al.   NEUROCHEMICAL RESEARCH

Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid

(2006) Robert Kraft et al.   BRITISH JOURNAL OF PHARMACOLOGY