Roles of N-linked glycosylation and glycan-binding proteins in placentation: trophoblast infiltration, immunomodulation, angiogenesis, and pathophysiology

Pregnancy-specific glycoproteins: evolution, expression, functions and disease associations

(2022) Tom Moore et al.   REPRODUCTION

Immunobiology of Gestational Diabetes Mellitus in Post-Medawar Era

(2022) Surendra Sharma et al.   Frontiers in Immunology

Role of osteopontin (OPN) in uterine spiral artery remodeling

(2022) Yue Pan et al.   PLACENTA

Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin

(2021) Miaomiao Wang et al.   Frontiers in Cell and Developmental Biology

Allotype-Specific Glycosylation and Cellular Localization of Human Leukocyte Antigen Class I Proteins

(2021) Max Hoek et al.   JOURNAL OF PROTEOME RESEARCH

Extracellularly Released Calreticulin Induced by Endoplasmic Reticulum Stress Impairs Syncytialization of Cytotrophoblast Model BeWo Cells

(2021) Naoyuki Iwahashi et al.   Cells

Galectins in Early Pregnancy and Pregnancy-Associated Pathologies

(2021) Milica Jovanović Krivokuća et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The expression and role of glycans at the feto-maternal interface in humans

(2021) Sofia Passaponti et al.   TISSUE & CELL

Medawar’s PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation

(2021) Ellen Menkhorst et al.   Frontiers in Immunology

Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues

(2021) Jennifer D. Kaminker et al.   Biomolecules

Insights into the hyperglycosylation of human chorionic gonadotropin revealed by glycomics analysis

(2020) Linda Ibeto et al.   PLoS One

Placental Protein 13 (Galectin-13) Polarizes Neutrophils Toward an Immune Regulatory Phenotype

(2020) Lenka Vokalova et al.   Frontiers in Immunology

Biological and Technical Challenges in Unraveling the Role of N-Glycans in Immune Receptor Regulation

(2020) Paola de Haas et al.   Frontiers in Chemistry

Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T‐cell differentiation along the maternal‐placental circulation

(2020) Yeling Ma et al.   CELL PROLIFERATION

Placental Galectin-2 Expression in Gestational Diabetes: A Systematic, Histological Analysis

(2020) Paula Hepp et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

(2020) Sara Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human T cell glycosylation and implications on immune therapy for cancer

(2020) Elien De Bousser et al.   Human Vaccines & Immunotherapeutics

The chimera‐type galectin‐3 is a positive modulator of trophoblast functions with dysregulated expression in gestational diabetes mellitus

(2020) Nancy Freitag et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Galectin-3 deficiency in pregnancy increases the risk of fetal growth restriction (FGR) via placental insufficiency

(2020) Nancy Freitag et al.   Cell Death & Disease

Altered Glycosylation Contributes to Placental Dysfunction Upon Early Disruption of the NK Cell-DC Dynamics

(2020) Sophia Borowski et al.   Frontiers in Immunology

Glycosylated Siglec-6 expression in syncytiotrophoblast-derived extracellular vesicles from preeclampsia placentas

(2020) Toluwalase Awoyemi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human trophoblast requires galectin-3 for cell migration and invasion

(2019) Ž. Bojić-Trbojević et al.   Scientific Reports

Fc Glycan-Mediated Regulation of Placental Antibody Transfer

(2019) Madeleine F. Jennewein et al.   CELL

Human placenta and trophoblast development: key molecular mechanisms and model systems

(2019) Martin Knöfler et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Galectin 13 (PP13) Facilitates Remodeling and Structural Stabilization of Maternal Vessels during Pregnancy

(2019) Marei Sammar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins

(2019) Sandra M. Blois et al.   Frontiers in Immunology

Placental Galectins Are Key Players in Regulating the Maternal Adaptive Immune Response

(2019) Andrea Balogh et al.   Frontiers in Immunology

Development of the human placenta

(2019) Margherita Y. Turco et al.   DEVELOPMENT

Dysregulation of Placental Functions and Immune Pathways in Complete Hydatidiform Moles

(2019) Jennifer R. King et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycoanalysis of the placental membrane glycoproteins throughout placental development

(2019) Dragana Robajac et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Interaction of Pregnancy-Specific Glycoprotein 1 With Integrin Α5β1 Is a Modulator of Extravillous Trophoblast Functions

(2019) Rattila et al.   Cells

Downregulated N-acetylglucosaminyltransferase III is involved in attenuating trophoblast migration and invasion under hypoxia–reoxygenation condition

(2018) Qinyin Deng et al.   Journal of Maternal-Fetal & Neonatal Medicine

Conserved FcγR- glycan discriminates between fucosylated and afucosylated IgG in humans and mice

(2018) Gillian Dekkers et al.   MOLECULAR IMMUNOLOGY

Reduced placental protein 13 (PP13) in placental derived syncytiotrophoblast extracellular vesicles in preeclampsia – A novel tool to study the impaired cargo transmission of the placenta to the maternal organs

(2018) Marei Sammar et al.   PLACENTA

Expression of N-Acetylglucosaminyltransferase III Promotes Trophoblast Invasion and Migration in Early Human Placenta

(2018) Qinyin Deng et al.   Reproductive Sciences

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

FUT8 drives the proliferation and invasion of trophoblastic cells via IGF-1/IGF-1R signaling pathway

(2018) Ming Yu et al.   PLACENTA

Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin β1

(2017) Madoka Yamamoto et al.   ENDOCRINOLOGY

Placental protein 13 (PP13)-induced vasodilation of resistance arteries from pregnant and nonpregnant rats occurs via endothelial-signaling pathways

(2017) Tijana Drobnjak et al.   HYPERTENSION IN PREGNANCY

Integrin β1 is bound to galectin-1 in human trophoblast

(2017) Žanka Bojić-Trbojević et al.   JOURNAL OF BIOCHEMISTRY

Update of syncytiotrophoblast derived extracellular vesicles in normal pregnancy and preeclampsia

(2017) Dionne Tannetta et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

(2017) Kimihiro Nishino et al.   ONCOLOGY REPORTS

Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs

(2017) Juan P. Cerliani et al.   TRENDS IN BIOCHEMICAL SCIENCES

Decoding the Human Immunoglobulin G-Glycan Repertoire Reveals a Spectrum of Fc-Receptor- and Complement-Mediated-Effector Activities

(2017) Gillian Dekkers et al.   Frontiers in Immunology

Mechanisms of disease: The human N-glycome

(2016) Gordan Lauc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Expression ofN-Acetylglucosaminyltransferase III Suppresses α2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to α2,6-Sialylation Levels

(2016) Jishun Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for Differential Glycosylation of Trophoblast Cell Types

(2016) Qiushi Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

The human fetoembryonic defense system hypothesis: Twenty years on

(2016) Poh-Choo Pang et al.   MOLECULAR ASPECTS OF MEDICINE

Differences of glycocalyx composition in the structural elements of placenta in preeclampsia

(2016) G.T. Sukhikh et al.   PLACENTA

The Role of MGAT5 in Human Umbilical Vein Endothelial Cells

(2016) Qinyin Deng et al.   Reproductive Sciences

N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4

(2016) Qinglei Hang et al.   Scientific Reports

Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway

(2016) Jintang Sun et al.   PLoS One

The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal–fetal interface in early pregnancy

(2015) Yan-Hong Li et al.   Cellular & Molecular Immunology

Altered β1,6-GlcNAc and bisecting GlcNAc-branched N-glycan on integrin β1 are associated with early spontaneous miscarriage in humans

(2015) Min Zhang et al.   HUMAN REPRODUCTION

Review: hCGs: Different sources of production, different glycoforms and functions

(2015) T. Fournier et al.   PLACENTA

β-1,4-galactosyltransferase III suppresses extravillous trophoblast invasion through modifying β1-integrin glycosylation

(2015) W.-C. Liao et al.   PLACENTA

N-acetylglucosaminyltransferase V inhibits the invasion of trophoblast cells by attenuating MMP2/9 activity in early human pregnancy

(2015) Qinyin Deng et al.   PLACENTA

HCG-Activated Human Peripheral Blood Mononuclear Cells (PBMC) Promote Trophoblast Cell Invasion

(2015) Nan Yu et al.   PLoS One

The N-glycan profile of placental membrane glycoproteins alters during gestation and aging

(2014) Dragana Robajac et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Getting too sweet: galectin-1 dysregulation in gestational diabetes mellitus

(2014) S. M. Blois et al.   MOLECULAR HUMAN REPRODUCTION

Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage

(2014) E.M. Menkhorst et al.   PLACENTA

Placental Protein 13 (PP13) – A Placental Immunoregulatory Galectin Protecting Pregnancy

(2014) Nándor Gábor Than et al.   Frontiers in Immunology

Effects of Placental Protein 13 on the Cardiovascular System in Gravid and Non-Gravid Rodents

(2013) Sveinbjorn Gizurarson et al.   FETAL DIAGNOSIS AND THERAPY

Human chorionic gonadotropin (hCG) modulation of TIMP1 secretion by human endometrial stromal cells facilitates extravillous trophoblast invasion in vitro

(2013) A. Tapia-Pizarro et al.   HUMAN REPRODUCTION

Human chorionic gonadotropin and its free β-subunit stimulate trophoblast invasion independent of LH/hCG receptor

(2013) Cheuk-Lun Lee et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The role of glycans in immune evasion: the human fetoembryonic defence system hypothesis revisited

(2013) Gary F. Clark   MOLECULAR HUMAN REPRODUCTION

Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice

(2013) S M Blois et al.   Mucosal Immunology

Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia

(2013) N. Freitag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High expression of N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma

(2012) K Niimi et al.   BRITISH JOURNAL OF CANCER

Overexpression of Calreticulin in Pre-eclamptic Placentas: Effect on Apoptosis, Cell Invasion and Severity of Pre-eclampsia

(2012) Zhonghua Shi et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Galectin-1 confers immune privilege to human trophoblast: implications in recurrent fetal loss

(2012) R. E. Ramhorst et al.   GLYCOBIOLOGY

Comparison of the Fc glycosylation of fetal and maternal immunoglobulin G

(2012) Helga K. Einarsdottir et al.   GLYCOCONJUGATE JOURNAL

Galectin-1 influences trophoblast immune evasion and emerges as a predictive factor for the outcome of pregnancy

(2012) I. Tirado-Gonzalez et al.   MOLECULAR HUMAN REPRODUCTION

Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy

(2012) Yujie Cui et al.   NATURE

Siglec-6 Expression Is Increased in Placentas From Pregnancies Complicated by Preterm Preeclampsia

(2012) Kristen K. Rumer et al.   Reproductive Sciences

Roles for major histocompatibility complex glycosylation in immune function

(2012) Sean O. Ryan et al.   Seminars in Immunopathology

Distribution of sugar residues in human placentas from pregnancies complicated by hypertensive disorders

(2011) Mirca Marini et al.   ACTA HISTOCHEMICA

Elimination of Complement Interference in Immunoassay of Hyperglycosylated Human Chorionic Gonadotropin

(2011) U.-H. Stenman et al.   CLINICAL CHEMISTRY

Glycosylation Failure Extends to Glycoproteins in Gestational Diabetes Mellitus

(2011) Cheuk-Lun Lee et al.   DIABETES

Glycodelin-A Protein Interacts with Siglec-6 Protein to Suppress Trophoblast Invasiveness by Down-regulating Extracellular Signal-regulated Kinase (ERK)/c-Jun Signaling Pathway

(2011) Kevin K. W. Lam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-8 is expressed by villous and extravillous trophoblast of the human placenta

(2011) N. Kolundžić et al.   PLACENTA

Placenta-bound and Body Fluid PP13 and its mRNA in Normal Pregnancy Compared to Preeclampsia, HELLP and Preterm Delivery

(2011) M. Sammar et al.   PLACENTA

Galectin-1 Is Part of Human Trophoblast Invasion Machinery - A Functional Study In Vitro

(2011) Nikola Kolundžić et al.   PLoS One

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Placental Protein 13 and Decidual Zones of Necrosis: An Immunologic Diversion That May be Linked to Preeclampsia

(2011) Harvey J. Kliman et al.   Reproductive Sciences

Human Pregnancy Specific Beta-1-Glycoprotein 1 (PSG1) Has a Potential Role in Placental Vascular Morphogenesis1

(2010) Cam T. Ha et al.   BIOLOGY OF REPRODUCTION

Pregnancy-specific Glycoprotein 1 Induces Endothelial Tubulogenesis through Interaction with Cell Surface Proteoglycans

(2010) Felipe A. Lisboa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperglycosylated hCG Is a Marker of Early Human Trophoblast Invasion

(2010) J. Guibourdenche et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Stimulation of Syncytium Formation in vitro in Human Trophoblast Cells by Galectin-1

(2010) I. Fischer et al.   PLACENTA

N-Glycosylation of the I-like Domain of β1 Integrin Is Essential for β1 Integrin Expression and Biological Function

(2009) Tomoya Isaji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The repertoire of glycan determinants in the human glycome

(2009) Richard D. Cummings   Molecular BioSystems

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death

(2009) N. G. Than et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-trimester maternal serum PP13 in the risk assessment for preeclampsia

(2008) Roberto Romero et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

N-Acetylglucosaminyltransferase V Regulates Extravillous Trophoblast Invasion through Glycosylation of α5β1 Integrin

(2008) Eiko Yamamoto et al.   ENDOCRINOLOGY

N-Linked Glycosylation Selectively Regulates the Generic Folding of HLA-Cw1

(2008) Aline Martayan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-7 in the Control of Epidermal Homeostasis after Injury

(2008) Gaëlle Gendronneau et al.   MOLECULAR BIOLOGY OF THE CELL

Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome

(2008) Nandor Gabor Than et al.   VIRCHOWS ARCHIV

Human Chorionic Gonadotropin Stimulates Trophoblast Invasion through Extracellularly Regulated Kinase and AKT Signaling

(2007) Johanna Prast et al.   ENDOCRINOLOGY