Article
Biochemistry & Molecular Biology
Jia-Mei Luo, Tong-Tong Zhang, Yu-Ying He, Hui-Na Luo, Yu-Qi Hong, Zeng-Ming Yang
Summary: Decidualization is crucial for early pregnancy in rodents and humans. Disturbed decidualization can lead to implantation failure, spontaneous abortion, and preeclampsia. This study demonstrates that IL4I1-catalyzed metabolites of Trp enhance human decidualization through the AHR-Epiregulin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Ernesto Bosch, Martin Hund, Reinhard van der Does, Laura Caracena, Silke Ahlers, Elena Labarta
Summary: The study aimed to compare the measurement of hHCG and HCG+beta for early pregnancy detection after IVF and embryo transfer. The results showed that the predictive performance of both biomarkers was similar at different time points, and the diagnostic performance improved from day 4 to day 11.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Chemistry, Analytical
Bei Zhang, Miao Guo, Tianjie Zhang, Dandan Liu, Xin Tan, Xue Li, Yang Yu, Huiqiang Li
Summary: Early pregnancy prediction requires high sensitivity in beta-hCG detection, while embryonic development monitoring and trophoblastic disease detection require a wider detection range. In this study, a light-initiated chemiluminescence assay (LICA) was used with immobilized monoclonal antibodies (mAbs) of different affinities to detect beta-hCG. The assay showed high sensitivity, good linearity, and correlation with a standard assay, making it a reliable method for beta-hCG detection.
ANALYTICAL METHODS
(2022)
Article
Medicine, General & Internal
Ying Liu, Xiao-Ya Ren, Ya-Guang Peng, Shao-Ke Chen, Xin-Ran Cheng, Miao Qin, Xiao-Ling Wang, Yan-Ning Song, Li-Jun Fan, Chun-Xiu Gong
Summary: The study demonstrated that hCG/hMG therapy is feasible and effective for treating male adolescents with CHH, with the initial 3 months of treatment showing the strongest effects. Results from the extended time-period also showed positive outcomes at the 1-year mark, indicating the potential of hCG/hMG regimen, although further research is needed to assess its long-term effectiveness and limitations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medical Laboratory Technology
Christopher J. Mattiello, Douglas F. Stickle
Summary: We used image analysis to characterize the dose vs response curve of a qualitative serum hCG lateral flow immunoassay, which helped us understand the transition from negative to positive. The results showed that the curve could be described by a simple hyperbola equation, which was useful for verifying the assay's performance characteristics.
CLINICA CHIMICA ACTA
(2023)
Article
Agriculture, Dairy & Animal Science
E. M. Cabrera, M. R. Lauber, T. Valdes-Arciniega, M. S. El Azzi, J. P. N. Martins, T. R. Bilby, P. M. Fricke
Summary: The study aimed to compare the effects of GnRH and hCG treatments on pregnancies per artificial insemination in lactating dairy cows. The results showed that cows treated with GnRH had higher pregnancy rates and there were no significant differences in ovulation time and luteolysis completeness between GnRH and hCG treatments.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Xue Wang, Chao-Hua Xue, Dong Yang, Shun-Tian Jia, Ya-Ru Ding, Lei Lei, Ke-Yi Gao, Tong-Tong Jia
Summary: By coating the nitrocellulose membrane with electrospun fibers, the sensitivity of detecting HCG and LH can be enhanced with detection limits of 0.22 and 0.36 mIU mL(-1) respectively, within a quantitative linear range of 0.5-500 mIU mL(-1). Results demonstrate the effectiveness of electrospinning in modifying conventional NC membranes for LFA applications.
Article
Medicine, Research & Experimental
Danbi Lee, Yu-Gyeong Lee, Jieun Won, Seon-Hwa Hong, Jee Hyun Kim, Youn-Jung Kang
Summary: This study aimed to investigate the optimal timing of hCG administration to enhance embryo implantation rates. The results showed that hCG administration induced a significant increase in endometrial receptivity and angiogenesis-related gene expression levels within 72 hours, and promoted the stability of embryo attachment in an in vitro model.
Article
Immunology
Liyan Wang, Yanbiao Jiang, Haofei Shen, Xiaoling Ma, Mingxia Gao, Panpan Jin, Rui Zhang, Lihui Zhao, Xuehong Zhang
Summary: The serum beta-hCG level after 14 days of embryo transfer has a strong independent predictive value for the occurrence of early pregnancy loss in fresh IVF/ICSI cycles.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Xue Wang, Huanyuan Wang, Yingying Sun, Zhe Liu, Na Wang
Summary: This study presents a liquid crystal biosensor using Au nanoparticles for signal amplification to detect HCG antigen in a micro and cost-effective manner. The sensor utilizes the unique properties of LC for HCG detection, providing excellent sensitivity and low detection limits.
Article
Medicine, General & Internal
Allison A. Gockley, Lawrence H. Lin, Michelle Davis, Alexander Melamed, Anthony Rizzo, Sue Yazaki Sun, Kevin Elias, Donald P. Goldstein, Ross S. Berkowitz, Neil S. Horowitz
Summary: This study found that age and race/ethnicity did not affect hCG regression rates, while obesity and hormonal contraceptive use were associated with faster hCG regression rates, although clinically insignificant. Understanding how clinical characteristics may influence hCG regression curve is important for predicting the risk of gestational trophoblastic neoplasia.
Article
Chemistry, Analytical
Hatem Mohamed Elsheikh, Shadia Abdel-Hamid Fathy, Nahed Hassan Ebeid, Khaled Mohamed Sallam, Ahmed Sami El-bayoumy, Nagy Lahzy Mehany, Germine Mohsen Hamdy
Summary: The main objective of this study was to prepare and evaluate primary reagents for the liquid phase human chorionic gonadotropin-radioimmunoassay (HCG-RIA) kit. Polyclonal antibodies were found to be specific and valid, while monoclonal antibodies were more specific. The developed in-house HCG-RIA method showed high sensitivity, specificity, precision, and accuracy, making it suitable for quantifying HCG in human sera for pregnancy monitoring and diagnosis of gestational trophoblastic diseases.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Kiwamu Noshiro, Takeshi Umazume, Rifumi Hattori, Soromon Kataoka, Takashi Yamada, Hidemichi Watari
Summary: This study found that serum ketone levels peak in the third trimester of pregnancy, but do not directly correlate with neonatal body shape. Weight loss during pregnancy may be related to morning sickness, with a higher pre-pregnancy body mass index leading to greater weight loss.
Article
Oncology
Qing Cong, Ling Lin, Biao Qi, Congjian Xu, Xiaoyan Zhang
Summary: The study developed an active targeted therapeutic system that efficiently delivered chemotherapy drug MTX to choriocarcinoma cells through HCG receptor mediation, significantly improving chemotherapy efficacy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Infectious Diseases
M. Gunell, P. Antikainen, N. Porjo, K. Irjala, J. Vakkila, K. Hotakainen, S. S. Kaukoranta, J. J. Hirvonen, K. Saha, R. Manninen, B. Forsblom, K. Rantakokko-Jalava, V. Peltola, J. O. Koskinen, P. Huovinen
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2016)
Article
Public, Environmental & Occupational Health
Matti Hakama, Sue M. Moss, Ulf-Hakan Stenman, Monique J. Roobol, Marco Zappa, Sigrid Carlsson, Marco Randazzo, Vera Nelen, Jonas Hugosson
JOURNAL OF MEDICAL SCREENING
(2017)
Article
Obstetrics & Gynecology
Elina Keikkala, Sini Koskinen, Piia Vuorela, Hannele Laivuori, Jarkko Romppanen, Seppo Heinonen, Ulf-Hakan Stenman
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Cell Biology
Helene M. Markkanen, Tuula Pekkarinen, Esa Hamalainen, Matti J. Valimaki, Henrik Alfthan, Ulf-Hakan Stenman
GROWTH HORMONE & IGF RESEARCH
(2017)
Article
Medicine, General & Internal
P. Simonen, J. Lehtonen, A. -M. Lampi, V. Piironen, U. -H. Stenman, M. Kupari, H. Gylling
JOURNAL OF INTERNAL MEDICINE
(2018)
Article
Urology & Nephrology
Teemu J. Murtola, Anniina Virkku, Kirsi Talala, Ulf-Hakan Stenman, Kimmo Taari, Teuvo L. J. Tammela, Anssi Auvinen
JOURNAL OF UROLOGY
(2017)
Article
Obstetrics & Gynecology
Mariann Koel, Urmo Vosa, Kaarel Krjutskov, Elisabet Einarsdottir, Juha Kere, Juha Tapanainen, Shintaro Katayama, Sulev Ingerpuu, Viljar Jaks, Ulf-Hakan Stenman, Karolina Lundin, Timo Tuuri, Andres Salumets
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Article
Medicine, Research & Experimental
Susanna Lintula, Tuomas Mirtti, Antti Rannikko, Anna Butzow, Anna Lempiainen, Jakob Stenman, Ulf-Hakan Stenman, Kristina Hotakainen
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2019)
Article
Medicine, Research & Experimental
Juhani A. Stewart, Riitta Koistinen, Anna Lempiainen, Kristina Hotakainen, Ulla-Stina Salminen, Anne Vakkuri, Johanna Wennervirta, Ulf-Hakan Stenman, Hannu Koistinen
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
(2020)
Editorial Material
Health Care Sciences & Services
Svein R. Kjosavik, Karina Dalsgaard Sorensen, Kristina Hotakainen, Henrik Gronberg
SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
(2020)
Article
Multidisciplinary Sciences
Juha M. Koskinen, Petri Antikainen, Kristina Hotakainen, Anu Haveri, Niina Ikonen, Carita Savolainen-Kopra, Kati Sundstrom, Janne O. Koskinen
Summary: The global ramp-up of COVID-19 diagnostics in early 2020 focused on detecting viral RNA. The novel mariPOC SARS-CoV-2 test, utilizing optical laser technology, showed high sensitivity and specificity with the ability to detect infectious individuals within 20 minutes.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Elisabeth Widen, Nella Junna, Sanni Ruotsalainen, Ida Surakka, Nina Mars, Pietari Ripatti, Juulia J. Partanen, Johanna Aro, Pekka Mustonen, Tiinamaija Tuomi, Aarno Palotie, Veikko Salomaa, Jaakko Kaprio, Jukka Partanen, Kristina Hotakainen, Pasi Pollanen, Samuli Ripatti
Summary: Prediction tools that combine polygenic risk scores with clinical factors can improve the prediction and prevention of atherosclerotic cardiovascular disease. Returning personal risk information via web-based communication motivates positive changes in health behavior and the propensity to seek care.
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2022)
Article
Biochemical Research Methods
Hannu Koistinen, Riitta Koistinen, Kristina Hotakainen, Anna Lempiainen, Kalle Jokelainen, Martti Farkkila, Ulf-Hakan Stenman
Summary: This study identified the composition and variants of trypsin and developed a specific assay. The experiment showed that trypsinogen-4 can be found in certain cell lines and bile samples, but the clinical utility of the assay remains uncertain.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Oncology
Jaakko Nevalainen, Ulf-Hakan Stenman, Teuvo L. Tammela, Monique Roobol, Sigrid Carlssone, Kirsi Talalag, Fritz H. Schroder, Anssi Auvinen
CANCER EPIDEMIOLOGY
(2017)
