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Title
Allosteric regulation and inhibition of protein kinases
Authors
Keywords
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Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 51, Issue 1, Pages 373-385
Publisher
Portland Press Ltd.
Online
2023-02-16
DOI
10.1042/bst20220940
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- (2022) Yoshiya Tanaka et al. Nature Reviews Rheumatology
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- (2022) Victoria R. Mingione et al. JOURNAL OF MOLECULAR BIOLOGY
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- (2022) Kevin L. Winthrop et al. Nature Reviews Rheumatology
- Mechanistic Insights Into Co-Administration of Allosteric and Orthosteric Drugs to Overcome Drug-Resistance in T315I BCR-ABL1
- (2022) Hao Zhang et al. Frontiers in Pharmacology
- The protein kinase CK1: Inhibition, activation, and possible allosteric modulation
- (2022) Yashoda Krishna Sunkari et al. Frontiers in Molecular Biosciences
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- (2021) Sebastian Günther et al. SCIENCE
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- (2021) Kevin Freeman-Cook et al. CANCER CELL
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- (2021) Silvio Danese et al. INFLAMMATORY BOWEL DISEASES
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- (2021) Jorge Cortes et al. LANCET
- Current and future status of JAK inhibitors
- (2021) Donal P McLornan et al. LANCET
- GCN2 kinase activation by ATP-competitive kinase inhibitors
- (2021) Colin P. Tang et al. Nature Chemical Biology
- Cooperativity Between Orthosteric Inhibitors and Allosteric Inhibitor 8-Anilino-1-Naphthalene Sulfonic Acid (ANS) in Cyclin-Dependent Kinase 2
- (2020) Erik B. Faber et al. ACS Chemical Biology
- Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms
- (2020) Daniel P. Duarte et al. Nature Communications
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- (2019) Shaoyong Lu et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2019) Ciric To et al. Cancer Discovery
- Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation
- (2019) George M Burslem et al. CANCER RESEARCH
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- (2019) Ryan Moslin et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2019) Maryam Shariati et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
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- (2018) Neel H. Shah et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
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- (2014) P. J. Lupardus et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- Evolution of the eukaryotic protein kinases as dynamic molecular switches
- (2012) S. S. Taylor et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
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- (2009) Tatsuya Okuzumi et al. Nature Chemical Biology
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- (2008) Panagis Filippakopoulos et al. CELL
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