HSPA8 regulates anti-bacterial autophagy through liquid-liquid phase separation

Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells

(2022) Enrico Desideri et al.   Autophagy

Bladder epithelial cell phosphate transporter inhibition protects mice against uropathogenic Escherichia coli infection

(2022) Yu Pang et al.   Cell Reports

K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

(2022) Yi-Ting Wang et al.   Cell Reports

Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization

(2022) Xuan Sun et al.   mBio

Integrated Analysis Reveals S100a8/a9 Regulates Autophagy and Apoptosis through the MAPK and PI3K-AKT Signaling Pathway in the Early Stage of Myocardial Infarction

(2022) Weijue Yi et al.   Cells

Diving into the Evolutionary History of HSC70-Linked Selective Autophagy Pathways: Endosomal Microautophagy and Chaperone-Mediated Autophagy

(2022) Simon Schnebert et al.   Cells

Human heat shock cognate protein (HSC70/HSPA8) interacts with negatively charged phospholipids by a different mechanism than other HSP70s and brings HSP90 into membranes

(2021) Paulo R. Dores-Silva et al.   CELL STRESS & CHAPERONES

An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli

(2021) Chunhui Miao et al.   Nature Communications

NGFR Increases the Chemosensitivity of Colorectal Cancer Cells by Enhancing the Apoptotic and Autophagic Effects of 5-fluorouracil via the Activation of S100A9

(2021) Hao Chen et al.   Frontiers in Oncology

Liquid–Liquid Phase Separation at the Plasma Membrane–Cytosol Interface: Common Players in Adhesion, Motility, and Synaptic Function

(2021) Martina Ramella et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular basis for recognition of Gly/N-degrons by CRL2ZYG11B and CRL2ZER1

(2021) Xiaojie Yan et al.   MOLECULAR CELL

Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia-sensitive platesomes

(2021) Wenhui Tao et al.   Acta Pharmaceutica Sinica B

Drosophila NUAK functions with Starvin/BAG3 in autophagic protein turnover

(2020) David Brooks et al.   PLoS Genetics

Salmonella Interacts With Autophagy to Offense or Defense

(2020) Shu Wu et al.   Frontiers in Microbiology

PRDX2 removal inhibits the cell cycle and autophagy in colorectal cancer cells

(2020) Xiangru Zheng et al.   Aging-US

GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling

(2020) Jinwei Zhu et al.   MOLECULAR CELL

Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease

(2020) Yi Lu et al.   Science Translational Medicine

Hsc70/Stub1 promotes the removal of individual oxidatively stressed peroxisomes

(2020) Bo-Hua Chen et al.   Nature Communications

Sorting nexin 5 mediates virus-induced autophagy and immunity

(2020) Xiaonan Dong et al.   NATURE

A Bacterial Effector Reveals the V-ATPase-ATG16L1 Axis that Initiates Xenophagy

(2019) Yue Xu et al.   CELL

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization

(2018) Shangda Yang et al.   Nature Communications

Phosphoglycerate dehydrogenase inhibition induces p-mTOR-independent autophagy and promotes multilineage differentiation in embryonal carcinoma stem-like cells

(2018) Tanveer Sharif et al.   Cell Death & Disease

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

(2018) Yanjun Li et al.   EMBO JOURNAL

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB

(2017) Jessica Noad et al.   Nature Microbiology

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity

(2016) D.-Q. Xu et al.   EMBO JOURNAL

Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release

(2016) Jennifer N. Rauch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy

(2016) Kateryna Morozova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Classification of Intrinsically Disordered Regions and Proteins

(2014) Robin van der Lee et al.   CHEMICAL REVIEWS

HSPA8/HSC70 chaperone protein

(2013) François Stricher et al.   Autophagy

Endoplasmic Reticulum Protein Quality Control Is Determined by Cooperative Interactions between Hsp/c70 Protein and the CHIP E3 Ligase

(2013) Yoshihiro Matsumura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy

(2011) Congfeng Xu et al.   FASEB JOURNAL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Topology and dynamics of the 10 kDa C-terminal domain of DnaK in solution

(2010) Eric B. Bertelsen et al.   PROTEIN SCIENCE

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells

(2009) Nicolas Page et al.   PLoS One

Heat shock cognate protein 70 contributes to Brucella invasion into trophoblast giant cells that cause infectious abortion

(2008) Kenta Watanabe et al.   BMC MICROBIOLOGY