Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization

Plasminogen activator inhibitor-1 reduces cardiac fibrosis and promotes M2 macrophage polarization in inflammatory cardiomyopathy

(2021) Christian Baumeier et al.   BASIC RESEARCH IN CARDIOLOGY

Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice

(2021) Océane Dufies et al.   Nature Microbiology

Targeting NSD2-mediated SRC-3 liquid–liquid phase separation sensitizes bortezomib treatment in multiple myeloma

(2021) Jing Liu et al.   Nature Communications

Dual transcriptional analysis reveals adaptation of host and pathogen to intracellular survival of Pseudomonas aeruginosa associated with urinary tract infection

(2021) Cristina Penaranda et al.   PLoS Pathogens

MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway

(2021) Xiaoxiao Zhu et al.   Frontiers in Pharmacology

Molecular determinants of disease severity in urinary tract infection

(2021) Ines Ambite et al.   Nature Reviews Urology

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation

(2021) Stefan Reber et al.   NUCLEIC ACIDS RESEARCH

Processive dynamics of the usher assembly platform during uropathogenic Escherichia coli P pilus biogenesis

(2021) Minge Du et al.   Nature Communications

Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation

(2021) He Sun et al.   Nature Communications

The RyfA small RNA regulates oxidative and osmotic stress responses and virulence in uropathogenic Escherichia coli

(2021) Hicham Bessaiah et al.   PLoS Pathogens

Effects of the Escherichia coli Bacterial Toxin Cytotoxic Necrotizing Factor 1 on Different Human and Animal Cells: A Systematic Review

(2021) Francesca Carlini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Spatial proteomics revealed a CX3CL1-dependent crosstalk between the urothelium and relocated macrophages through IL-6 during an acute bacterial infection in the urinary bladder

(2020) Jenny Bottek et al.   Mucosal Immunology

Interleukin 37 Suppresses M1 Macrophage Polarization Through Inhibition of the Notch1 and Nuclear Factor Kappa B Pathways

(2020) Peitao Zhou et al.   Frontiers in Cell and Developmental Biology

Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC

(2020) Yaxiu Guo et al.   FASEB JOURNAL

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

(2020) Zhenying Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates

(2020) Yan G. Zhao et al.   DEVELOPMENTAL CELL

Liquid-Liquid Phase Separation in Neuronal Development and Synaptic Signaling

(2020) Xiandeng Wu et al.   DEVELOPMENTAL CELL

Macrophage Depletion in CCR2−/− Mice Delays Bacterial Clearance and Enhances Neutrophil Infiltration in an Acute Otitis Media Model

(2020) Dong Gu Hur et al.   JOURNAL OF INFECTIOUS DISEASES

Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation

(2020) Chen Wang et al.   MOLECULAR CELL

RNA contributions to the form and function of biomolecular condensates

(2020) Christine Roden et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

(2020) Jason Z. Zhang et al.   CELL

Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

(2020) Guangya Zhu et al.   CELL

Liquid–Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus–Host Interactions

(2020) Stefania Brocca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulatory mechanisms of tau protein fibrillation under the conditions of liquid–liquid phase separation

(2020) Solomiia Boyko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity, Mechanisms, and Significance of Macrophage Plasticity

(2019) Massimo Locati et al.   Annual Review of Pathology-Mechanisms of Disease

Rapid Growth and Metabolism of UropathogenicEscherichia coliin Relation to Urine Composition

(2019) Larry Reitzer et al.   CLINICAL MICROBIOLOGY REVIEWS

Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury

(2019) Changying Wang et al.   Mucosal Immunology

Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection

(2019) Trung H.M. Pham et al.   Cell Host & Microbe

Bladder resident macrophages: Mucosal sentinels

(2018) Livia Lacerda Mariano et al.   CELLULAR IMMUNOLOGY

Bacterial Toxins and Targeted Brain Therapy: New Insights from Cytotoxic Necrotizing Factor 1 (CNF1)

(2018) Elena Tantillo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modular domain swapping among the bacterial cytotoxic necrotizing factor (CNF) family for efficient cargo delivery into mammalian cells

(2018) Elizabeth E. Haywood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysing the Structural Effect of Point Mutations of Cytotoxic Necrotizing Factor 1 (CNF1) on Lu/BCAM Adhesion Glycoprotein Association

(2018) Alexandre de Brevern   Toxins

CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors

(2018) Mengfei Ho et al.   Pathogens and Disease

Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections

(2018) Huan Yang et al.   Frontiers in Immunology

Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis

(2017) Yaxiu Guo et al.   JOURNAL OF PATHOLOGY

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Urinary tract infection: recent insight into the evolutionary arms race between uropathogenic Escherichia coli and our immune system

(2017) Sebastian Schwab et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK–Receptor Interactions

(2017) Ryan Ferrao et al.   Frontiers in Endocrinology

Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

The effects of cytotoxic necrotizing factor 1 expression in the uptake ofEscherichia coliK1 by macrophages and the onset of meningitis in newborn mice

(2016) Alexander C. Chang et al.   Virulence

Endotoxin contamination of apolipoprotein A-I: Effect on macrophage proliferation – A cautionary tale

(2015) Xueting Jin et al.   ATHEROSCLEROSIS

The activating effect of IFN-γ on monocytes/macrophages is regulated by the LIF–trophoblast–IL-10 axis via Stat1 inhibition and Stat3 activation

(2014) Angham Dallagi et al.   Cellular & Molecular Immunology

Macrophage Polarization in Inflammatory Diseases

(2014) Yan-Cun Liu et al.   International Journal of Biological Sciences

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Escherichia coli Cytotoxic Necrotizing Factor 1 (CNF1): Toxin Biology, in Vivo Applications and Therapeutic Potential

(2010) Alessia Fabbri et al.   Toxins

Cleavage of Escherichia coli Cytotoxic Necrotizing Factor 1 Is Required for Full Biologic Activity

(2009) Z. Knust et al.   INFECTION AND IMMUNITY

Macrophage diversity in renal injury and repair

(2008) Sharon D. Ricardo et al.   JOURNAL OF CLINICAL INVESTIGATION

The Rho-activating CNF1 toxin from pathogenic E. coli: A risk factor for human cancer development?

(2008) Sara Travaglione et al.   Infectious Agents and Cancer