Narirutin activates TFEB (transcription factor EB) to protect against Acetaminophen-induced liver injury by targeting PPP3/calcineurin

Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose

(2022) Jephte Y. Akakpo et al.   ARCHIVES OF TOXICOLOGY

Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

(2021) Nga T. Nguyen et al.   ARCHIVES OF TOXICOLOGY

Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development

(2021) Anup Ramachandran et al.   ANTIOXIDANTS & REDOX SIGNALING

Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole

(2021) Jephte Y. Akakpo et al.   ARCHIVES OF TOXICOLOGY

Citrus flavonoids as potential therapeutic agents: A review

(2021) Fiaz Alam et al.   PHYTOTHERAPY RESEARCH

Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway

(2021) Xiliang Du et al.   Acta Pharmaceutica Sinica B

Preventive Effect of Flavonoid Extract from the Peel of Gonggan (Citrus reticulata Blanco Var. Gonggan) on CCl4-Induced Acute Liver Injury in Mice

(2021) Ya Wu et al.   Journal of Inflammation Research

Cyanidin‐3‐O‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice

(2020) Xinwei Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Phenolic composition, antioxidant potential and health benefits of citrus peel

(2020) Balwinder Singh et al.   FOOD RESEARCH INTERNATIONAL

Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury

(2020) Chelsey B. Reed et al.   JOURNAL OF NEUROSCIENCE

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

(2020) Gennaro Napolitano et al.   NATURE

Insight into the Dual inhibitory Mechanism of verbascoside targeting serine/threonine phosphatase Stp1 against Staphylococcus aureus

(2020) Yanan Yang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase

(2019) Jephte Y Akakpo et al.   TOXICOLOGICAL SCIENCES

Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice

(2019) Hua Wang et al.   Redox Biology

Glycycoumarin protects mice against acetaminophen-induced liver injury predominantly via activating sustained autophagy

(2018) Mingzhu Yan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

(2018) JY Akakpo et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

(2018) José A. Martina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced autophagy contributes to protective effects of IL-22 against acetaminophen-induced liver injury

(2018) Ruidong Mo et al.   Theranostics

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

(2016) Sheng-Jie Li et al.   CELL RESEARCH

Removal of acetaminophen protein adducts by autophagy protects against acetaminophen-induced liver injury in mice

(2016) Hong-Min Ni et al.   JOURNAL OF HEPATOLOGY

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy

(2016) Xiaoli Zhang et al.   Nature Communications

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice

(2015) Yong-Hoon Kim et al.   JOURNAL OF HEPATOLOGY

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice

(2014) Zhuofeng Lin et al.   JOURNAL OF HEPATOLOGY

The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris

(2014) J. A. Martina et al.   Science Signaling

Narirutin fraction from citrus peels attenuates alcoholic liver disease in mice

(2013) Ho-Young Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Enzymatic modification enhances the protective activity of citrus flavonoids against alcohol-induced liver disease

(2013) Ho-Young Park et al.   FOOD CHEMISTRY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Activation of autophagy protects against acetaminophen-induced hepatotoxicity

(2011) Hong-Min Ni et al.   HEPATOLOGY

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Ligand docking and binding site analysis with PyMOL and Autodock/Vina

(2010) Daniel Seeliger et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity

(2010) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments

(2009) S. A. Bustin et al.   CLINICAL CHEMISTRY

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Target identification using drug affinity responsive target stability (DARTS)

(2009) B. Lomenick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE