Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway
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Title
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway
Authors
Keywords
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Journal
Acta Pharmaceutica Sinica B
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-12-22
DOI
10.1016/j.apsb.2021.12.012
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- (2020) Huantian Cui et al. Frontiers in Pharmacology
- Insight into the Dual inhibitory Mechanism of verbascoside targeting serine/threonine phosphatase Stp1 against Staphylococcus aureus
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- (2019) Andrea Ballabio et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK/mTOR pathway
- (2018) Chenqu Wu et al. CHEMICO-BIOLOGICAL INTERACTIONS
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- Mechanisms of NAFLD development and therapeutic strategies
- (2018) Scott L. Friedman et al. NATURE MEDICINE
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- (2018) Hao Zhang et al. Autophagy
- Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through PPARα/PGC1α pathway
- (2018) Chao Zhang et al. BRITISH JOURNAL OF PHARMACOLOGY
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- (2017) Ashley M. Thelen et al. TRENDS IN CELL BIOLOGY
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- (2017) Zongkai Mu et al. Cell Discovery
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- (2016) Koichiro Miyagawa et al. AMERICAN JOURNAL OF PATHOLOGY
- TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages
- (2016) Nunzia Pastore et al. Autophagy
- Function of Autophagy in Nonalcoholic Fatty Liver Disease
- (2016) Mark J. Czaja DIGESTIVE DISEASES AND SCIENCES
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- (2016) Ming-Xing Wang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency
- (2016) Benjamin L. Farah et al. JOURNAL OF HEPATOLOGY
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- (2013) Rohit A. Sinha et al. HEPATOLOGY
- Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
- (2013) Jose A. Martina et al. JOURNAL OF CELL BIOLOGY
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- (2008) Y. Sancak et al. SCIENCE
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