Comprehensive in vitro analysis evaluating the variable drug–drug interaction risk of rifampicin compared to rifabutin

Physiology‐based pharmacokinetic modelling and experimental data suggest that rifabutin alters dolutegravir kinetics by both P‐glycoprotein induction and concurrent inhibition

(2023) Dirk Theile et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

How to avoid misinterpretation of dual reporter gene assay data affected by cell damage

(2022) Julie Nilles et al.   ARCHIVES OF TOXICOLOGY

Crystal violet staining is a reliable alternative to bicinchoninic acid assay-based normalization

(2022) Julie Nilles et al.   BIOTECHNIQUES

Time-Resolved Effect of Interferon-Alpha 2a on Activities of Nuclear Factor Kappa B, Pregnane X Receptor and on Drug Disposition Genes

(2021) Dirk Theile et al.   Pharmaceutics

Does the circulating ketoconazole metabolite N-deacetyl ketoconazole contribute to the drug-drug interaction potential of the parent compound?

(2021) Johanna Weiss et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Hepatocytic transcriptional signatures predict comparative drug interaction potential of rifamycin antibiotics

(2020) Shetty Ravi Dyavar et al.   Scientific Reports

Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis

(2019) Dongying Li et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine

(2018) Justin D. Lutz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin

(2018) Justin D. Lutz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Multiple Doses of Rifabutin Reduce Exposure of Doravirine in Healthy Subjects

(2018) Sauzanne G. Khalilieh et al.   JOURNAL OF CLINICAL PHARMACOLOGY

A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions

(2017) Takashi Yoshikado et al.   PHARMACEUTICAL RESEARCH

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

(2016) Petr Pavek   Frontiers in Pharmacology

Extrahepatic metabolism at the body's internal–external interfaces

(2014) Ursula Gundert-Remy et al.   DRUG METABOLISM REVIEWS

Induction of Influx and Efflux Transporters and Cytochrome P450 3A4 in Primary Human Hepatocytes by Rifampin, Rifabutin, and Rifapentine

(2013) Beth Williamson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In-vitro evaluation of chronic alcohol effects on expression of drug-metabolizing and drug-transporting proteins

(2013) Dirk Theile et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Pharmacokinetics and 48 Week Efficacy of Adjusted Dose Indinavir/Ritonavir in Rifampicin-Treated HIV/Tuberculosis-Coinfected Patients: A Pilot Study

(2012) Anchalee Avihingsanon et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells

(2012) Johanna Weiss et al.   BIOCHEMICAL PHARMACOLOGY

Differential modulation of the expression of important drug metabolising enzymes and transporters by endothelin-1 receptor antagonists ambrisentan and bosentan in vitro

(2011) Johanna Weiss et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impact of drug transporters on cellular resistance towards saquinavir and darunavir

(2010) S. K. Konig et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Update on Rifampin and Rifabutin Drug Interactions

(2009) Anne M. Baciewicz et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells

(2009) Daisuke Yamasaki et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Comparison of Two Immortalized Human Cell Lines to Study Nuclear Receptor-Mediated CYP3A4 Induction

(2008) S. Harmsen et al.   DRUG METABOLISM AND DISPOSITION

Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors

(2008) A. Gupta et al.   DRUG METABOLISM AND DISPOSITION

A regulatory viewpoint on transporter-based drug interactions

(2008) L. Zhang et al.   XENOBIOTICA

Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors

(2007) Johanna Weiss et al.   EUROPEAN JOURNAL OF PHARMACOLOGY