Mechanisms of Protein Quality Control in the Endoplasmic Reticulum by a Coordinated Hsp40-Hsp70-Hsp90 System

NudC guides client transfer between the Hsp40/70 and Hsp90 chaperone systems

(2022) Maximilian M. Biebl et al.   MOLECULAR CELL

The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone of Grp94

(2022) Bin Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrostatics Drive the Molecular Chaperone BiP to Preferentially Bind Oligomerized States of a Client Protein

(2022) Erin E. Deans et al.   JOURNAL OF MOLECULAR BIOLOGY

Grp94 Works Upstream of BiP in Protein Remodeling Under Heat Stress

(2022) Yaa S. Amankwah et al.   JOURNAL OF MOLECULAR BIOLOGY

The cytoprotective protein MANF promotes neuronal survival independently from its role as a GRP78 cofactor

(2021) Ave Eesmaa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ER Chaperones BiP and Grp94 Regulate the Formation of Insulin-Like Growth Factor 2 (IGF2) Oligomers

(2021) Yi Jin et al.   JOURNAL OF MOLECULAR BIOLOGY

Network organisation and the dynamics of tubules in the endoplasmic reticulum

(2021) Hannah T. Perkins et al.   Scientific Reports

Endoplasmic reticulum tubules limit the size of misfolded protein condensates

(2021) Smriti Parashar et al.   eLife

Structure of Hsp90–Hsp70–Hop–GR reveals the Hsp90 client-loading mechanism

(2021) Ray Yu-Ruei Wang et al.   NATURE

Structure of Hsp90–p23–GR reveals the Hsp90 client-remodelling mechanism

(2021) Chari M. Noddings et al.   NATURE

Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production

(2020) Yair Argon et al.   Cells

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

(2020) Steffen Preissler et al.   eLife

MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP

(2019) Yahui Yan et al.   Nature Communications

The ER chaperones BiP and Grp94 selectively associate when BiP is in the ADP conformation.

(2019) Ming Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Cycling within the Closed State of Grp94, an Hsp90-Family Chaperone

(2019) Bin Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for client recognition and activity of Hsp40 chaperones

(2019) Yajun Jiang et al.   SCIENCE

Disposing of misfolded ER proteins: A troubled substrate's way out of the ER

(2019) Christina Oikonomou et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mechanistic insights into ER-associated protein degradation

(2018) Xudong Wu et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones

(2018) Roman Kityk et al.   MOLECULAR CELL

Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System

(2018) Tania Morán Luengo et al.   MOLECULAR CELL

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation

(2018) Sang Mi Shim et al.   Science Signaling

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

(2018) Olivier Genest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The endoplasmic reticulum (ER) chaperone BiP is a master regulator of ER functions: Getting by with a little help from ERdj friends

(2018) Kristine Faye R. Pobre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent advances in the structural and mechanistic aspects of Hsp70 molecular chaperones

(2018) Matthias P Mayer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hsp70–Hsp90 Chaperone Cascade in Protein Folding

(2018) Tania Morán Luengo et al.   TRENDS IN CELL BIOLOGY

Bacterial proteostasis balances energy and chaperone utilization efficiently

(2017) Mantu Santra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s

(2017) Jiao Yang et al.   Nature Communications

The flexibility and dynamics of the tubules in the endoplasmic reticulum

(2017) Pantelis Georgiades et al.   Scientific Reports

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site

(2017) John D. Huck et al.   Cell Reports

Allosteric fine-tuning of the conformational equilibrium poises the chaperone BiP for post-translational regulation

(2017) Lukasz Wieteska et al.   eLife

An unexpected role for the yeast nucleotide exchange factor Sil1 as a reductant acting on the molecular chaperone BiP

(2017) Kevin D Siegenthaler et al.   eLife

N-linked glycosylation and homeostasis of the endoplasmic reticulum

(2016) Natalia Cherepanova et al.   CURRENT OPINION IN CELL BIOLOGY

Formation and Reversibility of BiP Protein Cysteine Oxidation Facilitate Cell Survival during and post Oxidative Stress

(2016) Jie Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control

(2016) Julia Behnke et al.   MOLECULAR CELL

The epichaperome is an integrated chaperome network that facilitates tumour survival

(2016) Anna Rodina et al.   NATURE

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

(2016) K. A. Verba et al.   SCIENCE

Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP

(2015) Jiao Yang et al.   STRUCTURE

Hsp90 interaction with clients

(2015) G. Elif Karagöz et al.   TRENDS IN BIOCHEMICAL SCIENCES

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

(2015) Steffen Preissler et al.   eLife

Orchestration of secretory protein folding by ER chaperones

(2013) Tali Gidalevitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Glucose-regulated Protein 94 Triage of Mutant Myocilin through Endoplasmic Reticulum-associated Degradation Subverts a More Efficient Autophagic Clearance Mechanism

(2012) Amirthaa Suntharalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

FoldEco: A Model for Proteostasis in E. coli

(2012) Evan T. Powers et al.   Cell Reports

Structural analysis of the Sil1–Bip complex reveals the mechanism for Sil1 to function as a nucleotide-exchange factor

(2011) Ming Yan et al.   BIOCHEMICAL JOURNAL

A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature

(2011) Matt West et al.   JOURNAL OF CELL BIOLOGY

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

(2011) Moritz Marcinowski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates

(2010) Marta Stankiewicz et al.   FEBS Journal

The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper

(2010) Simon Wilkins et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

BiP Availability Distinguishes States of Homeostasis and Stress in the Endoplasmic Reticulum of Living Cells

(2010) Chun Wei Lai et al.   MOLECULAR BIOLOGY OF THE CELL

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

(2010) Bei Liu et al.   Nature Communications

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones

(2009) Daniel W. Summers et al.   TRENDS IN BIOCHEMICAL SCIENCES

How antibodies fold

(2009) Matthias J. Feige et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP

(2008) Nobuko Hosokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis for Regulation of the Heat Shock Transcription Factor σ32 by the DnaK and DnaJ Chaperones

(2008) Fernanda Rodriguez et al.   MOLECULAR CELL