Glucose-Regulated Protein 94 (GRP94): A Novel Regulator of Insulin-Like Growth Factor Production

COMPARATIVE EFFICACY OF MEDICAL TREATMENT FOR ACROMEGALY: A SYSTEMIC REVIEW AND NETWORK META-ANALYSIS OF INTEGRATED RANDOMIZED TRIALS AND OBSERVATIONAL STUDIES

(2020) Nidan Qiao et al.   Endocrine Practice

The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94 deficient β cells and is overexpressed in type 2 diabetes pancreatic islets

(2020) Muhammad Saad Khilji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective

(2019) Paulo F. Collett-Solberg et al.   Hormone Research in Paediatrics

The insulin-like growth factor-I receptor stimulating activity (IRSA) in health and disease

(2019) Joseph A.M.J.L. Janssen et al.   GROWTH HORMONE & IGF RESEARCH

Structural basis of the activation of type 1 insulin-like growth factor receptor

(2019) Jie Li et al.   Nature Communications

Insulin-like growth factors: actions on the skeleton

(2018) Shoshana Yakar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy

(2018) Markus Jahn et al.   STRUCTURE

The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease

(2018) Abdullah Hoter et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94

(2016) Ephraim A. Ansa-Addo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability

(2016) A. Dauber et al.   EMBO Molecular Medicine

A Human Variant of Glucose-Regulated Protein 94 That Inefficiently Supports IGF Production

(2016) Michal Marzec et al.   ENDOCRINOLOGY

STAT5B deficiency: Impacts on human growth and immunity

(2016) Vivian Hwa   GROWTH HORMONE & IGF RESEARCH

Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency

(2016) Adda Grimberg et al.   Hormone Research in Paediatrics

Reference Values for IGF-I Serum Concentrations: Comparison of Six Immunoassays

(2016) Philippe Chanson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The endocrine manifestations of anorexia nervosa: mechanisms and management

(2016) Melanie Schorr et al.   Nature Reviews Endocrinology

Diagnosis and management of Silver–Russell syndrome: first international consensus statement

(2016) Emma L. Wakeling et al.   Nature Reviews Endocrinology

GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults

(2015) D B Allen et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

GP96 is a GARP chaperone and controls regulatory T cell functions

(2015) Yongliang Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Acromegaly: An Endocrine Society Clinical Practice Guideline

(2014) Laurence Katznelson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Endocrine consequences of anorexia nervosa

(2014) Madhusmita Misra et al.   Lancet Diabetes & Endocrinology

α7 Helix Region of αI Domain Is Crucial for Integrin Binding to Endoplasmic Reticulum Chaperone gp96

(2013) Feng Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway

(2013) B. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production

(2012) Elisabeth R. Barton et al.   FASEB JOURNAL

Overexpression of GRP94 in breast cancer cells resistant to oxidative stress promotes high levels of cancer cell proliferation and migration: Implications for tumor recurrence

(2012) Nicolas Dejeans et al.   FREE RADICAL BIOLOGY AND MEDICINE

Insulin-Like Growth Factor 2 in Development and Disease: A Mini-Review

(2012) Daniel Bergman et al.   GERONTOLOGY

The Molecular Chaperone gp96/GRP94 Interacts with Toll-like Receptors and Integrins via Its C-terminal Hydrophobic Domain

(2012) Shuang Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response

(2012) D. Eletto et al.   JOURNAL OF CELL SCIENCE

Proteomic Plasma Membrane Profiling Reveals an Essential Role for gp96 in the Cell Surface Expression of LDLR Family Members, Including the LDL Receptor and LRP6

(2012) Michael P. Weekes et al.   JOURNAL OF PROTEOME RESEARCH

GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum

(2011) Michal Marzec et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex

(2011) M. Staron et al.   BLOOD

Consensus Statement on the Standardization and Evaluation of Growth Hormone and Insulin-like Growth Factor Assays

(2011) D. R. Clemmons et al.   CLINICAL CHEMISTRY

Accelerating Protein Docking in ZDOCK Using an Advanced 3D Convolution Library

(2011) Brian G. Pierce et al.   PLoS One

Deciphering the Hidden Informational Content of Protein Sequences

(2010) Ming Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone

(2010) Bei Liu et al.   Nature Communications

Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors

(2009) Olga Ostrovsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hsp90 and co-chaperones twist the functions of diverse client proteins

(2009) Abbey Zuehlke et al.   BIOPOLYMERS

gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis

(2009) M. Staron et al.   BLOOD

Contribution of Residue B5 to the Folding and Function of Insulin and IGF-I

(2009) Youhei Sohma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperone Activity of GRP94 Toward Insulin-like Growth Factor II Is Necessary for the Stress Response to Serum Deprivation

(2009) Olga Ostrovsky et al.   MOLECULAR BIOLOGY OF THE CELL

An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells

(2009) Olga Ostrovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Keeping IGF-II under control: Lessons from the IGF-II–IGF2R crystal structure

(2009) James Brown et al.   TRENDS IN BIOCHEMICAL SCIENCES

Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin

(2008) B. Liu et al.   BLOOD

Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism

(2008) Shoshana Yakar et al.   FASEB JOURNAL

The Hsp90 Chaperone Machinery

(2008) Sebastian Karl Wandinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

JAK2, But Not Src Family Kinases, Is Required for STAT, ERK, and Akt Signaling in Response to Growth Hormone in Preadipocytes and Hepatoma Cells

(2008) Hui Jin et al.   MOLECULAR ENDOCRINOLOGY