Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s

A disulfide-bonded DnaK dimer is maintained in an ATP-bound state

(2016) Qingdai Liu et al.   CELL STRESS & CHAPERONES

Function and Chemotypes of Human Hsp70 Chaperones

(2016) Liza Shrestha et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain

(2016) Andrea Gumiero et al.   Nature Communications

A Functional DnaK Dimer Is Essential for the Efficient Interaction with Hsp40 Heat Shock Protein

(2015) Evans Boateng Sarbeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

Substrate-binding domain conformational dynamics mediate Hsp70 allostery

(2015) Anastasia Zhuravleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Close and Allosteric Opening of the Polypeptide-Binding Site in a Human Hsp70 Chaperone BiP

(2015) Jiao Yang et al.   STRUCTURE

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum

(2015) Steffen Preissler et al.   eLife

ERdj3 Is an Endoplasmic Reticulum Degradation Factor for Mutant Glucocerebrosidase Variants Linked to Gaucher’s Disease

(2014) Yun Lei Tan et al.   CHEMISTRY & BIOLOGY

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

(2013) Ruifeng Qi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Interdomain Energetic Tug-of-War Creates the Allosterically Active State in Hsp70 Molecular Chaperones

(2012) Anastasia Zhuravleva et al.   CELL

Hsp70 Protein Complexes as Drug Targets

(2012) Victoria A. Assimon et al.   CURRENT PHARMACEUTICAL DESIGN

Conformational Selection in Substrate Recognition by Hsp70 Chaperones

(2012) Moritz Marcinowski et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and Dynamics of the ATP-Bound Open Conformation of Hsp70 Chaperones

(2012) Roman Kityk et al.   MOLECULAR CELL

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

(2011) Jeffrey L Brodsky et al.   CURRENT OPINION IN CELL BIOLOGY

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Four Hydrophobic Residues on the Hsp70 Inter-Domain Linker Have Two Distinct Roles

(2011) Divya Prasanna Kumar et al.   JOURNAL OF MOLECULAR BIOLOGY

The Phenix software for automated determination of macromolecular structures

(2011) Paul D. Adams et al.   METHODS

Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions

(2011) Moritz Marcinowski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanics of Hsp70 chaperones enables differential interaction with client proteins

(2011) Rainer Schlecht et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Fluorescent, Reagentless Biosensor for ADP Based on Tetramethylrhodamine-Labeled ParM

(2010) Simone Kunzelmann et al.   ACS Chemical Biology

The Conformational Dynamics of the Mitochondrial Hsp70 Chaperone

(2010) Koyeli Mapa et al.   MOLECULAR CELL

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

(2010) Magdalena Wisniewska et al.   PLoS One

Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate

(2009) E. B. Bertelsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life and death of a BiP substrate

(2009) Joel H. Otero et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ERdj3, a Luminal ER DnaJ Homologue, Binds Directly to Unfolded Proteins in the Mammalian ER: Identification of Critical Residues†

(2008) Yi Jin et al.   BIOCHEMISTRY

Crystal Structures of the 70-kDa Heat Shock Proteins in Domain Disjoining Conformation

(2008) Yi-Wei Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols