Mechanism of Activation of the Visual Receptor Rhodopsin

A set of common movements within GPCR-G-protein complexes from variability analysis of cryo-EM datasets

(2021) Jacopo Marino et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1

(2021) Qiuyan Chen et al.   NATURE

Structural Basis of Arrestin Selectivity for Active Phosphorylated G Protein-Coupled Receptors

(2021) Preethi C. Karnam et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin

(2020) Andreyah L. Pope et al.   STRUCTURE

Structural insights into differences in G protein activation by family A and family B GPCRs

(2020) Daniel Hilger et al.   SCIENCE

Many faces of the GPCR-arrestin interaction

(2020) Kiae Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit

(2019) Ching-Ju Tsai et al.   eLife

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

The discovery of the ability of rod photoreceptors to signal single photons

(2018) Edward N. Pugh   JOURNAL OF GENERAL PHYSIOLOGY

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

(2018) Yi-Lynn Liang et al.   NATURE

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

(2018) Yi-Lynn Liang et al.   NATURE

Crystal structure of rhodopsin in complex with a mini-Go sheds light on the principles of G protein selectivity

(2018) Ching-Ju Tsai et al.   Science Advances

Understanding the common themes and diverse roles of the second extracellular loop (ECL2) of the GPCR super-family

(2017) Michael J. Woolley et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structural role of the T94I rhodopsin mutation in congenital stationary night blindness

(2016) Ankita Singhal et al.   EMBO REPORTS

Free backbone carbonyls mediate rhodopsin activation

(2016) Naoki Kimata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation

(2016) Naoki Kimata et al.   Nature Communications

Free backbone carbonyls mediate rhodopsin activation

(2016) Naoki Kimata et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for nucleotide exchange in heterotrimeric G proteins

(2015) R. O. Dror et al.   SCIENCE

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Detecting meaning in RSVP at 13 ms per picture

(2013) Mary C. Potter et al.   Attention Perception & Psychophysics

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

(2013) Ankita Singhal et al.   EMBO REPORTS

Retinitis Pigmentosa Mutants Provide Insight into the Role of the N-terminal Cap in Rhodopsin Folding, Structure, and Function

(2013) Chikwado A. Opefi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lifting the lid on GPCRs: the role of extracellular loops

(2012) M Wheatley et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of channel mutations on the uptake and release of the retinal ligand in opsin

(2012) R. Piechnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit

(2011) N. Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diversity and modularity of G protein-coupled receptor structures

(2011) Vsevolod Katritch et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structure and Activation of the Visual Pigment Rhodopsin

(2010) Steven O. Smith   Annual Review of Biophysics

Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function

(2010) Xavier Deupi et al.   PHYSIOLOGY

Highly conserved tyrosine stabilizes the active state of rhodopsin

(2010) J. A. Goncalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Location of the Retinal Chromophore in the Activated State of Rhodopsin*

(2009) Shivani Ahuja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation

(2009) Shivani Ahuja et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE