Many faces of the GPCR-arrestin interaction

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins

(2020) Hyunook Kang et al.   STRUCTURE

Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies

(2020) Anika Mann et al.   Scientific Reports

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

(2020) Yang Lee et al.   NATURE

Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor

(2020) Ali I. Kaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

(2020) Kyungjin Min et al.   STRUCTURE

Therapeutic Potential of Targeting ß-Arrestin

(2019) Richard A. Bond et al.   Frontiers in Pharmacology

Biased Receptor Signaling in Drug Discovery

(2019) Terry Kenakin   PHARMACOLOGICAL REVIEWS

The structural basis of the arrestin binding to GPCRs

(2019) Vsevolod V. Gurevich et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Structural Mechanism of the Arrestin-3/JNK3 Interaction

(2019) Ji Young Park et al.   STRUCTURE

Plethora of functions packed into 45 kDa arrestins: biological implications and possible therapeutic strategies

(2019) Vsevolod V. Gurevich et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

A complex structure of arrestin-2 bound to a G protein-coupled receptor

(2019) Wanchao Yin et al.   CELL RESEARCH

Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex

(2019) Anthony H. Nguyen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?

(2018) Krishna Sriram et al.   MOLECULAR PHARMACOLOGY

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Arrestin-Dependent Signal Transduction

(2018) Qiuyan Chen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of signalling and biased agonism in G protein-coupled receptors

(2018) Denise Wootten et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

(2018) Louis M. Luttrell et al.   Science Signaling

Arrestins and G proteins in cellular signaling: The coin has two sides

(2018) Vsevolod V. Gurevich et al.   Science Signaling

Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

(2018) Nicole A. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders

(2018) Jaana van Gastel et al.   Frontiers in Pharmacology

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

Novel Structural Insights into GPCR–β-Arrestin Interaction and Signaling

(2017) Ravi Ranjan et al.   TRENDS IN CELL BIOLOGY

Structural basis of arrestin-3 activation and signaling

(2017) Qiuyan Chen et al.   Nature Communications

C-edge loops of arrestin function as a membrane anchor

(2017) Ciara C M. Lally et al.   Nature Communications

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

(2017) Morgan O’Hayre et al.   Science Signaling

Functional competence of a partially engaged GPCR–β-arrestin complex

(2016) Punita Kumari et al.   Nature Communications

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

(2015) Fan Yang et al.   Nature Communications

Structural evidence for the role of polar core residue Arg175 in arrestin activation

(2015) Joachim Granzin et al.   Scientific Reports

Unraveling the molecular architecture of a G protein-coupled receptor/β-arrestin/Erk module complex

(2015) Thomas Bourquard et al.   Scientific Reports

Crystal structure of a common GPCR-binding interface for G protein and arrestin

(2014) Michal Szczepek et al.   Nature Communications

Crystal structure of pre-activated arrestin p44

(2013) Yong Ju Kim et al.   NATURE

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Crystal Structure of p44, a Constitutively Active Splice Variant of Visual Arrestin

(2012) Joachim Granzin et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

(2011) Xuanzhi Zhan et al.   JOURNAL OF MOLECULAR BIOLOGY

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

Beta-arrestins as regulators of signal termination and transduction: How do they determine what to scaffold?

(2010) Kathryn A. DeFea   CELLULAR SIGNALLING

Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

(2009) Dong Soo Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterotrimeric G-proteins: a short history

(2006) Graeme Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY