Structural Basis of Arrestin Selectivity for Active Phosphorylated G Protein-Coupled Receptors

Receptor-Arrestin Interactions: The GPCR Perspective

(2021) Mohammad Seyedabadi et al.   Biomolecules

Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1

(2021) Qiuyan Chen et al.   NATURE

Structural evidence for visual arrestin priming via complexation of phosphoinositols

(2021) Christopher L. Sander et al.   STRUCTURE

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Lysine in the lariat loop of arrestins does not serve as phosphate sensor

(2020) Sergey A. Vishnivetskiy et al.   JOURNAL OF NEUROCHEMISTRY

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

(2020) Yang Lee et al.   NATURE

Biased GPCR signaling: Possible mechanisms and inherent limitations

(2020) Vsevolod V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor

(2020) Ali I. Kaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide

(2020) Kyungjin Min et al.   STRUCTURE

Exploring GPCR-arrestin interfaces with genetically encoded crosslinkers

(2020) Thore Böttke et al.   EMBO REPORTS

How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling

(2020) Naomi R. Latorraca et al.   CELL

The finger loop as an activation sensor in arrestin

(2020) Sergey A. Vishnivetskiy et al.   JOURNAL OF NEUROCHEMISTRY

GRKs as Modulators of Neurotransmitter Receptors

(2020) Eugenia V. Gurevich et al.   Cells

Critical role of the finger loop in arrestin binding to the receptors

(2019) Chen Zheng et al.   PLoS One

A complex structure of arrestin-2 bound to a G protein-coupled receptor

(2019) Wanchao Yin et al.   CELL RESEARCH

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Arrestin-Dependent Signal Transduction

(2018) Qiuyan Chen et al.   TRENDS IN BIOCHEMICAL SCIENCES

GPCRs and Signal Transducers: Interaction Stoichiometry

(2018) Vsevolod V. Gurevich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular mechanism of modulating arrestin conformation by GPCR phosphorylation

(2018) Andrija Sente et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

The Diverse Roles of Arrestin Scaffolds in G Protein–Coupled Receptor Signaling

(2017) Yuri K. Peterson et al.   PHARMACOLOGICAL REVIEWS

Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

(2017) Thomas J. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of arrestin-3 activation and signaling

(2017) Qiuyan Chen et al.   Nature Communications

C-edge loops of arrestin function as a membrane anchor

(2017) Ciara C M. Lally et al.   Nature Communications

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

(2016) Mi-Hye Lee et al.   NATURE

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

(2016) Susanne Nuber et al.   NATURE

Functional map of arrestin binding to phosphorylated opsin, with and without agonist

(2016) Christian Peterhans et al.   Scientific Reports

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes

(2014) Luis E. Gimenez et al.   CELLULAR SIGNALLING

Identification of Receptor Binding-induced Conformational Changes in Non-visual Arrestins

(2014) Ya Zhuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional map of arrestin-1 at single amino acid resolution

(2014) Martin K. Ostermaier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Evolution of phototransduction, vertebrate photoreceptors and retina

(2013) Trevor D. Lamb   PROGRESS IN RETINAL AND EYE RESEARCH

Role of Receptor-attached Phosphates in Binding of Visual and Non-visual Arrestins to G Protein-coupled Receptors

(2012) Luis E. Gimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformation of receptor-bound visual arrestin

(2012) M. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct loops in arrestin differentially regulate ligand binding within the GPCR opsin

(2012) Martha E. Sommer et al.   Nature Communications

A Single Mutation in Arrestin-2 Prevents ERK1/2 Activation by Reducing c-Raf1 Binding

(2011) Sergio Coffa et al.   BIOCHEMISTRY

Few Residues within an Extensive Binding Interface Drive Receptor Interaction and Determine the Specificity of Arrestin Proteins

(2011) Sergey A. Vishnivetskiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

(2011) Xuanzhi Zhan et al.   JOURNAL OF MOLECULAR BIOLOGY

The Effect of Arrestin Conformation on the Recruitment of c-Raf1, MEK1, and ERK1/2 Activation

(2011) Sergio Coffa et al.   PLoS One

The functional cycle of visual arrestins in photoreceptor cells

(2011) Vsevolod V. Gurevich et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling