Ferroptosis and Pyroptosis Co‐Activated Nanomodulator for “Cold” Tumor Immunotherapy and Lung Metastasis Inhibition

A “Valve‐Closing” Starvation Strategy for Amplification of Tumor‐Specific Chemotherapy

(2022) Xianglong Li et al.   Advanced Science

Glutathione Depletion‐Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of “Cold” Tumor

(2022) Zhanwei Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered organosilica hybrid micelles for photothermal‐enhanced starvation cancer therapy

(2022) Xianglong Li et al.   Chemistry-An Asian Journal

GSH‐Responsive Organosilica Hybrid Nanosystem as a Cascade Promoter for Enhanced Starvation and Chemodynamic Therapy

(2022) Huan Wu et al.   Advanced Healthcare Materials

Dual “Unlocking” Strategy to Overcome Inefficient Nanomedicine Delivery and Tumor Hypoxia for Enhanced Photodynamic‐Immunotherapy

(2022) Xianglong Li et al.   Advanced Healthcare Materials

Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy

(2021) Lian‐Hua Fu et al.   ADVANCED MATERIALS

Caspase 3/GSDME-dependent pyroptosis contributes to chemotherapy drug-induced nephrotoxicity

(2021) Xiujin Shen et al.   Cell Death & Disease

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

(2021) Charles L. Evavold et al.   CELL

Doxorubicin suppresses chondrocyte differentiation by stimulating ROS production

(2021) Cheng Wu et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Caspase‐3‐mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway

(2021) Ziwen Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics

(2021) Chenyao Wu et al.   Science Advances

Oligomycin A Induces Apoptosis‐to‐Pyroptosis Switch against Melanoma with Sensitized Immunotherapy

(2021) Liying Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Construction polyprodrugs by click-reactions and metal-coordination: pH-responsive release for magnetic resonance imaging guided chemotherapy

(2021) Daquan Wang et al.   CHEMICAL ENGINEERING JOURNAL

Superstable and Large-Scalable Organosilica-Micellar Hybrid Nanosystem via a Confined Gelation Strategy for Ultrahigh-Dosage Chemotherapy

(2021) Dechao Niu et al.   NANO LETTERS

Top 10 Challenges in Cancer Immunotherapy

(2020) Priti S. Hegde et al.   IMMUNITY

Doxorubicin Induces Endotheliotoxicity and Mitochondrial Dysfunction via ROS/eNOS/NO Pathway

(2020) Huan He et al.   Frontiers in Pharmacology

Tumor‐Specific Chemotherapy by Nanomedicine‐Enabled Differential Stress Sensitization

(2020) Bowen Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11)

(2020) Itsuki Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

Cold atmospheric plasma induces GSDME-dependent pyroptotic signaling pathway via ROS generation in tumor cells

(2020) Xiaorui Yang et al.   Cell Death & Disease

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

(2020) Dan Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Doxorubicin induces prostate cancer drug resistance by upregulation of ABCG4 through GSH depletion and CREB activation: Relevance of statins in chemosensitization

(2019) Sreevidya Mallappa et al.   MOLECULAR CARCINOGENESIS

Engineering Magnetosomes for Ferroptosis/Immunomodulation Synergism in Cancer

(2019) Fan Zhang et al.   ACS Nano

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Synthesis of Copper Peroxide Nanodots for H2O2 Self-Supplying Chemodynamic Therapy

(2019) Li-Sen Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Induction of Pyroptosis and Its Implications in Cancer Management

(2019) Yan-Yang Wang et al.   Frontiers in Oncology

Gradient Redox-Responsive and Two-Stage Rocket-Mimetic Drug Delivery System for Improved Tumor Accumulation and Safe Chemotherapy

(2019) Xiaobo Jia et al.   NANO LETTERS

Disulfide-Bridged Organosilica Frameworks: Designed, Synthesis, Redox-Triggered Biodegradation, and Nanobiomedical Applications

(2018) Xin Du et al.   ADVANCED FUNCTIONAL MATERIALS

Dual Intratumoral Redox/Enzyme-Responsive NO-Releasing Nanomedicine for the Specific, High-Efficacy, and Low-Toxic Cancer Therapy

(2018) Xiaobo Jia et al.   ADVANCED MATERIALS

Lipid Peroxidation Adds Fuel to Pyr(optosis)

(2018) Ashley J. Russo et al.   Cell Host & Microbe

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

(2018) Bo Zhou et al.   CELL RESEARCH

The available intravenous iron formulations: History, efficacy, and toxicology

(2017) Michael Auerbach et al.   Hemodialysis International

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Morphology-Tailoring of a Red AIEgen from Microsized Rods to Nanospheres for Tumor-Targeted Bioimaging

(2016) Yongsheng Li et al.   ADVANCED MATERIALS

Reports to FDA of fatal anaphylaxis associated with intravenous iron products

(2016) Lynda McCulley et al.   AMERICAN JOURNAL OF HEMATOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Cyclo(RGD)-Decorated Reduction-Responsive Nanogels Mediate Targeted Chemotherapy of Integrin Overexpressing Human Glioblastoma In Vivo

(2016) Wei Chen et al.   Small

Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmoc nanocarrier for combination cancer chemotherapy

(2015) Peng Zhang et al.   BIOMATERIALS

The Journey from Discoveries in Fundamental Immunology to Cancer Immunotherapy

(2015) Jacques F.A.P. Miller et al.   CANCER CELL

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

System xc- cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS

(2011) Richard J Bridges et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Mechanisms regulating cytochrome c release in pancreatic mitochondria

(2008) I V Odinokova et al.   GUT