Article
Medicine, Research & Experimental
George Hindy, Daniel J. Tyrrell, Alexi Vasbinder, Changli Wei, Feriel Presswalla, Hui Wang, Pennelope K. Blakely, Ayse Bilge Ozel, Sarah E. Graham, Grace H. Holton, Joseph Dowsett, Akl C. Fahed, Kingsley-Michael Amadi, Grace K. Erne, Annika Tekumulla, Anis Ismail, Christopher Launius, Nona Sotoodehnia, James S. Pankow, Lise Wegner Thorner, Christian Erikstrup, Ole Birger Pedersen, Karina Banasik, Soren Brunak, Henrik Ullum, Jesper Eugen-Olsen, Sisse Rye Ostrowski, Mary E. Haas, Jonas B. Nielsen, Luca A. Lotta, Gunnar Engstrom, Olle Melander, Marju Orho-Melander, Lili Zhao, Venkatesh L. Murthy, David J. Pinsky, Cristen J. Willer, Susan R. Heckbert, Jochen Reiser, Daniel R. Goldstein, Karl C. Desch, Salim S. Hayek
Summary: The study using epidemiologic, genetic, and experimental approaches found that suPAR is a pathogenic factor for atherosclerosis, with its levels strongly associated with cardiovascular outcomes and predictive of coronary artery calcification. The missense variant rs4760 in the PLAUR gene leads to higher suPAR levels, and Mendelian randomization analysis confirms a causal relationship between genetically predicted suPAR levels and atherosclerotic phenotypes. In experimental models, increased suPAR levels modulate monocyte function to promote atherosclerosis.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Immunology
Mariska T. Meijer, Alex F. de Vos, Brendon P. Scicluna, Joris J. Roelofs, Cherine Abou Faycal, Gertraud Orend, Fabrice Uhel, Tom van der Poll
Summary: While TNC plays a role in shaping the immune response during lipopolysaccharide-induced inflammation, its role may be superseded by other factors during pneumosepsis caused by a common gram-negative pathogen.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Qingwen Meng, Huajiang Liu, Jinteng Liu, Yangyang Pang, Qibing Liu
Summary: Cardiovascular disease is a leading cause of death worldwide, and atherosclerosis is the pathological basis of this disease. Recent studies have shown that immune responses induced by certain antigens can alleviate atherosclerosis. Therefore, immunotherapy is expected to be a new preventive and curative measure for atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Courtney D. Thompson, Jessica L. Bradshaw, Wesley S. Miller, Ana G. Jop Vidal, Jorge E. Vidal, Jason W. Rosch, Larry S. McDaniel, Lance E. Keller
Summary: Streptococcus pneumoniae can cause various diseases, but the emergence of nonencapsulated strains poses challenges to vaccination. The AliC and AliD proteins regulate gene expression in pneumococcus, protecting it from complement-mediated clearance by reducing CRP binding.
Review
Cell Biology
Arailym Aronova, Federica Tosato, Nawraa Naser, Yaw Asare
Summary: Innate immune pathways play a crucial role in the development of atherosclerosis and targeting these pathways may effectively reduce the risk of cardiovascular disease. Understanding the interplay between these pathways and the long-term reprogramming of immune cells is essential for the development of targeted therapeutic interventions.
Article
Multidisciplinary Sciences
Jan-Quinten Mol, Julia van Tuijl, Siroon Bekkering, Charlotte D. C. C. van der Heijden, Sander A. J. Damen, Benjamin C. Cossins, Liesbeth van Emst, Tim M. Nielen, Laura Rodwell, Yang Li, Gheorghe A. M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi
Summary: An increasing number of patients develop non-traditional risk factor-induced myocardial infarction, and this study investigated the role of trained immunity in these patients. It was found that monocytes from patients with myocardial infarction had increased cytokine production capacity, particularly interleukin-10, which was associated with specific histone marks. Considering the lack of intervenable risk factors, trained immunity could be a promising target for future therapy.
Review
Cell Biology
Xuanzhi Zhu, Hanyao Huang, Lei Zhao
Summary: Atherosclerosis is a chronic artery disease, and periodontitis is a risk factor for it. There is a molecular pathological mechanism connecting the two conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Cameron Stotts, Vicente F. Corrales-Medina, Katey J. Rayner
Summary: Pneumonia is inflammation in the lungs that is usually caused by an infection. Severe illness is often seen in vulnerable populations such as children, older adults, and those with preexisting health conditions. The inflammatory response during pneumonia appears to play a central role in the development of adverse cardiac events, such as myocardial infarction. Understanding the cross talk between the lungs and the heart during and after pneumonia is crucial for developing therapeutics to prevent pneumonia-associated cardiovascular events.
CIRCULATION RESEARCH
(2023)
Review
Hematology
Daniela Flores-Gomez, Siroon Bekkering, Mihai G. Netea, Niels P. Riksen
Summary: Atherosclerosis is characterized by persistent inflammation in the arterial wall, where trained immunity of the innate immune system may play a crucial role in its pathophysiology. This mechanism offers exciting novel pharmacological targets for the prevention or treatment of cardiovascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Genetics & Heredity
Sahar Eshghjoo, Da Mi Kim, Arul Jayaraman, Yuxiang Sun, Robert C. Alaniz
Summary: This article discusses the different roles and metabolic pathways of pro-inflammatory and anti-inflammatory macrophages in atherosclerosis, emphasizing the importance of the polarization state of Macs for the progression and stability of atherosclerotic plaques.
Article
Microbiology
Stefania Dentice Maidana, Yoshiya Imamura, Mariano Elean, Leonardo Albarracin, Keita Nishiyama, Yoshihito Suda, Shoichiro Kurata, Maria Angela Jure, Haruki Kitazawa, Julio Villena
Summary: Orally administered Lacticaseibacillus rhamnosus CRL1505 enhances respiratory immunity, providing protection against respiratory viruses and Streptococcus pneumoniae. However, its effectiveness against Gram-negative bacterial infections has not been evaluated. This study aimed to assess whether Lcb. rhamnosus CRL1505 could beneficially regulate the respiratory innate immune response and improve resistance to hypermucoviscous KPC-2-producing Klebsiella pneumoniae of the sequence type 25 (ST25).
Review
Immunology
Caroline M. Weight, Simon P. Jochems, Hugh Adler, Daniela M. Ferreira, Jeremy S. Brown, Robert S. Heyderman
Summary: Nasopharyngeal carriage of Streptococcus pneumoniae is common in humans, especially in older individuals. Pneumococcal conjugate vaccines have had some success in protecting young children and indirectly older people through herd immunity, but serotype replacement is still a concern. Older individuals often experience chronic inflammation, known as 'Inflammageing', which may increase mortality risk and affect the outcome of pneumococcal infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sahar Eshghjoo, Arul Jayaraman, Yuxiang Sun, Robert C. Alaniz
Summary: Microbiota-derived metabolites such as tryptophan-derived compounds and trimethylamine-N-oxide play crucial roles in the development of atherosclerosis. Microbiota-induced effects on innate immunity in response to atherogenic stimuli are significant factors in the progression of atherosclerosis.
Article
Immunology
Moon H. Nahm, Jigui Yu, Juan J. Calix, Feroze Ganaie
Summary: Reports conflict on which lectin-microbial ligand interactions trigger a protective response from the lectin pathway (LP) of complement. In this study, researchers demonstrate the binding of human lectin ficolin-2 to the capsule polysaccharide of Streptococcus pneumoniae serotype 11A, which leads to complement deposition and phagocytosis of the bacteria. The study also suggests that the gene wcjE plays a crucial role in ficolin-2's ligand expression and bacterial killing. The findings highlight the importance of glycopolymer-specific evaluation of LP's impact.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Immunology
Xinxin Wang, Yuping Lai
Summary: In this study, the authors investigate the mechanism by which pattern recognition receptors NOD1 and NOD2 sense bacterial muropeptides to induce inflammation in keratinocytes. They demonstrate that solute carrier 46A2 (SLC46A2) transports DAP-muropeptides into the cytosol, leading to NOD1 activation and subsequent skin inflammation during psoriasis.
Article
Chemistry, Applied
Michela Terlizzi, Chiara Colarusso, Umberto Di Maio, Aldo Pinto, Rosalinda Sorrentino
Summary: The study showed that NAXX has strong and long-lasting bacteriostatic activity, which is related to its antioxidant properties. It is identified as an innovative medicinal plant-derived strategy for managing oxidative stress- and microbial-based diseases.
NATURAL PRODUCT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Janet L. Markman, Rebecca A. Porritt, Daiko Wakita, Malcolm E. Lane, Daisy Martinon, Magali Noval Rivas, Michael Luu, Edwin M. Posadas, Timothy R. Crother, Moshe Arditi
NATURE COMMUNICATIONS
(2020)
Editorial Material
Medicine, General & Internal
Shuang Chen, Timothy R. Crother
Article
Immunology
Gantsetseg Tumurkhuu, Shuang Chen, Erica N. Montano, Duygu Ercan Laguna, Gabriela De los Santos, Jeong Min Yu, Malcolm Lane, Michifumi Yamashita, Janet L. Markman, Luz P. Blanco, Mariana J. Kaplan, Kenichi Shimada, Timothy R. Crother, Mariko Ishimori, Daniel J. Wallace, Caroline A. Jefferies, Moshe Arditi
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Jargalsaikhan Dagvadorj, Karolina Mikulska-Ruminska, Gantsetseg Tumurkhuu, Rojo A. Ratsimandresy, Jessica Carriere, Allen M. Andres, Stefanie Marek-Iannucci, Yang Song, Shuang Chen, Malcolm Lane, Andrea Dorfleutner, Roberta A. Gottlieb, Christian Stehlik, Suzanne Cassel, Fayyaz S. Sutterwala, Ivet Bahar, Timothy R. Crother, Moshe Arditi
Summary: The balance between NLRP3 inflammasome activation and mitophagy is crucial for cellular homeostasis, with IL-1 alpha playing a key role in regulating this balance. IL-1 alpha deficiency can lead to altered cellular functions and health by affecting mitochondrial damage and NLRP3 inflammasome activation. The interaction between IL-1 alpha and mitochondrial cardiolipin disrupts mitophagy and enhances NLRP3 inflammasome activation, highlighting the importance of this regulatory mechanism in cellular health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
Rebecca A. Porritt, David Zemmour, Masanori Abe, Youngho Lee, Meena Narayanan, Thacyana T. Carvalho, Angela C. Gomez, Daisy Martinon, Chintda Santiskulvong, Michael C. Fishbein, Shuang Chen, Timothy R. Crother, Kenichi Shimada, Moshe Arditi, Magali Noval Rivas
Summary: This study reveals the cellular landscape of inflamed vascular tissues in a murine model of KD vasculitis, showing that monocytes, macrophages, and dendritic cells are main sources of IL-1 beta, while fibroblasts and vascular smooth muscle cells express high levels of IL-1 receptor.
CIRCULATION RESEARCH
(2021)
Article
Immunology
Hongxu Xian, Yuan Liu, Alexandra Rundberg Nilsson, Raphaella Gatchalian, Timothy R. Crother, Warren G. Tourtellotte, Yi Zhang, German R. Aleman-Muench, Gavin Lewis, Weixuan Chen, Sarah Kang, Melissa Luevanos, Dorit Trudler, Stuart A. Lipton, Pejman Soroosh, John Teijaro, Juan Carlos de la Torre, Moshe Arditi, Michael Karin, Elsa Sanchez-Lopez
Summary: The study found that metformin can attenuate COVID-19-induced ARDS by inhibiting NLRP3 inflammasome activation, IL-1 beta and IL-6 secretion, and by blocking ATP and mtDNA synthesis.
Article
Medicine, Research & Experimental
Stefanie Marek-Iannucci, Asli B. Ozdemir, Debbie Moreira, Angela C. Gomez, Malcolm Lane, Rebecca A. Porritt, Youngho Lee, Kenichi Shimada, Masanori Abe, Aleksandr Stotland, David Zemmour, Sarah Parker, Elsa Sanchez-Lopez, Jennifer Van Eyk, Roberta A. Gottlieb, Michael C. Fishbein, Michael Karin, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
Summary: Kawasaki disease is a leading cause of acquired heart disease in children, with impaired autophagy/mitophagy and ROS contributing to cardiovascular lesions. Enhancing autophagic flux can reduce lesions, while autophagy blockade increases inflammation, demonstrating the potential of targeting this pathway in treatment.
Article
Immunology
Chiara Colarusso, Michela Terlizzi, Anna Falanga, Georgious Stathopoulos, Luigi De Lucia, Phillip M. Hansbro, Aldo Pinto, Rosalinda Sorrentino
Summary: This study demonstrates that AIM2 is involved in lung carcinogenesis and is associated with an immunosuppressive microenvironment. Upregulation of AIM2 is correlated with an inflammasome profile in non-smoker and smoker LUAD patients, while the correlation is weaker in former smokers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Asli E. Atici, Timothy R. Crother, Magali Noval Rivas
Summary: Cardiovascular diseases are a leading cause of death worldwide, and optimal mitochondrial function is crucial for the cardiovascular system. Mitochondrial quality control ensures the clearance of dysfunctional mitochondria and preserves mitochondrial homeostasis, playing a role in cell survival and adaptation to environmental stress.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Meeting Abstract
Immunology
Prasant K. Jena, Daiko Wakita, Angela C. Gomez, Thacyana T. Carvalho, Meena Narayanan, Youngho Lee, Patrice D. Cani, Willem M. de Vos, Suzanne Devkota, David M. Underhill, Shuang Chen, Kenichi Shimada, Timothy R. Crother, Moshe Arditi, Magali Noval Rivas
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Rebecca A. Porritt, David Zemmour, Masanori Abe, Shuang Chen, Timothy R. Crother, Kenichi Shimada, Moshe Arditi, Magali Noval Rivas
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Stefanie Marek-Iannucci, Angela Gomez, Debbie Moreira, Malcolm Lane, Rebecca Porritt, Youngho Lee, Kenichi Shimada, Timothy R. Crother, Magali Noval Rivas, Moshe Arditi
Article
Biochemistry & Molecular Biology
Michela Terlizzi, Chiara Colarusso, Umberto Di Maio, Antonino Bagnulo, Aldo Pinto, Rosalinda Sorrentino
BIOSCIENCE REPORTS
(2020)
Article
Oncology
Michela Terlizzi, Chiara Colarusso, Ilaria De Rosa, Pasquale Somma, Carlo Curcio, Rita P. Aquino, Luigi Panico, Rosario Salvi, Federica Zito Marino, Gerardo Botti, Aldo Pinto, Rosalinda Sorrentino
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2020)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)