NLRP3 Inflammasome Mediates Immune-Stromal Interactions in Vasculitis

Interleukin-1 Beta–Mediated Sex Differences in Kawasaki Disease Vasculitis Development and Response to Treatment

(2020) Rebecca A. Porritt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Kawasaki disease: pathophysiology and insights from mouse models

(2020) Magali Noval Rivas et al.   Nature Reviews Rheumatology

Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage

(2019) Dvir Aran et al.   NATURE IMMUNOLOGY

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data

(2019) Samuel L. Wolock et al.   Cell Systems

Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation

(2019) Ploingarm Petsophonsakul et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation

(2019) Magali Noval Rivas et al.   IMMUNITY

The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction

(2019) Rifeng Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

(2019) Lieselotte Vande Walle et al.   PLOS BIOLOGY

Crucial role of NLRP3 inflammasome in a murine model of Kawasaki disease

(2019) Fumiya Anzai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm

(2018) Marie-Paule Guillaume et al.   CARDIOLOGY IN THE YOUNG

Severe Late-Onset Kawasaki Disease Successfully Treated With Anakinra

(2018) Gauthier Blonz et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Bias, robustness and scalability in single-cell differential expression analysis

(2018) Charlotte Soneson et al.   NATURE METHODS

Whole blood transcriptional profiles as a prognostic tool in complete and incomplete Kawasaki Disease

(2018) Preeti Jaggi et al.   PLoS One

MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

(2018) Agampodi Promoda Perera et al.   Scientific Reports

Kawasaki Disease Outcomes and Response to Therapy in a Multiethnic Community: A 10-Year Experience

(2018) Shannon M. Skochko et al.   JOURNAL OF PEDIATRICS

Diagnosis of Kawasaki Disease Using a Minimal Whole-Blood Gene Expression Signature

(2018) Victoria J. Wright et al.   JAMA Pediatrics

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Interleukin-18: Biological properties and role in disease pathogenesis

(2017) Gilles Kaplanski   IMMUNOLOGICAL REVIEWS

Histopathological aspects of cardiovascular lesions in Kawasaki disease

(2017) Kei Takahashi et al.   International Journal of Rheumatic Diseases

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

(2017) Martina Molgora et al.   NATURE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD8+ T Cells Contribute to the Development of Coronary Arteritis in theLactobacillus caseiCell Wall Extract-Induced Murine Model of Kawasaki Disease

(2017) Magali Noval Rivas et al.   Arthritis & Rheumatology

Review: Found in Translation: International Initiatives Pursuing Interleukin-1 Blockade for Treatment of Acute Kawasaki Disease

(2017) Jane C. Burns et al.   Arthritis & Rheumatology

Role of Interleukin-1 Signaling in a Mouse Model of Kawasaki Disease–Associated Abdominal Aortic AneurysmSignificance

(2016) Daiko Wakita et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Rationale and study design for a phase I/IIa trial of anakinra in children with Kawasaki disease and early coronary artery abnormalities (the ANAKID trial)

(2016) Adriana H. Tremoulet et al.   Contemporary Clinical Trials

Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease

(2016) Martin Prince Alphonse et al.   JOURNAL OF IMMUNOLOGY

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

(2016) P. L. Stahl et al.   SCIENCE

IL-1 Signaling Is Critically Required in Stromal Cells in Kawasaki Disease Vasculitis Mouse ModelSignificance

(2015) Youngho Lee et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The immunomodulatory effects of intravenous immunoglobulin therapy in Kawasaki disease

(2015) Jane C Burns et al.   Expert Review of Clinical Immunology

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Epidemiology of Immunoglobulin Resistant Kawasaki Disease: Results from a Large, National Database

(2014) Brady S. Moffett et al.   PEDIATRIC CARDIOLOGY

Single-Nucleotide Polymorphism rs7251246 in ITPKC Is Associated with Susceptibility and Coronary Artery Lesions in Kawasaki Disease

(2014) Ho-Chang Kuo et al.   PLoS One

Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease

(2014) Long Truong Hoang et al.   Genome Medicine

Interleukin-1β Is Crucial for the Induction of Coronary Artery Inflammation in a Mouse Model of Kawasaki Disease

(2012) Youngho Lee et al.   CIRCULATION

Interleukin-1β modulates smooth muscle cell phenotype to a distinct inflammatory state relative to PDGF-DD via NF-κB-dependent mechanisms

(2012) Matthew R. Alexander et al.   PHYSIOLOGICAL GENOMICS

Three Linked Vasculopathic Processes Characterize Kawasaki Disease: A Light and Transmission Electron Microscopic Study

(2012) Jan Marc Orenstein et al.   PLoS One

Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice

(2011) Matthew R. Alexander et al.   JOURNAL OF CLINICAL INVESTIGATION

IL-1B Polymorphism in Association With Initial Intravenous Immunoglobulin Treatment Failure in Taiwanese Children With Kawasaki Disease

(2010) Ken-Pen Weng et al.   CIRCULATION JOURNAL

Transcript abundance patterns in Kawasaki disease patients with intravenous immunoglobulin resistance

(2010) Wen Fury et al.   HUMAN IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology