Factors controlling permeability of the blood–brain barrier

Soluble VCAM-1 impairs human brain endothelial barrier integrity via integrin α-4-transduced outside-in signalling

(2015) Axel Haarmann et al.   ACTA NEUROPATHOLOGICA

Hydrogen improves neurological function through attenuation of blood–brain barrier disruption in spontaneously hypertensive stroke-prone rats

(2015) Satoru Takeuchi et al.   BMC NEUROSCIENCE

miR-21 alleviates secondary blood–brain barrier damage after traumatic brain injury in rats

(2015) Xintong Ge et al.   BRAIN RESEARCH

Ang-(1–7) exerts protective role in blood–brain barrier damage by the balance of TIMP-1/MMP-9

(2015) Jitao Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

TGF-β1 prevents blood–brain barrier damage and hemorrhagic transformation after thrombolysis in rats

(2015) Yingyuan Cai et al.   EXPERIMENTAL NEUROLOGY

Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats

(2015) Xiaohuan Gu et al.   EXPERIMENTAL NEUROLOGY

Roles of the Cyclooxygenase 2 Matrix Metalloproteinase 1 Pathway in Brain Metastasis of Breast Cancer

(2015) Kerui Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

Hydrogen Sulfide Inhalation Decreases Early Blood—Brain Barrier Permeability and Brain Edema Induced by Cardiac Arrest and Resuscitation

(2015) Yingjie Geng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Aβ1-42oligomer-induced leakage in anin vitroblood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins

(2015) Wenbin Wan et al.   JOURNAL OF NEUROCHEMISTRY

Attenuation of acute stroke injury in rat brain by minocycline promotes blood–brain barrier remodeling and alternative microglia/macrophage activation during recovery

(2015) Yirong Yang et al.   Journal of Neuroinflammation

Peroxynitrite decomposition catalyst prevents matrix metalloproteinase-9 activation and neurovascular injury after hemoglobin injection into the caudate nucleus of rats

(2015) R. Ding et al.   NEUROSCIENCE

Isoflurane anesthesia results in reversible ultrastructure and occludin tight junction protein expression changes in hippocampal blood–brain barrier in aged rats

(2015) Yiyun Cao et al.   NEUROSCIENCE LETTERS

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Pericytes Contribute to the Disruption of the Cerebral Endothelial Barrier via Increasing VEGF Expression: Implications for Stroke

(2015) Ying Bai et al.   PLoS One

Bexarotene Reduces Blood-Brain Barrier Permeability in Cerebral Ischemia-Reperfusion Injured Rats

(2015) Lu Xu et al.   PLoS One

Isoflurane inhibits occludin expression via up-regulation of hypoxia-inducible factor 1α

(2014) Jingyu Zhao et al.   BRAIN RESEARCH

The heparan sulfate proteoglycan agrin contributes to barrier properties of mouse brain endothelial cells by stabilizing adherens junctions

(2014) Esther Steiner et al.   CELL AND TISSUE RESEARCH

Nanomedicine and its Application in Treatment of Microglia-mediated Neuroinflammation

(2014) N. Baby et al.   CURRENT MEDICINAL CHEMISTRY

Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking  V 8-TGF  signaling in the brain

(2014) T. D. Arnold et al.   DEVELOPMENT

Activation of AMPK attenuates lipopolysaccharide-impaired integrity and function of blood–brain barrier in human brain microvascular endothelial cells

(2014) Zhihong Zhao et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

MicroRNA-155 negatively affects blood–brain barrier function during neuroinflammation

(2014) Miguel Alejandro Lopez-Ramirez et al.   FASEB JOURNAL

Disruption of the blood-brain barrier in parkinson's disease: curse or route to a cure?

(2014) Heyne Lee   Frontiers in Bioscience-Landmark

Transcriptional profiling reveals that C5a alters microRNA in brain endothelial cells

(2014) Michael T. Eadon et al.   IMMUNOLOGY

Platelet Endothelial Cell Adhesion Molecule-1, a Putative Receptor for the Adhesion of Streptococcus pneumoniae to the Vascular Endothelium of the Blood-Brain Barrier

(2014) Federico Iovino et al.   INFECTION AND IMMUNITY

Role of MicroRNA29b in Blood–Brain Barrier Dysfunction during Hyperhomocysteinemia: An Epigenetic Mechanism

(2014) Anuradha Kalani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rapid Remodeling of Tight Junctions during Paracellular Diapedesis in a Human Model of the Blood–Brain Barrier

(2014) Ryan C. Winger et al.   JOURNAL OF IMMUNOLOGY

Resveratrol Attenuates the Blood-Brain Barrier Dysfunction by Regulation of the MMP-9/TIMP-1 Balance after Cerebral Ischemia Reperfusion in Rats

(2014) Haidong Wei et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Poloxamer-188 Can Attenuate Blood–Brain Barrier Damage to Exert Neuroprotective Effect in Mice Intracerebral Hemorrhage Model

(2014) Tao Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Rate and extent of leakage of a magnetic resonance contrast agent tend to be lower under isoflurane anesthesia in comparison to halothane in a rat model of embolic stroke

(2014) Francisco J. Bezerra et al.   NEUROLOGICAL RESEARCH

Current preclinical studies on neuroinflammation and changes in blood–brain barrier integrity by MDMA and methamphetamine

(2014) Esther O'Shea et al.   NEUROPHARMACOLOGY

Glial Cell Ceruloplasmin and Hepcidin Differentially Regulate Iron Efflux from Brain Microvascular Endothelial Cells

(2014) Ryan C. McCarthy et al.   PLoS One

Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight Junctions

(2014) Keith D. Rochfort et al.   PLoS One

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

(2014) Yue Wang et al.   PLoS One

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Effect of Simvastatin on MMPs and TIMPs in Human Brain Endothelial Cells and Experimental Stroke

(2014) Björn Reuter et al.   Translational Stroke Research

Barrier mechanisms in neonatal stroke

(2014) Ingrid Kratzer et al.   Frontiers in Neuroscience

Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells

(2014) Wang-Xia Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

MiR-21 involve in ERK-mediated upregulation of MMP9 in the rat hippocampus following cerebral ischemia

(2013) XiaHeng Deng et al.   BRAIN RESEARCH BULLETIN

Cell-specific blood-brain barrier regulation in health and disease: a focus on hypoxia

(2013) S Engelhardt et al.   BRITISH JOURNAL OF PHARMACOLOGY

Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast

(2013) P.M. Abdul-Muneer et al.   FREE RADICAL BIOLOGY AND MEDICINE

The potential mechanisms of Aβ-receptor for advanced glycation end-products interaction disrupting tight junctions of the blood-brain barrier in Alzheimer's disease

(2013) Wenbin Wan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

(2013) A. Reijerkerk et al.   JOURNAL OF NEUROSCIENCE

MMP-3 Contributes to Nigrostriatal Dopaminergic Neuronal Loss, BBB Damage, and Neuroinflammation in an MPTP Mouse Model of Parkinson’s Disease

(2013) Young Cheul Chung et al.   MEDIATORS OF INFLAMMATION

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications

(2013) E. Cristante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired blood–brain/spinal cord barrier in ALS patients

(2012) Svitlana Garbuzova-Davis et al.   BRAIN RESEARCH

NADPH oxidases as therapeutic targets in ischemic stroke

(2012) Timo Kahles et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Matrix metalloproteinase (MMP)-2 gene polymorphisms affect circulating MMP-2 levels in patients with migraine with aura

(2012) Flavia M. Gonçalves et al.   GENE

Neurological Diseases in Relation to the Blood–Brain Barrier

(2012) Gary A Rosenberg   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Role of Caspases in Cytokine-Induced Barrier Breakdown in Human Brain Endothelial Cells

(2012) M. A. Lopez-Ramirez et al.   JOURNAL OF IMMUNOLOGY

Matrix Metalloproteinase-2-Mediated Occludin Degradation and Caveolin-1-Mediated Claudin-5 Redistribution Contribute to Blood-Brain Barrier Damage in Early Ischemic Stroke Stage

(2012) J. Liu et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation: A Common Pathway in CNS Diseases as Mediated at the Blood-Brain Barrier

(2012) Michelle A. Erickson et al.   NEUROIMMUNOMODULATION

Isoflurane Induces Endothelial Apoptosis of the Post-Hypoxic Blood-Brain Barrier in a Transdifferentiated Human Umbilical Vein Edothelial Cell Model

(2012) Michael S. Dittmar et al.   PLoS One

Volatile Anesthetics Influence Blood-Brain Barrier Integrity by Modulation of Tight Junction Protein Expression in Traumatic Brain Injury

(2012) Serge C. Thal et al.   PLoS One

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Viral disruption of the blood–brain barrier

(2012) Katherine R. Spindler et al.   TRENDS IN MICROBIOLOGY

Claudin-1 induced sealing of blood–brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis

(2011) Friederike Pfeiffer et al.   ACTA NEUROPATHOLOGICA

Tight Junctions in Brain Barriers During Central Nervous System Inflammation

(2011) Caroline Coisne et al.   ANTIOXIDANTS & REDOX SIGNALING

Amyloid Beta Induces Oxidative Stress-Mediated Blood–Brain Barrier Changes in Capillary Amyloid Angiopathy

(2011) Anna Carrano et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells

(2011) Jingqi Yan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

HIV-1 gp120 upregulates matrix metalloproteinases and their inhibitors in a rat model of HIV encephalopathy

(2011) Jean-Pierre Louboutin et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

How do immune cells overcome the blood-brain barrier in multiple sclerosis?

(2011) Catherine Larochelle et al.   FEBS LETTERS

Hepatitis C Virus Infects the Endothelial Cells of the Blood-Brain Barrier

(2011) Nicola F. Fletcher et al.   GASTROENTEROLOGY

Interendothelial Claudin-5 Expression Depends on Cerebral Endothelial Cell–Matrix Adhesion by β1-Integrins

(2011) Takashi Osada et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo

(2011) Andre Broermann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of Glucocorticoids in the Control of Neuroinflammation

(2011) N. Schweingruber et al.   JOURNAL OF NEUROENDOCRINOLOGY

Brain pericytes among cells constituting the blood-brain barrier are highly sensitive to tumor necrosis factor-α, releasing matrix metalloproteinase-9 and migrating in vitro

(2011) Fuyuko Takata et al.   Journal of Neuroinflammation

Changes in Brain β-Amyloid Deposition and Aquaporin 4 Levels in Response to AlteredAgrinExpression in Mice

(2011) Steven M. Rauch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Disruption of neurovascular unit prior to motor neuron degeneration in amyotrophic lateral sclerosis

(2011) Kazunori Miyazaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Free-Radical Scavenger Edaravone Treatment Confers Neuroprotection Against Traumatic Brain Injury in Rats

(2011) Guo-Hua Wang et al.   JOURNAL OF NEUROTRAUMA

Caffeic Acid Phenethyl Ester Protects Blood–Brain Barrier Integrity and Reduces Contusion Volume in Rodent Models of Traumatic Brain Injury

(2011) Jing Zhao et al.   JOURNAL OF NEUROTRAUMA

TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

(2011) Ha-Long Nguyen et al.   LABORATORY INVESTIGATION

Metabolic Modulation of Cytokine-Induced Brain Endothelial Adhesion Molecule Expression

(2011) GANTA VIJAY CHAITANYA et al.   MICROCIRCULATION

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Suppression of local inflammation contributes to the neuroprotective effect of ginsenoside Rb1 in rats with cerebral ischemia

(2011) J. Zhu et al.   NEUROSCIENCE

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Structural insights into de novo actin polymerization

(2010) Roberto Dominguez   CURRENT OPINION IN STRUCTURAL BIOLOGY

Annexin 2 Regulates Endothelial Morphogenesis by Controlling AKT Activation and Junctional Integrity

(2010) Shih-Chi Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular Endothelial Growth Factor Increases Permeability of the Blood–Tumor Barrier via Caveolae-Mediated Transcellular Pathway

(2010) Li-ni Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Peroxisome Proliferator-Activated Receptor   Regulation of miR-15a in Ischemia-Induced Cerebral Vascular Endothelial Injury

(2010) K. J. Yin et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor-α Mediates the Blood–Brain Barrier Dysfunction Induced by Activated Microglia in Mouse Brain Microvascular Endothelial Cells

(2010) Tsuyoshi Nishioku et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Role of matrix metalloproteinase-9 (MMP-9) in striatal blood-brain barrier disruption in a 3-nitropropionic acid model of Huntington's disease

(2010) J. Duran-Vilaregut et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Rho Signaling and Tight Junction Functions

(2010) Steve Terry et al.   PHYSIOLOGY

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

(2009) Andreas Junker et al.   BRAIN

Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood–brain barrier disruption after global cerebral ischemia

(2009) Ewa Baumann et al.   BRAIN RESEARCH

Different circulating metalloproteinases profiles in women with migraine with and without aura

(2009) Alisson Martins-Oliveira et al.   CLINICA CHIMICA ACTA

CSD, BBB and MMP-9 elevations: animal experiments versus clinical phenomena in migraine

(2009) Vinod Kumar Gupta   Expert Review of Neurotherapeutics

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown

(2009) Azeb Tadesse Argaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opening of the blood-brain barrier during isoflurane anaesthesia

(2008) Samuel Tétrault et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF

(2008) Astrid F. Nottebaum et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic–ischemic model

(2008) Wanqiu Chen et al.   NEUROBIOLOGY OF DISEASE

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Annexin A1 in the brain – undiscovered roles?

(2008) Egle Solito et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PECAM-1 isoform-specific functions in PECAM-1-deficient brain microvascular endothelial cells

(2007) Terri A. DiMaio et al.   MICROVASCULAR RESEARCH