Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogen-activated protein kinases and death in tumor cells

The Targets of Curcumin

(2012) Hongyu Zhou et al.   CURRENT DRUG TARGETS

Dimethoxycurcumin, a metabolically stable analogue of curcumin, exhibits anti-inflammatory activities in murine and human lymphocytes

(2011) Raghavendra S. Patwardhan et al.   BIOCHEMICAL PHARMACOLOGY

Curcumin Induces Small Cell Lung Cancer NCI-H446 Cell Apoptosis via the Reactive Oxygen Species-Mediated Mitochondrial Pathway and Not the Cell Death Receptor Pathway

(2011) Cheng-Liang Yang et al.   DNA AND CELL BIOLOGY

Curcumin nanodisk-induced apoptosis in mantle cell lymphoma

(2011) Amareshwar T. K. Singh et al.   LEUKEMIA & LYMPHOMA

Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells

(2011) Jia-Ching Wu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy

(2011) Jen-Yi Lee et al.   PLoS One

Pathological roles of MAPK signaling pathways in human diseases

(2010) Eun Kyung Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

(2009) C. S. Beevers et al.   CANCER RESEARCH

p21Waf1/Cip1 Expression by Curcumin in U-87MG Human Glioma Cells: Role of Early Growth Response-1 Expression

(2008) B. H. Choi et al.   CANCER RESEARCH

Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5

(2008) Long Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

(2008) Long Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

(2008) S. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Curcumin as “Curecumin”: From kitchen to clinic

(2007) Ajay Goel et al.   BIOCHEMICAL PHARMACOLOGY