Profilin 1 deficiency drives mitotic defects and reduces genome stability

Visualizing molecules of functional human profilin

(2022) Morgan L Pimm et al.   eLife

Cellular Pushing Forces during Mitosis Drive Mitotic Elongation in Collagen Gels

(2021) Sungmin Nam et al.   Advanced Science

Mutations in Profilin 1 Cause Early‐Onset Paget's Disease of Bone With Giant Cell Tumors

(2021) Zhe Wei et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Chromothripsis as an on-target consequence of CRISPR–Cas9 genome editing

(2021) Mitchell L. Leibowitz et al.   NATURE GENETICS

iASPP contributes to cell cortex rigidity, mitotic cell rounding, and spindle positioning

(2021) Aurélie Mangon et al.   JOURNAL OF CELL BIOLOGY

Whole chromosome loss and genomic instability in mouse embryos after CRISPR-Cas9 genome editing

(2021) Stamatis Papathanasiou et al.   Nature Communications

The Loss of Profilin 1 Causes Early Onset Paget's Disease of Bone

(2020) Federica Scotto di Carlo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pan-cancer analysis of whole genomes

(2020)   NATURE

The evolutionary history of 2,658 cancers

(2020) Moritz Gerstung et al.   NATURE

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

(2020) Isidro Cortés-Ciriano et al.   NATURE GENETICS

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division

(2020) Lovorka Stojic et al.   Nature Communications

Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53-Deficient Cells

(2020) Alexandros P. Drainas et al.   Cell Reports

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis

(2020) John Maciejowski et al.   NATURE GENETICS

The Mechanics of Mitotic Cell Rounding

(2020) Anna V. Taubenberger et al.   Frontiers in Cell and Developmental Biology

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

(2019) Koutarou Nishimura et al.   Nature Communications

Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways

(2019) Christopher D. Steele et al.   CANCER CELL

Centromere mechanical maturation during mammalian cell mitosis

(2019) Lauren A. Harasymiw et al.   Nature Communications

Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

(2019) Therese Wilhelm et al.   Nature Communications

The impact of mitotic errors on cell proliferation and tumorigenesis

(2018) Michelle S. Levine et al.   GENES & DEVELOPMENT

SvABA: genome-wide detection of structural variants and indels by local assembly

(2018) Jeremiah A. Wala et al.   GENOME RESEARCH

Strelka2: fast and accurate calling of germline and somatic variants

(2018) Sangtae Kim et al.   NATURE METHODS

Determinants and clinical implications of chromosomal instability in cancer

(2018) Laurent Sansregret et al.   Nature Reviews Clinical Oncology

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Germline and somatic genetics of osteosarcoma — connecting aetiology, biology and therapy

(2017) D. Matthew Gianferante et al.   Nature Reviews Endocrinology

Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma

(2017) Sam Behjati et al.   Nature Communications

Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding

(2017) Yusuke Toyoda et al.   Nature Communications

Aneuploidy in Cancer and Aging

(2016) Ryan M. Naylor et al.   Annual Review of Genetics

Coupling changes in cell shape to chromosome segregation

(2016) Nitya Ramkumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The presence of extra chromosomes leads to genomic instability

(2016) Verena Passerini et al.   Nature Communications

CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing

(2016) Eric Talevich et al.   PLoS Computational Biology

Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications

(2015) Xiaoyu Chen et al.   BIOINFORMATICS

A cell-based model system links chromothripsis with hyperploidy

(2015) B. R. Mardin et al.   Molecular Systems Biology

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Short- and long-term effects of chromosome mis-segregation and aneuploidy

(2015) Stefano Santaguida et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Numerical chromosomal instability mediates susceptibility to radiation treatment

(2015) Samuel F. Bakhoum et al.   Nature Communications

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis

(2014) Wantong Yao et al.   Molecular Cancer

Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation

(2014) Yi Fan et al.   NATURE CELL BIOLOGY

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

(2014) Jennifer A. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

LUMPY: a probabilistic framework for structural variant discovery

(2014) Ryan M Layer et al.   GENOME BIOLOGY

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

Aneuploidy and chromosomal instability: a vicious cycle driving cellular evolution and cancer genome chaos

(2013) Tamara A. Potapova et al.   CANCER AND METASTASIS REVIEWS

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

Profilin-1 downregulation has contrasting effects on early vs late steps of breast cancer metastasis

(2013) Z Ding et al.   ONCOGENE

2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells

(2013) Lauren M. Zasadil et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

DELLY: structural variant discovery by integrated paired-end and split-read analysis

(2012) T. Rausch et al.   BIOINFORMATICS

Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

(2012) D. A. Moulding et al.   BLOOD

Profilin 1 is a Potential Biomarker for Bladder Cancer Aggressiveness

(2011) Jerome Zoidakis et al.   MOLECULAR & CELLULAR PROTEOMICS

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation

(2011) Chen Luxenburg et al.   NATURE CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy

(2010) S Tommasi et al.   ONCOGENE

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Osteosarcoma incidence and survival rates from 1973 to 2004

(2009) Lisa Mirabello et al.   CANCER

Profilin 1 is required for abscission during late cytokinesis of chondrocytes

(2009) Ralph T Böttcher et al.   EMBO JOURNAL

The actin cytoskeleton in spindle assembly and positioning

(2009) Patricia Kunda et al.   TRENDS IN CELL BIOLOGY

Moesin Controls Cortical Rigidity, Cell Rounding, and Spindle Morphogenesis during Mitosis

(2008) Patricia Kunda et al.   CURRENT BIOLOGY

Vesicles and actin are targeted to the cleavage furrow via furrow microtubules and the central spindle

(2008) Roger Albertson et al.   JOURNAL OF CELL BIOLOGY

Osteosarcoma in Patients Older Than 65 Years

(2008) Alessandra Longhi et al.   JOURNAL OF CLINICAL ONCOLOGY