The Mechanics of Mitotic Cell Rounding

F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis

(2020) Murielle P. Serres et al.   DEVELOPMENTAL CELL

Oncogenic Signaling Alters Cell Shape and Mechanics to Facilitate Cell Division under Confinement

(2020) Helen K. Matthews et al.   DEVELOPMENTAL CELL

Adherens junction remodelling during mitotic rounding of pseudostratified epithelial cells

(2020) Mario Aguilar‐Aragon et al.   EMBO REPORTS

A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity

(2020) Louisa Nelson et al.   Nature Communications

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Isotropic myosin-generated tissue tension is required for the dynamic orientation of the mitotic spindle

(2020) Maxine S. Y. Lam et al.   MOLECULAR BIOLOGY OF THE CELL

SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization

(2020) Luyan Cao et al.   NATURE CELL BIOLOGY

Mechanics of the cellular actin cortex: From signalling to shape change

(2020) Manasi Kelkar et al.   CURRENT OPINION IN CELL BIOLOGY

Noninvasive monitoring of single-cell mechanics by acoustic scattering

(2019) Joon Ho Kang et al.   NATURE METHODS

Label‐free multi‐parametric imaging of single cells: dual picosecond optoacoustic microscopy

(2019) Liwang Liu et al.   Journal of Biophotonics

Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity

(2019) Martim Dias Gomes et al.   Nature Communications

Brillouin microscopy: an emerging tool for mechanobiology

(2019) Robert Prevedel et al.   NATURE METHODS

Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division

(2019) Sofia Duarte et al.   Nature Communications

Oriented cell divisions in epithelia: from force generation to force anisotropy by tension, shape and vertices

(2019) Eric Victor van Leen et al.   CURRENT OPINION IN CELL BIOLOGY

Two-step interphase microtubule disassembly aids spindle morphogenesis

(2018) Nunu Mchedlishvili et al.   BMC BIOLOGY

Architecture shapes contractility in actomyosin networks

(2018) Gijsje H Koenderink et al.   CURRENT OPINION IN CELL BIOLOGY

The Role of Mitotic Cell-Substrate Adhesion Re-modeling in Animal Cell Division

(2018) Christina L. Dix et al.   DEVELOPMENTAL CELL

Structural centrosome aberrations promote non‐cell‐autonomous invasiveness

(2018) Olivier Ganier et al.   EMBO JOURNAL

Cell adhesion is regulated by CDK1 during the cell cycle

(2018) Matthew C. Jones et al.   JOURNAL OF CELL BIOLOGY

The actin cortex at a glance

(2018) Priyamvada Chugh et al.   JOURNAL OF CELL SCIENCE

Biomechanical and biomolecular characterization of extracellular matrix structures in human colon carcinomas

(2018) Eva Brauchle et al.   MATRIX BIOLOGY

Regulation of cell cycle progression by cell–cell and cell–matrix forces

(2018) Marina Uroz et al.   NATURE CELL BIOLOGY

Real-time fluorescence and deformability cytometry

(2018) Philipp Rosendahl et al.   NATURE METHODS

A comparison of methods to assess cell mechanical properties

(2018) Pei-Hsun Wu et al.   NATURE METHODS

Mitotic cells generate protrusive extracellular forces to divide in three-dimensional microenvironments

(2018) Sungmin Nam et al.   Nature Physics

Size control in mammalian cells involves modulation of both growth rate and cell cycle duration

(2018) Clotilde Cadart et al.   Nature Communications

Fluidization-mediated tissue spreading by mitotic cell rounding and non-canonical Wnt signalling

(2018) Nicoletta I. Petridou et al.   NATURE CELL BIOLOGY

Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis

(2018) John G. Lock et al.   NATURE CELL BIOLOGY

Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells

(2017) Alexander D. Rhys et al.   JOURNAL OF CELL BIOLOGY

Pseudostratified epithelia – cell biology, diversity and roles in organ formation at a glance

(2017) Caren Norden   JOURNAL OF CELL SCIENCE

Actin cortex architecture regulates cell surface tension

(2017) Priyamvada Chugh et al.   NATURE CELL BIOLOGY

E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape

(2017) Kevin C. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Reorganization during Mitotic Entry

(2017) Lysie Champion et al.   TRENDS IN CELL BIOLOGY

Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells

(2017) Chantal Roubinet et al.   Nature Communications

Cell division orientation is coupled to cell–cell adhesion by the E-cadherin/LGN complex

(2017) Martijn Gloerich et al.   Nature Communications

Genome-scale single-cell mechanical phenotyping reveals disease-related genes involved in mitotic rounding

(2017) Yusuke Toyoda et al.   Nature Communications

Multi-scale computational study of the mechanical regulation of cell mitotic rounding in epithelia

(2017) Ali Nematbakhsh et al.   PLoS Computational Biology

Mitosis can drive cell cannibalism through entosis

(2017) Joanne Durgan et al.   eLife

Numerical Simulation of Real-Time Deformability Cytometry To Extract Cell Mechanical Properties

(2017) M. Mokbel et al.   ACS Biomaterials-Science & Engineering

Numerical Simulation of Real-Time Deformability Cytometry To Extract Cell Mechanical Properties

(2017) M. Mokbel et al.   ACS Biomaterials Science & Engineering

Molecular Insights into Division of Single Human Cancer Cells in On-Chip Transparent Microtubes

(2016) Wang Xi et al.   ACS Nano

Rheology of the Active Cell Cortex in Mitosis

(2016) Elisabeth Fischer-Friedrich et al.   BIOPHYSICAL JOURNAL

Actomyosin Cortical Mechanical Properties in Nonadherent Cells Determined by Atomic Force Microscopy

(2016) Alexander X. Cartagena-Rivera et al.   BIOPHYSICAL JOURNAL

Architecture and Connectivity Govern Actin Network Contractility

(2016) Hajer Ennomani et al.   CURRENT BIOLOGY

Cell Division Drives Epithelial Cell Rearrangements during Gastrulation in Chick

(2016) Joao Firmino et al.   DEVELOPMENTAL CELL

The Actin Cortex: A Bridge between Cell Shape and Function

(2016) Kevin J. Chalut et al.   DEVELOPMENTAL CELL

Regulation of mitotic spindle orientation: an integrated view

(2016) Florencia di Pietro et al.   EMBO REPORTS

Coordination of signaling and tissue mechanics during morphogenesis of murine intestinal villi: a role for mitotic cell rounding

(2016) Andrew M. Freddo et al.   Integrative Biology

Coupling changes in cell shape to chromosome segregation

(2016) Nitya Ramkumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Memory of cell shape biases stochastic fate decision-making despite mitotic rounding

(2016) Takashi Akanuma et al.   Nature Communications

The Role of Aneuploidy in Cancer Evolution

(2016) Laurent Sansregret et al.   Cold Spring Harbor Perspectives in Medicine

Extracting Cell Stiffness from Real-Time Deformability Cytometry: Theory and Experiment

(2015) Alexander Mietke et al.   BIOPHYSICAL JOURNAL

Properties of cells through life and death – an acoustic microscopy investigation

(2015) Maurice M Pasternak et al.   CELL CYCLE

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry

(2015) André Rosa et al.   DEVELOPMENTAL CELL

Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration

(2015) I. Acerbi et al.   Integrative Biology

Optical volume and mass measurements show that mammalian cells swell during mitosis

(2015) Ewa Zlotek-Zlotkiewicz et al.   JOURNAL OF CELL BIOLOGY

Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis

(2015) Sungmin Son et al.   JOURNAL OF CELL BIOLOGY

Kinetochore-localized PP1–Sds22 couples chromosome segregation to polar relaxation

(2015) Nelio T. L. Rodrigues et al.   NATURE

Cdk1-dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement

(2015) Subramanian P. Ramanathan et al.   NATURE CELL BIOLOGY

Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

(2015) Spencer C. Wei et al.   NATURE CELL BIOLOGY

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

(2015) Oliver Otto et al.   NATURE METHODS

Emergence of homeostatic epithelial packing and stress dissipation through divisions oriented along the long cell axis

(2015) Tom P. J. Wyatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical control of mitotic progression in single animal cells

(2015) Cedric J. Cattin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

The mechanical microenvironment in cancer: How physics affects tumours

(2015) Anika Nagelkerke et al.   SEMINARS IN CANCER BIOLOGY

Imaging viscoelastic properties of live cells by AFM: power-law rheology on the nanoscale

(2015) Fabian M. Hecht et al.   Soft Matter

A narrow window of cortical tension guides asymmetric spindle positioning in the mouse oocyte

(2015) A. Chaigne et al.   Nature Communications

Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinement

(2015) Barbara Sorce et al.   Nature Communications

Mitotic cell rounding and epithelial thinning regulate lumen growth and shape

(2015) Esteban Hoijman et al.   Nature Communications

Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration

(2015) Jeremy S Logue et al.   eLife

ERK reinforces actin polymerization to power persistent edge protrusion during motility

(2015) Michelle C. Mendoza et al.   Science Signaling

Cellular Control of Cortical Actin Nucleation

(2014) Miia Bovellan et al.   CURRENT BIOLOGY

Stresses at the Cell Surface during Animal Cell Morphogenesis

(2014) Andrew G. Clark et al.   CURRENT BIOLOGY

Exploring the Function of Cell Shape and Size during Mitosis

(2014) Clotilde Cadart et al.   DEVELOPMENTAL CELL

Cell division and the maintenance of epithelial order

(2014) Katerina Ragkousi et al.   JOURNAL OF CELL BIOLOGY

SLK-dependent activation of ERMs controls LGN–NuMA localization and spindle orientation

(2014) Mickael Machicoane et al.   JOURNAL OF CELL BIOLOGY

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cell mechanics: principles, practices, and prospects

(2014) Emad Moeendarbary et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Atomic force microscopy-based microrheology reveals significant differences in the viscoelastic response between malign and benign cell lines

(2014) J. Rother et al.   Open Biology

Monitoring Actin Cortex Thickness in Live Cells

(2013) Andrew G. Clark et al.   BIOPHYSICAL JOURNAL

Cortical Dynein and Asymmetric Membrane Elongation Coordinately Position the Spindle in Anaphase

(2013) Tomomi Kiyomitsu et al.   CELL

Oriented divisions, fate decisions

(2013) Scott E Williams et al.   CURRENT OPINION IN CELL BIOLOGY

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging

(2013) Maté Biro et al.   Cytoskeleton

Mitotic Rounding Alters Cell Geometry to Ensure Efficient Bipolar Spindle Formation

(2013) Oscar M. Lancaster et al.   DEVELOPMENTAL CELL

Wedged AFM-cantilevers for parallel plate cell mechanics

(2013) Martin P. Stewart et al.   METHODS

Measurements of forces produced by the mitotic spindle using optical tweezers

(2013) Jessica Ferraro-Gideon et al.   MOLECULAR BIOLOGY OF THE CELL

Epithelial junctions maintain tissue architecture by directing planar spindle orientation

(2013) Yu-ichiro Nakajima et al.   NATURE

Mitotic cell rounding accelerates epithelial invagination

(2013) Takefumi Kondo et al.   NATURE

A soft cortex is essential for asymmetric spindle positioning in mouse oocytes

(2013) Agathe Chaigne et al.   NATURE CELL BIOLOGY

The cytoplasm of living cells behaves as a poroelastic material

(2013) Emad Moeendarbary et al.   NATURE MATERIALS

The Ras-ERK pathway modulates cytoskeleton organization, cell motility and lung metastasis signature genes in MDA-MB-231 LM2

(2013) C Choi et al.   ONCOGENE

Cytokinesis in Animal Cells

(2012) Rebecca A. Green et al.   Annual Review of Cell and Developmental Biology

The metastatic cancer cell cortex: An adaptation to enhance robust cell division in novel environments?

(2012) Helen K. Matthews et al.   BIOESSAYS

Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity

(2012) D. A. Moulding et al.   BLOOD

Changes in Ect2 Localization Couple Actomyosin-Dependent Cell Shape Changes to Mitotic Progression

(2012) Helen K. Matthews et al.   DEVELOPMENTAL CELL

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens

(2012) Aparna Ratheesh et al.   NATURE CELL BIOLOGY

The nanomechanical signature of breast cancer

(2012) Marija Plodinec et al.   Nature Nanotechnology

Tracking mechanics and volume of globular cells with atomic force microscopy using a constant-height clamp

(2012) Martin P Stewart et al.   Nature Protocols

In vivo Brillouin optical microscopy of the human eye

(2012) Giuliano Scarcelli et al.   OPTICS EXPRESS

Increased Asymmetric and Multi-Daughter Cell Division in Mechanically Confined Microenvironments

(2012) Henry Tat Kwong Tse et al.   PLoS One

Viscoelastic Properties of Differentiating Blood Cells Are Fate- and Function-Dependent

(2012) Andrew E. Ekpenyong et al.   PLoS One

Mechanical impulses can control metaphase progression in a mammalian cell

(2012) T. Itabashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

(2012) T. Stylianopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin cortex mechanics and cellular morphogenesis

(2012) Guillaume Salbreux et al.   TRENDS IN CELL BIOLOGY

Spindle Pole Mechanics Studied in Mitotic Asters: Dynamic Distribution of Spindle Forces through Compliant Linkages

(2011) Blake D. Charlebois et al.   BIOPHYSICAL JOURNAL

Interkinetic Nuclear Migration Is a Broadly Conserved Feature of Cell Division in Pseudostratified Epithelia

(2011) Emily J. Meyer et al.   CURRENT BIOLOGY

PP1-Mediated Moesin Dephosphorylation Couples Polar Relaxation to Mitotic Exit

(2011) Patricia Kunda et al.   CURRENT BIOLOGY

Targeting of the RhoGEF Ect2 to the Equatorial Membrane Controls Cleavage Furrow Formation during Cytokinesis

(2011) Kuan-Chung Su et al.   DEVELOPMENTAL CELL

Molecular networks linked by Moesin drive remodeling of the cell cortex during mitosis

(2011) Chantal Roubinet et al.   JOURNAL OF CELL BIOLOGY

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

(2011) Jakub Sedzinski et al.   NATURE

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation

(2011) Chen Luxenburg et al.   NATURE CELL BIOLOGY

Spatial regulation of Dia and Myosin-II by RhoGEF2 controls initiation of E-cadherin endocytosis during epithelial morphogenesis

(2011) Romain Levayer et al.   NATURE CELL BIOLOGY

Force probing cell shape changes to molecular resolution

(2011) Martin P. Stewart et al.   TRENDS IN BIOCHEMICAL SCIENCES

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

Cortical Mechanics and Meiosis II Completion in Mammalian Oocytes Are Mediated by Myosin-II and Ezrin-Radixin-Moesin (ERM) Proteins

(2010) Stephanie M. Larson et al.   MOLECULAR BIOLOGY OF THE CELL

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding

(2010) Martin P. Stewart et al.   NATURE

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Compression Regulates Mitotic Spindle Length by a Mechanochemical Switch at the Poles

(2009) Sophie Dumont et al.   CURRENT BIOLOGY

Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis

(2009) V. T. Dao et al.   JOURNAL OF CELL SCIENCE

Role of cortical tension in bleb growth

(2009) J.-Y. Tinevez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between Myosin and Actin Crosslinkers Control Cytokinesis Contractility Dynamics and Mechanics

(2008) Elizabeth M. Reichl et al.   CURRENT BIOLOGY

Moesin Controls Cortical Rigidity, Cell Rounding, and Spindle Morphogenesis during Mitosis

(2008) Patricia Kunda et al.   CURRENT BIOLOGY

Cytokinesis of neuroepithelial cells can divide their basal process before anaphase

(2008) Yoichi Kosodo et al.   EMBO JOURNAL

Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells

(2008) Sébastien Carreno et al.   JOURNAL OF CELL BIOLOGY

Tensile forces govern germ-layer organization in zebrafish

(2008) M. Krieg et al.   NATURE CELL BIOLOGY

Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates

(2008) J. D. Blethrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA