Linking Lichen Metabolites to Genes: Emerging Concepts and Lessons from Molecular Biology and Metagenomics

A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi

(2022) Garima Singh et al.   Microbiology Spectrum

Unraveling usnic acid: A comparison of biosynthetic gene clusters between two reindeer lichen (Cladonia rangiferina and C. uncialis)

(2022) Susan Egbert et al.   Fungal Biology

MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters

(2022) Barbara R Terlouw et al.   NUCLEIC ACIDS RESEARCH

antiSMASH 6.0: improving cluster detection and comparison capabilities

(2021) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

An interpreted atlas of biosynthetic gene clusters from 1,000 fungal genomes

(2021) Matthew T. Robey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Climate‐specific biosynthetic gene clusters in populations of a lichen‐forming fungus

(2021) Garima Singh et al.   ENVIRONMENTAL MICROBIOLOGY

Linking a Gene Cluster to Atranorin, a Major Cortical Substance of Lichens, through Genetic Dereplication and Heterologous Expression

(2021) Wonyong Kim et al.   mBio

Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain

(2021) Yucong Zhou et al.   ACS Catalysis

Linking Genes to Molecules in Eukaryotic Sources: An Endeavor to Expand Our Biosynthetic Repertoire

(2020) Jack G. Ganley et al.   MOLECULES

Genome-wide analysis of biosynthetic gene cluster reveals correlated gene loss with absence of usnic acid in lichen forming fungi

(2020) David Pizarro et al.   Genome Biology and Evolution

BiG-FAM: the biosynthetic gene cluster families database

(2020) Satria A Kautsar et al.   NUCLEIC ACIDS RESEARCH

Unraveling the Pharmacological Potential of Lichen Extracts in the Context of Cancer and Inflammation With a Broad Screening Approach

(2020) Rebecca Ingelfinger et al.   Frontiers in Pharmacology

Biosynthetic Gene Content of the ‘Perfume Lichens’ Evernia prunastri and Pseudevernia furfuracea

(2019) Anjuli Calchera et al.   MOLECULES

Lost in Translation: Challenges with Heterologous Expression of Lichen Polyketide Synthases

(2019) Robert L. Bertrand et al.   ChemistrySelect

A computational framework to explore large-scale biosynthetic diversity

(2019) Jorge C. Navarro-Muñoz et al.   Nature Chemical Biology

A database of high-resolution MS/MS spectra for lichen metabolites

(2019) Damien Olivier-Jimenez et al.   Scientific Data

Secondary metabolism in the lichen symbiosis

(2018) Mark J. Calcott et al.   CHEMICAL SOCIETY REVIEWS

UPLC–MS/MS quantitative analysis and structural fragmentation study of five Parmotrema lichens from the Eastern Ghats

(2018) K. Kumar et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens

(2018) Yi Wang et al.   PLoS One

Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase

(2018) Martin Sabatini et al.   FEBS Journal

Fungal secondary metabolism: regulation, function and drug discovery

(2018) Nancy P. Keller   NATURE REVIEWS MICROBIOLOGY

Metabolomic Analysis of Two Parmotrema Lichens: P. robustum (Degel.) Hale and P. andinum (Mull. Arg.) Hale Using UHPLC-ESI-OT-MS-MS

(2017) Alfredo Torres-Benítez et al.   MOLECULES

Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases

(2017) Jesus F. Barajas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequencing genomes from mixed DNA samples - evaluating the metagenome skimming approach in lichenized fungi

(2017) Anjuli Meiser et al.   Scientific Reports

Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain

(2016) Jesus F. Barajas et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Putative identification of the usnic acid biosynthetic gene cluster by de novo whole-genome sequencing of a lichen-forming fungus

(2016) Mona Abdel-Hameed et al.   Fungal Biology

Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products

(2016) Yong Fuga Li et al.   FUNGAL GENETICS AND BIOLOGY

Evaluation of antioxidant and cytotoxic effects of olivetoric and physodic acid in cultured human amnion fibroblasts

(2016) B Emsen et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Secondary metabolites from cetrarioid lichens: Chemotaxonomy, biological activities and pharmaceutical potential

(2016) Maonian Xu et al.   PHYTOMEDICINE

Bioinformatical Analysis of the Sequences, Structures and Functions of Fungal Polyketide Synthase Product Template Domains

(2015) Lu Liu et al.   Scientific Reports

Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi

(2015) Ralph A. Cacho et al.   Frontiers in Microbiology

Recent advances in genome mining of secondary metabolites in Aspergillus terreus

(2014) Chun-Jun Guo et al.   Frontiers in Microbiology

Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Mycotoxins

(2013) Antonia Gallo et al.   Toxins

Demonstration of Starter Unit Interprotein Transfer from a Fatty Acid Synthase to a Multidomain, Nonreducing Polyketide Synthase

(2012) Jennifer Foulke-Abel et al.   CHEMBIOCHEM

Genome mining reveals the evolutionary origin and biosynthetic potential of basidiomycete polyketide synthases

(2012) Gerald Lackner et al.   FUNGAL GENETICS AND BIOLOGY

Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

(2012) Yit-Heng Chooi et al.   JOURNAL OF ORGANIC CHEMISTRY

Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

(2012) Manmeet Ahuja et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone

(2011) Daniele Armaleo et al.   MYCOLOGIA

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes

(2010) Shu-Ming Li   JOURNAL OF ANTIBIOTICS

Classification, Prediction, and Verification of the Regioselectivity of Fungal Polyketide Synthase Product Template Domains

(2010) Yanran Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The natural history of antibiotics

(2009) Jon Clardy et al.   CURRENT BIOLOGY

Microbial drug discovery: 80 years of progress

(2009) Arnold L Demain et al.   JOURNAL OF ANTIBIOTICS

Phylogenetic relationships and species circumscription in Trentepohlia and Printzina (Trentepohliales, Chlorophyta)

(2009) Fabio Rindi et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Starter unit specificity directs genome mining of polyketide synthase pathways in fungi

(2008) Jason M. Crawford et al.   BIOORGANIC CHEMISTRY

Deconstruction of Iterative Multidomain Polyketide Synthase Function

(2008) J. M. Crawford et al.   SCIENCE

Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimatemetabolite production, and PKS genes

(2007) Elfie Stocker-Wörgötter   NATURAL PRODUCT REPORTS