Biochemical characterization of the minimal domains of an iterative eukaryotic polyketide synthase

Characterization of the Polyspecific Transferase of Murine Type I Fatty Acid Synthase (FAS) and Implications for Polyketide Synthase (PKS) Engineering

(2018) Alexander Rittner et al.   ACS Chemical Biology

Expanding the product portfolio of fungal type I fatty acid synthases

(2017) Zhiwei Zhu et al.   Nature Chemical Biology

Engineering fatty acid synthases for directed polyketide production

(2017) Jan Gajewski et al.   Nature Chemical Biology

Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

(2017) Douglas M. Roberts et al.   Chemical Science

Engineering fungal de novo fatty acid synthesis for short chain fatty acid production

(2017) Jan Gajewski et al.   Nature Communications

Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase

(2016) Thomas Robbins et al.   BIOCHEMISTRY

Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases

(2016) Maja Klaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets

(2016) Sudhir Kumar et al.   MOLECULAR BIOLOGY AND EVOLUTION

A hybrid polyketide–nonribosomal peptide in nematodes that promotes larval survival

(2016) Qingyao Shou et al.   Nature Chemical Biology

Structural and Functional Analysis of the Loading Acyltransferase from Avermectin Modular Polyketide Synthase

(2015) Fen Wang et al.   ACS Chemical Biology

Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase

(2015) Ralph A. Cacho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unexpected link between polyketide synthase and calcium carbonate biomineralization

(2015) Motoki Hojo et al.   Zoological Letters

Comparative Analysis of the Substrate Specificity of trans- versus cis-Acyltransferases of Assembly Line Polyketide Synthases

(2014) Briana J. Dunn et al.   BIOCHEMISTRY

Modular Polyketide Synthases (PKSs): A New Model Fits All?

(2014) Alexander Rittner et al.   CHEMBIOCHEM

Systematic Domain Swaps of Iterative, Nonreducing Polyketide Synthases Provide a Mechanistic Understanding and Rationale For Catalytic Reprogramming

(2014) Adam G. Newman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism and Specificity of an Acyltransferase Domain from a Modular Polyketide Synthase

(2013) Briana J. Dunn et al.   BIOCHEMISTRY

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

(2013) B. J. Dunn et al.   Journal of the Royal Society Interface

The structural role of the carrier protein – active controller or passive carrier

(2012) John Crosby et al.   NATURAL PRODUCT REPORTS

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase

(2010) S. Kapur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases

(2009) Gabor Bunkoczi et al.   CHEMISTRY & BIOLOGY