Quantitative Serum NMR Spectroscopy Stratifies COVID-19 Patients and Sheds Light on Interfaces of Host Metabolism and the Immune Response with Cytokines and Clinical Parameters

J-Edited DIffusional Proton Nuclear Magnetic Resonance Spectroscopic Measurement of Glycoprotein and Supramolecular Phospholipid Biomarkers of Inflammation in Human Serum

(2022) Philipp Nitschke et al.   ANALYTICAL CHEMISTRY

COVID-19 will continue but the end of the pandemic is near

(2022) Christopher J L Murray   LANCET

An outpatient management strategy using a Coronataxi digital early warning (CDEW) system reduces COVID-19 mortality

(2022) Adeline Lim et al.   Open Forum Infectious Diseases

Exploration of Human Serum Lipoprotein Supramolecular Phospholipids Using Statistical Heterospectroscopy in n-Dimensions (SHY-n): Identification of Potential Cardiovascular Risk Biomarkers Related to SARS-CoV-2 Infection

(2022) Reika Masuda et al.   ANALYTICAL CHEMISTRY

Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients

(2022) Veronica Ghini et al.   PLoS Pathogens

Immunophenotyping of lymphocytes and monocytes and the status of cytokines in the clinical course of Covid‐19 patients

(2022) Ufuk O. Idiz et al.   JOURNAL OF MEDICAL VIROLOGY

1H qNMR-Based Metabolomics Discrimination of Covid-19 Severity

(2022) Banny S. B. Correia et al.   JOURNAL OF PROTEOME RESEARCH

Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

(2022) Fotios Karagiannis et al.   NATURE

Symptoms and risk factors for long COVID in non-hospitalized adults

(2022) Anuradhaa Subramanian et al.   NATURE MEDICINE

Ketone Bodies Improve Human CD8+ Cytotoxic T-Cell Immune Response During COVID-19 Infection

(2022) Simon Hirschberger et al.   Frontiers in Medicine

Circulating pyruvate is a potent prognostic marker for critical COVID-19 outcomes

(2022) Victòria Ceperuelo-Mallafré et al.   Frontiers in Immunology

Is COVID-19 Gender-sensitive?

(2021) Shreya Mukherjee et al.   Journal of Neuroimmune Pharmacology

NMR Spectroscopic Windows on the Systemic Effects of SARS-CoV-2 Infection on Plasma Lipoproteins and Metabolites in Relation to Circulating Cytokines

(2021) Samantha Lodge et al.   JOURNAL OF PROTEOME RESEARCH

Altered high-density lipoprotein composition and functions during severe COVID-19

(2021) Floran Begue et al.   Scientific Reports

Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets

(2021) Zhiqiang Pang et al.   Metabolites

Diffusion and Relaxation Edited Proton NMR Spectroscopy of Plasma Reveals a High-Fidelity Supramolecular Biomarker Signature of SARS-CoV-2 Infection

(2021) Samantha Lodge et al.   ANALYTICAL CHEMISTRY

The role of C-reactive protein as a prognostic marker in COVID-19

(2021) Dominic Stringer et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Liver injury in the era of COVID-19

(2021) Halina Cichoż-Lach et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab

(2021) Gaia Meoni et al.   PLoS Pathogens

SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment

(2021) Chien-Ting Wu et al.   Cell Metabolism

Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.

(2021) Laura Bergamaschi et al.   IMMUNITY

Metabolic dysfunction and immunometabolism in COVID-19 pathophysiology and therapeutics

(2021) Rachael Batabyal et al.   INTERNATIONAL JOURNAL OF OBESITY

Enemy or ally? Fasting as an essential regulator of immune responses

(2021) Christoph Wilhelm et al.   TRENDS IN IMMUNOLOGY

Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

(2021) José C. Páez-Franco et al.   Scientific Reports

Metabolic biomarker profiling for identification of susceptibility to severe pneumonia and COVID-19 in the general population

(2021) et al.   eLife

The Ability to Normalise Energy Metabolism in Advanced COVID-19 Disease Seems to Be One of the Key Factors Determining the Disease Progression—A Metabolomic NMR Study on Blood Plasma

(2021) Eva Baranovicova et al.   Applied Sciences-Basel

Could metabolomics drive the fate of COVID-19 pandemic? A narrative review on lights and shadows

(2021) Michele Mussap et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Integrative Modeling of Plasma Metabolic and Lipoprotein Biomarkers of SARS-CoV-2 Infection in Spanish and Australian COVID-19 Patient Cohorts

(2021) Reika Masuda et al.   JOURNAL OF PROTEOME RESEARCH

COVID-19 and Diabetes: Understanding the Interrelationship and Risks for a Severe Course

(2021) Cyril P. Landstra et al.   Frontiers in Endocrinology

Nuclear Magnetic Resonance Spectroscopy in Clinical Metabolomics and Personalized Medicine: Current Challenges and Perspectives

(2021) Marine P. M. Letertre et al.   Frontiers in Molecular Biosciences

Diagnostic Potential of the Plasma Lipidome in Infectious Disease: Application to Acute SARS-CoV-2 Infection

(2021) Nicola Gray et al.   Metabolites

SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells

(2021) Yogesh Singh et al.   Heliyon

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

(2021) Toshifumi Matsuyama et al.   CELL DEATH AND DIFFERENTIATION

Phenylalanine and COVID-19: Tracking disease severity markers

(2021) Rafael Luís Luporini et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Uneven metabolic and lipidomic profiles in recovered COVID‐19 patients as investigated by plasma NMR metabolomics

(2021) Maider Bizkarguenaga et al.   NMR IN BIOMEDICINE

Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients

(2021) Franziska Schmelter et al.   Frontiers in Molecular Biosciences

Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19

(2021) Gergana Taneva et al.   World Journal of Hepatology

Title: Human Serum/Plasma Glycoprotein Analysis by 1H-NMR, an Emerging Method of Inflammatory Assessment

(2020) Fuertes-Martín et al.   Journal of Clinical Medicine

Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis

(2020) Brandon Michael Henry et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Newly diagnosed diabetes is associated with a higher risk of mortality than known diabetes in hospitalized patients with COVID ‐19

(2020) Huiqing Li et al.   DIABETES OBESITY & METABOLISM

Hyperglycemia and the worse prognosis of COVID-19. Why a fast blood glucose control should be mandatory

(2020) Antonio Ceriello   DIABETES RESEARCH AND CLINICAL PRACTICE

COVID-19: Abnormal liver function tests

(2020) Qingxian Cai et al.   JOURNAL OF HEPATOLOGY

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

(2020) Bo Diao et al.   Frontiers in Immunology

Glycoprotein Profile Assessed by 1H-NMR as a Global Inflammation Marker in Patients with HIV Infection. A Prospective Study

(2020) Ana-Irene Malo et al.   Journal of Clinical Medicine

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

GlycA Levels during the Earliest Stages of Rheumatoid Arthritis: Potential Use as a Biomarker of Subclinical Cardiovascular Disease

(2020) Javier Rodríguez-Carrio et al.   Journal of Clinical Medicine

IL-6 and CD8+ T cell counts combined are an early predictor of in-hospital mortality of patients with COVID-19

(2020) Miao Luo et al.   JCI Insight

Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19

(2020) Chang Li et al.   Aging-US

Hyperglycemia is a strong predictor of poor prognosis in COVID-19

(2020) Sheng-ping Liu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis

(2020) Rubina Mulchandani et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Cytokine Levels in Critically Ill Patients With COVID-19 and Other Conditions

(2020) Matthijs Kox et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ferritin in the coronavirus disease 2019 (COVID‐19): A systematic review and meta‐analysis

(2020) Linlin Cheng et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Quantitative In-Vitro Diagnostic NMR Spectroscopy for Lipoprotein and Metabolite Measurements in Plasma and Serum: Recommendations for Analytical Artifact Minimization with Special Reference to COVID-19/SARS-CoV-2 Samples

(2020) Ruey Leng Loo et al.   JOURNAL OF PROTEOME RESEARCH

COVID-19: Proposing a Ketone-Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm

(2020) Patrick C. Bradshaw et al.   Oxidative Medicine and Cellular Longevity

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

(2020) Daniel E Leisman et al.   Lancet Respiratory Medicine

Hypertension, Diabetes and Obesity, Major Risk Factors for Death in Patients With COVID-19 in Mexico

(2020) Jorge Escobedo-de la Peña et al.   ARCHIVES OF MEDICAL RESEARCH

The key role of Warburg effect in SARS-CoV-2 replication and associated inflammatory response

(2020) Philippe Icard et al.   BIOCHIMIE

Blood molecular markers associated with COVID‐19 immunopathology and multi‐organ damage

(2020) Yan‐Mei Chen et al.   EMBO JOURNAL

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

(2020) Ioanna-Evdokia Galani et al.   NATURE IMMUNOLOGY

The effect of sampling procedures and day-to-day variations in metabolomics studies of biofluids

(2019) Guro F. Giskeødegård et al.   ANALYTICA CHIMICA ACTA

Glycoprotein A and B Height-to-Width Ratios as Obesity-Independent Novel Biomarkers of Low-Grade Chronic Inflammation in Women with Polycystic Ovary Syndrome (PCOS)

(2019) Rocío Fuertes-Martín et al.   JOURNAL OF PROTEOME RESEARCH

Interleukin 10 promotes macrophage uptake of HDL and LDL by stimulating fluid-phase endocytosis

(2019) Diego Lucero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Quantitative Lipoprotein Subclass and Low Molecular Weight Metabolite Analysis in Human Serum and Plasma by 1H NMR Spectroscopy in a Multilaboratory Trial

(2018) Beatriz Jiménez et al.   ANALYTICAL CHEMISTRY

Glycemic Control and Risk of Infections Among People With Type 1 or Type 2 Diabetes in a Large Primary Care Cohort Study

(2018) Julia A. Critchley et al.   DIABETES CARE

Consumption of regular-fat vs reduced-fat cheese reveals gender-specific changes in LDL particle size - a randomized controlled trial

(2018) Farinaz Raziani et al.   Nutrition & Metabolism

GlycA, a Nuclear Magnetic Resonance Spectroscopy Measure for Protein Glycosylation, is a Viable Biomarker for Disease Activity in IBD

(2018) Tim Dierckx et al.   Journal of Crohns & Colitis

Lipoprotein markers associated with disability from multiple sclerosis

(2018) A. R. Gafson et al.   Scientific Reports

Novel Applications of Metabolomics in Personalized Medicine: A Mini-Review

(2017) Bingbing Li et al.   MOLECULES

The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target

(2016) Icard Philippe et al.   DRUG RESISTANCE UPDATES

Emerging applications of metabolomics in drug discovery and precision medicine

(2016) David S. Wishart   NATURE REVIEWS DRUG DISCOVERY

The dual nature of HDL: Anti-Inflammatory and pro-Inflammatory

(2015) Ryan Namiri-Kalantari et al.   BIOFACTORS

GlycA: A Composite Nuclear Magnetic Resonance Biomarker of Systemic Inflammation

(2015) J. D. Otvos et al.   CLINICAL CHEMISTRY

Missing value imputation strategies for metabolomics data

(2015) Emily Grace Armitage et al.   ELECTROPHORESIS

A novel protein glycan biomarker and LCAT activity in metabolic syndrome

(2015) Eke G. Gruppen et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

GlycA is a Novel Marker of Inflammation Among Non-Critically Ill Hospitalized Patients with Type 2 Diabetes

(2015) Kathleen Dungan et al.   INFLAMMATION

GlycA, a novel marker of inflammation, is elevated in systemic lupus erythematosus

(2015) C P Chung et al.   LUPUS

The Biomarker GlycA Is Associated with Chronic Inflammation and Predicts Long-Term Risk of Severe Infection

(2015) Scott C. Ritchie et al.   Cell Systems

GlycA, a Pro-Inflammatory Glycoprotein Biomarker, and Incident Cardiovascular Disease: Relationship with C-Reactive Protein and Renal Function

(2015) Eke G. Gruppen et al.   PLoS One

Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons

(2014) Krista Fischer et al.   PLOS MEDICINE

Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio

(2013) Simon Geisler et al.   PTERIDINES

Glutamine and glutathione at ICU admission in relation to outcome

(2012) Paul Castillo Rodas et al.   CLINICAL SCIENCE

Effects of Inhibition of Interleukin-6 Signalling on Insulin Sensitivity and Lipoprotein (A) Levels in Human Subjects with Rheumatoid Diseases

(2010) Olaf Schultz et al.   PLoS One

MetaboAnalyst: a web server for metabolomic data analysis and interpretation

(2009) J. Xia et al.   NUCLEIC ACIDS RESEARCH

Serum phenylalanine concentrations in patients with ovarian carcinoma correlate with concentrations of immune activation markers and of isoprostane-8

(2008) Gabriele Neurauter et al.   CANCER LETTERS

Metabolic Phenotyping in Health and Disease

(2008) Elaine Holmes et al.   CELL