OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor microenvironment

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

(2021) Noella Lopes et al.   NATURE IMMUNOLOGY

Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity

(2021) Alexandra Schnell et al.   CELL

Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

(2020) Dominic G. Roy et al.   Cell Metabolism

Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells

(2020) Boyoung Shin et al.   Cell Reports

Cytokine-like Roles for Metabolites in Immunity

(2020) Zbigniew Zasłona et al.   MOLECULAR CELL

Multi-phenotype CRISPR-Cas9 Screen Identifies p38 Kinase as a Target for Adoptive Immunotherapies

(2020) Devikala Gurusamy et al.   CANCER CELL

IL-6 fuels durable memory for Th17 cell-mediated responses to tumors

(2020) Hannah M Knochelmann et al.   CANCER RESEARCH

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

(2019) Min Yuan et al.   Nature Protocols

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

(2019) Christopher J. Halbrook et al.   Cell Metabolism

Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function

(2019) Ulrike Kaufmann et al.   Cell Metabolism

The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

(2019) Sara Omenetti et al.   IMMUNITY

A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics

(2019) Ho-Joon Lee et al.   Metabolomics

Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection

(2019) Maria Carolina Amezcua Vesely et al.   CELL

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

(2019) Eric H. Ma et al.   IMMUNITY

Unraveling the Complex Interplay Between T Cell Metabolism and Function

(2018) Ramon I. Klein Geltink et al.   Annual Review of Immunology

Sorting cells alters their redox state and cellular metabolome

(2018) Elizabeth M. Llufrio et al.   Redox Biology

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

(2018) Gaojian Lian et al.   eLife

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

(2018) Peer W. F. Karmaus et al.   NATURE

Glutathione Primes T Cell Metabolism for Inflammation

(2017) Tak W. Mak et al.   IMMUNITY

Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis

(2017) Luigi Franchi et al.   JOURNAL OF IMMUNOLOGY

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

(2017) Tao Xu et al.   NATURE

Intratumoral CD8 + T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity

(2017) Brendan L. Horton et al.   Cancer Immunology Research

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

(2016) Michael D. Buck et al.   CELL

Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy

(2016) Madhusudhanan Sukumar et al.   Cell Metabolism

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

(2016) Thomas G. McWilliams et al.   JOURNAL OF CELL BIOLOGY

Sensitivity to Restimulation-Induced Cell Death Is Linked to Glycolytic Metabolism in Human T Cells

(2016) Sasha E. Larsen et al.   JOURNAL OF IMMUNOLOGY

Emerging concepts of T cell metabolism as a target of immunotherapy

(2016) Chih-Hao Chang et al.   NATURE IMMUNOLOGY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

(2013) Madhusudhanan Sukumar et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

(2013) G. J. W. van der Windt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dissecting T Cell Contraction In Vivo Using a Genetically Encoded Reporter of Apoptosis

(2012) Kym R. Garrod et al.   Cell Reports

Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

(2011) Pawel Muranski et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human TH17 Cells Are Long-Lived Effector Memory Cells

(2011) I. Kryczek et al.   Science Translational Medicine

T Helper 17 Cells Promote Cytotoxic T Cell Activation in Tumor Immunity

(2009) Natalia Martin-Orozco et al.   IMMUNITY

Unlike Th1, Th17 Cells Mediate Sustained Autoimmune Inflammation and Are Highly Resistant to Restimulation-Induced Cell Death

(2009) G. Shi et al.   JOURNAL OF IMMUNOLOGY

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY