Biological Features of Nanoparticles: Protein Corona Formation and Interaction with the Immune System

Nanoparticles Surface Chemistry Influence on Protein Corona Composition and Inflammatory Responses

(2022) Laura E. González-García et al.   Nanomaterials

Temperature, concentration, and surface modification influence the cellular uptake and the protein corona of polystyrene nanoparticles

(2022) J. Oberländer et al.   Acta Biomaterialia

Block Length‐Dependent Protein Fouling on Poly(2‐oxazoline)‐Based Polymersomes: Influence on Macrophage Association and Circulation Behavior

(2022) Adrian Najer et al.   Small

Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein A-I in corona formation

(2022) Mingyang Li et al.   Nature Communications

Plasminogen activator-coated nanobubbles targeting cell-bound β2-glycoprotein I as a novel thrombus-specific thrombolytic strategy

(2022) Paolo Macor et al.   HAEMATOLOGICA

Nanocarriers as a Delivery Platform for Anticancer Treatment: Biological Limits and Perspectives in B-Cell Malignancies

(2022) Sara Bozzer et al.   Pharmaceutics

Zebrafish: A Useful Animal Model for the Characterization of Drug-Loaded Polymeric NPs

(2022) Sara Bozzer et al.   Biomedicines

Complement-Opsonized Nano-Carriers Are Bound by Dendritic Cells (DC) via Complement Receptor (CR)3, and by B Cell Subpopulations via CR-1/2, and Affect the Activation of DC and B-1 Cells

(2021) Monika Bednarczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unfolded Protein Corona Surrounding Nanotubes Influence the Innate and Adaptive Immune System

(2021) Jun‐Young Park et al.   Advanced Science

The protein corona and its effects on nanoparticle-based drug delivery systems

(2021) Hanmei Li et al.   Acta Biomaterialia

Advances in Biomimetic Nanoparticles for Targeted Cancer Therapy and Diagnosis

(2021) Chaw Yee Beh et al.   MOLECULES

Evolution of the protein corona affects macrophage polarization

(2021) Huayan Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Temperature‐Responsive Nanoparticles Enable Specific Binding of Apolipoproteins from Human Plasma

(2021) Mongkhol Prawatborisut et al.   Small

The Interactions between Nanoparticles and the Innate Immune System from a Nanotechnologist Perspective

(2021) Lena Ernst et al.   Nanomaterials

Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles

(2020) Tânia Lima et al.   Scientific Reports

Protein Corona Composition of Silica Nanoparticles in Complex Media: Nanoparticle Size does not Matter

(2020) Laurent Marichal et al.   Nanomaterials

The Dual Role of the Liver in Nanomedicine as an Actor in the Elimination of Nanostructures or a Therapeutic Target

(2020) Lorena Baboci et al.   Journal of Oncology

Human plasma protein adsorption to elastin-like polypeptide nanoparticles

(2020) Markian S. Bahniuk et al.   Biointerphases

Immunoglobulins on the surface of differently charged polymer nanoparticles

(2020) Domenik Prozeller et al.   Biointerphases

Stealth Coating of Nanoparticles in Drug-Delivery Systems

(2020) See Yee Fam et al.   Nanomaterials

Challenges in nanomedicine clinical translation

(2020) Josbert M. Metselaar et al.   Drug Delivery and Translational Research

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

(2020) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Identification of a Profile of Neutrophil-Derived Granule Proteins in the Surface of Gold Nanoparticles after Their Interaction with Human Breast Cancer Sera

(2020) María del Pilar Chantada-Vázquez et al.   Nanomaterials

Interrogation of Folic Acid-Functionalized Nanomedicines: The Regulatory Roles of Plasma Proteins Reexamined

(2020) Huan Wang et al.   ACS Nano

Polymer-coated nanoparticle protein corona formation potentiates phagocytosis of bacteria by innate immune cells and inhibits coagulation in human plasma

(2020) Van A. Ortega et al.   Biointerphases

Opsonins and Dysopsonins of Nanoparticles: Facts, Concepts, and Methodological Guidelines

(2020) Emanuele Papini et al.   Frontiers in Immunology

The influence of shape and charge on protein corona composition in common gold nanostructures

(2020) Tony Bewersdorff et al.   Materials Science & Engineering C-Materials for Biological Applications

Engineering precision nanoparticles for drug delivery

(2020) Michael J. Mitchell et al.   NATURE REVIEWS DRUG DISCOVERY

Nanomedicines accessible in the market for clinical interventions

(2020) Vedant Gadekar et al.   JOURNAL OF CONTROLLED RELEASE

Impact of particle size and pH on protein corona formation of solid lipid nanoparticles: A proof-of-concept study

(2020) Wenhao Wang et al.   Acta Pharmaceutica Sinica B

Soft and Hard Interactions between Polystyrene Nanoplastics and Human Serum Albumin Protein Corona

(2019) Shinji Kihara et al.   BIOCONJUGATE CHEMISTRY

Link between Low-Fouling and Stealth: A Whole Blood Biomolecular Corona and Cellular Association Analysis on Nanoengineered Particles

(2019) Alessia C. G. Weiss et al.   ACS Nano

Formation of a Monolayer Protein Corona around Polystyrene Nanoparticles and Implications for Nanoparticle Agglomeration

(2019) Haixia Wang et al.   Small

Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles

(2019) Katrin Partikel et al.   Beilstein Journal of Nanotechnology

Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

(2019) Yi Wang et al.   Advanced Science

The effect of salts in aqueous media on the formation of the BSA corona on SiO2 nanoparticles

(2019) Brittany E. Givens et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Targeting CD34+ cells of the inflamed synovial endothelium by guided nanoparticles for the treatment of rheumatoid arthritis

(2019) Federico Colombo et al.   JOURNAL OF AUTOIMMUNITY

Nano-bio interactions: a neutrophil-centric view

(2019) Sandeep Keshavan et al.   Cell Death & Disease

Protein Adsorption: A Feasible Method for Nanoparticle Functionalization?

(2019) Roberta Cagliani et al.   Materials

Amphiphilic nanogels: influence of surface hydrophobicity on protein corona, biocompatibility and cellular uptake

(2019) Tony Bewersdorff et al.   International Journal of Nanomedicine

Tailoring the component of protein corona via simple chemistry

(2019) Xiang Lu et al.   Nature Communications

Corona of Thorns: The Surface Chemistry-Mediated Protein Corona Perturbs the Recognition and Immune Response of Macrophages

(2019) Rong Cai et al.   ACS Applied Materials & Interfaces

Formation of Protein Corona on Nanoparticle Affects Different Complement Activation Pathways Mediated by C1q

(2019) Tingting Ding et al.   PHARMACEUTICAL RESEARCH

Differential Recognition of Nanoparticle Protein Corona and Modified Low-Density Lipoprotein by Macrophage Receptor with Collagenous Structure

(2018) Sandra Lara et al.   ACS Nano

C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes

(2018) Regina Tavano et al.   ACS Nano

Microfluidic Examination of the “Hard” Biomolecular Corona Formed on Engineered Particles in Different Biological Milieu

(2018) Alessia C. G. Weiss et al.   BIOMACROMOLECULES

The Transferability from Animal Models to Humans: Challenges Regarding Aggregation and Protein Corona Formation of Nanoparticles

(2018) Laura K. Müller et al.   BIOMACROMOLECULES

In vitro assessment of silver nanoparticles immunotoxicity

(2018) Valentina Galbiati et al.   FOOD AND CHEMICAL TOXICOLOGY

Protein corona–mediated targeting of nanocarriers to B cells allows redirection of allergic immune responses

(2018) Limei Shen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vivo formation of protein corona on gold nanoparticles. The effect of their size and shape

(2018) Rafaela García-Álvarez et al.   Nanoscale

Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona

(2018) Manuel Tonigold et al.   Nature Nanotechnology

Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona

(2018) Jianbin Mo et al.   Nature Communications

Adsorption of Plasma Proteins on Single-Walled Carbon Nanotubes Reduced Cytotoxicity and Modulated Neutrophil Activation

(2018) Naihao Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Anti-polyethylene glycol antibodies alter the protein corona deposited on nanoparticles and the physiological pathways regulating their fate in vivo

(2018) Philippe Grenier et al.   JOURNAL OF CONTROLLED RELEASE

Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions

(2018) Johanna Simon et al.   Nanoscale

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

Complement as a Biological Tool to Control Tumor Growth

(2018) Paolo Macor et al.   Frontiers in Immunology

Protein Corona Formed from Different Blood Plasma Proteins Affects the Colloidal Stability of Nanoparticles Differently

(2018) Yan Teck Ho et al.   BIOCONJUGATE CHEMISTRY

Immunoglobulin deposition on biomolecule corona determines complement opsonization efficiency of preclinical and clinical nanoparticles

(2018) Vivian P. Vu et al.   Nature Nanotechnology

Cloaking nanoparticles with protein corona shield for targeted drug delivery

(2018) Jun Yong Oh et al.   Nature Communications

Inorganic nanoparticles as potential regulators of immune response in dendritic cells

(2017) Silvia Fogli et al.   Nanomedicine

Pulmonary surfactant protein SP-D opsonises carbon nanotubes and augments their phagocytosis and subsequent pro-inflammatory immune response

(2017) Kirsten M. Pondman et al.   Nanoscale

Personalized protein corona on nanoparticles and its clinical implications

(2017) Claudia Corbo et al.   Biomaterials Science

Probing fibronectin conformation on a protein corona layer around nanoparticles

(2017) Mohammad Raoufi et al.   Nanoscale

Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona

(2016) Krishnendu Saha et al.   ACS Nano

Liposomes Coated with Isolated Macrophage Membrane Can Target Lung Metastasis of Breast Cancer

(2016) Haiqiang Cao et al.   ACS Nano

Clusterin in the protein corona plays a key role in the stealth effect of nanoparticles against phagocytes

(2016) Michihiko Aoyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modification of the protein corona–nanoparticle complex by physiological factors

(2016) Nicholas J. Braun et al.   Materials Science & Engineering C-Materials for Biological Applications

Pulmonary Surfactant Protein A-Mediated Enrichment of Surface-Decorated Polymeric Nanoparticles in Alveolar Macrophages

(2016) Christian A. Ruge et al.   MOLECULAR PHARMACEUTICS

Differential uptake of nanoparticles by human M1 and M2 polarized macrophages: protein corona as a critical determinant

(2016) Karin A Binnemars-Postma et al.   Nanomedicine

Adsorbed plasma proteins modulate the effects of single-walled carbon nanotubes on neutrophils in blood

(2016) Irina I. Vlasova et al.   Nanomedicine-Nanotechnology Biology and Medicine

Time-evolution of in vivo protein corona onto blood-circulating PEGylated liposomal doxorubicin (DOXIL) nanoparticles

(2016) Marilena Hadjidemetriou et al.   Nanoscale

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers

(2016) Susanne Schöttler et al.   Nature Nanotechnology

Protein Adsorption From Biofluids on Silica Nanoparticles: Corona Analysis as a Function of Particle Diameter and Porosity

(2015) Alden M. Clemments et al.   ACS Applied Materials & Interfaces

Gold Nanoparticle-Enabled Blood Test for Early Stage Cancer Detection and Risk Assessment

(2015) Tianyu Zheng et al.   ACS Applied Materials & Interfaces

TiO 2 nanoparticles tested in a novel screening whole human blood model of toxicity trigger adverse activation of the kallikrein system at low concentrations

(2015) Barbro Ekstrand-Hammarström et al.   BIOMATERIALS

Nanoparticle uptake: The phagocyte problem

(2015) Heather Herd Gustafson et al.   Nano Today

The functional dissection of the plasma corona of SiO2-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages

(2015) Chiara Fedeli et al.   Nanoscale

Surfactant protein A (SP-A) inhibits agglomeration and macrophage uptake of toxic amine modified nanoparticles

(2015) Zofi McKenzie et al.   Nanotoxicology

The Cost of Drug Development

(2015) Joseph A. DiMasi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteomics Analysis Reveals Distinct Corona Composition on Magnetic Nanoparticles with Different Surface Coatings: Implications for Interactions with Primary Human Macrophages

(2015) Carmen Vogt et al.   PLoS One

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

(2014) Lara K. Bogart et al.   ACS Nano

Cryptic Epitopes of Albumin Determine Mononuclear Phagocyte System Clearance of Nanomaterials

(2014) Gysell M. Mortimer et al.   ACS Nano

Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles

(2014) Yvonne Klapper et al.   BIOMATERIALS

Nanoparticle size matters in the formation of plasma protein coronas on Fe3O4 nanoparticles

(2014) Zhengyan Hu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Phagocytosis: receptors, signal integration, and the cytoskeleton

(2014) Spencer A. Freeman et al.   IMMUNOLOGICAL REVIEWS

Variations of the corona HDL:albumin ratio determine distinct effects of amorphous SiO2 nanoparticles on monocytes and macrophages in serum

(2014) Chiara Fedeli et al.   Nanomedicine

Personalized protein coronas: a “key” factor at the nanobiointerface

(2014) Mohammad J. Hajipour et al.   Biomaterials Science

Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines

(2013) Yan Yan et al.   ACS Nano

Protein corona significantly reduces active targeting yield

(2013) Vahid Mirshafiee et al.   CHEMICAL COMMUNICATIONS

Nanoparticle clearance is governed by Th1/Th2 immunity and strain background

(2013) Stephen W. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Poly(2-oxazoline)s as materials for biomedical applications

(2013) Victor R. de la Rosa   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release

(2013) Santosh Aryal et al.   Nanomedicine

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Surface Charge Switchable Nanoparticles Based on Zwitterionic Polymer for Enhanced Drug Delivery to Tumor

(2012) You-Yong Yuan et al.   ADVANCED MATERIALS

Tailoring the immune response by targeting C-type lectin receptors on alveolar macrophages using “pathogen-like” amphiphilic polyanhydride nanoparticles

(2012) Ana V. Chavez-Santoscoy et al.   BIOMATERIALS

The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy

(2012) Tennyson L. Doane et al.   CHEMICAL SOCIETY REVIEWS

Super-hydrophilic zwitterionic poly(carboxybetaine) and amphiphilic non-ionic poly(ethylene glycol) for stealth nanoparticles

(2012) Zhiqiang Cao et al.   Nano Today

Surfactant protein D (SP-D) alters cellular uptake of particles and nanoparticles

(2012) Michaela Kendall et al.   Nanotoxicology

Differential Uptake of Functionalized Polystyrene Nanoparticles by Human Macrophages and a Monocytic Cell Line

(2011) Oleg Lunov et al.   ACS Nano

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS

Regulators of macrophage activation

(2011) Fernando O. Martinez   EUROPEAN JOURNAL OF IMMUNOLOGY

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

(2011) Christian A. Ruge et al.   Nanomedicine-Nanotechnology Biology and Medicine

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Ultralow-Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications

(2009) Shaoyi Jiang et al.   ADVANCED MATERIALS

Complement in human diseases: Lessons from complement deficiencies

(2009) Marina Botto et al.   MOLECULAR IMMUNOLOGY

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY