Oral Macrocystis pyrifera Fucoidan Administration Exhibits Anti-Inflammatory and Antioxidant Properties and Improves DSS-Induced Colitis in C57BL/6J Mice

Immunity and Nutrition: The Right Balance in Inflammatory Bowel Disease

(2022) Bartolo Tamburini et al.   Cells

Superoxide Radicals in the Execution of Cell Death

(2022) Junichi Fujii et al.   Antioxidants

Characteristics and Antioxidant Activity of Fucoidan from Sargassum hystrix: Effect of Extraction Method

(2022) Amir Husni et al.   International Journal of Food Science

Inhibition of the Occurrence and Development of Inflammation-Related Colorectal Cancer by Fucoidan Extracted from Sargassum fusiforme

(2022) Xiang Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Oxidative Stress in the Pathogenesis of Crohn’s Disease and the Interconnection with Immunological Response, Microbiota, External Environmental Factors, and Epigenetics

(2021) Ester Alemany-Cosme et al.   Antioxidants

Extensive Histopathological Characterization of Inflamed Bowel in the Dextran Sulfate Sodium Mouse Model with Emphasis on Clinically Relevant Biomarkers and Targets for Drug Development

(2021) Rita Bonfiglio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

6-Gingerol, a Bioactive Compound of Ginger Attenuates Renal Damage in Streptozotocin-Induced Diabetic Rats by Regulating the Oxidative Stress and Inflammation

(2021) Saleh A. Almatroodi et al.   Pharmaceutics

The Impact of Oxidative Stress in Human Pathology: Focus on Gastrointestinal Disorders

(2021) Rosa Vona et al.   Antioxidants

Role of Oxidative Stress and Inflammatory Cytokines (TNF-α and IL-6) in Acetic Acid-Induced Ulcerative Colitis in Rats: Ameliorated by Otostegia fruticosa

(2021) Mohd Nazam Ansari et al.   Life-Basel

Oxyresveratrol Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats by Suppressing Inflammation

(2021) Jiah Yeom et al.   MOLECULES

Asperuloside Enhances Taste Perception and Prevents Weight Gain in High-Fat Fed Mice

(2021) Muhammad Ishaq et al.   Frontiers in Endocrinology

Role of IL-6 in the commitment of T cell subsets

(2021) Thomas Korn et al.   CYTOKINE

Anti-Inflammatory Activity of Fucoidan Extracts In Vitro

(2021) Tauseef Ahmad et al.   Marine Drugs

Risk Factors for Malnutrition among IBD Patients

(2021) Larisa Einav et al.   Nutrients

Role of Eosinophils in Intestinal Inflammation and Fibrosis in Inflammatory Bowel Disease: An Overlooked Villain?

(2021) Inge Jacobs et al.   Frontiers in Immunology

Idebenone Protects against Acute Murine Colitis via Antioxidant and Anti-Inflammatory Mechanisms

(2020) Sonia Shastri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress and Redox-Modulating Therapeutics in Inflammatory Bowel Disease

(2020) Arno R. Bourgonje et al.   TRENDS IN MOLECULAR MEDICINE

Review: Local Tumor Necrosis Factor-α Inhibition in Inflammatory Bowel Disease

(2020) Bahez Gareb et al.   Pharmaceutics

New insights in intestinal oxidative stress damage and the health intervention effects of nutrients: A review

(2020) Yajie Wang et al.   Journal of Functional Foods

The Cost of Inflammatory Bowel Disease: An Initiative From the Crohn’s & Colitis Foundation

(2019) K T Park et al.   INFLAMMATORY BOWEL DISEASES

Synbiotic Supplementation Containing Whole Plant Sugar Cane Fibre and Probiotic Spores Potentiates Protective Synergistic Effects in Mouse Model of IBD

(2019) Tanvi Shinde et al.   Nutrients

IFN-γ drives inflammatory bowel disease pathogenesis through VE-cadherin–directed vascular barrier disruption

(2019) Victoria Langer et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

(2019) Ankita Nandi et al.   Oxidative Medicine and Cellular Longevity

Remarkable Protective Effects of Nrf2-Mediated Antioxidant Enzymes and Tissue Specificity in Different Skeletal Muscles of Daurian Ground Squirrels Over the Torpor-Arousal Cycle

(2019) Yanhong Wei et al.   Frontiers in Physiology

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

(2019) Sujuan Ding et al.   Biomolecules

Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease

(2018) Belal Chami et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Synergistic effect of interleukin-17 and tumour necrosis factor-α on inflammatory response in hepatocytes through interleukin-6-dependent and independent pathways

(2018) A. Beringer et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Superoxide dismutases: Dual roles in controlling ROS damage and regulating ROS signaling

(2018) Ying Wang et al.   JOURNAL OF CELL BIOLOGY

Development of Reliable, Valid and Responsive Scoring Systems for Endoscopy and Histology in Animal Models for Inflammatory Bowel Disease

(2018) Pim J Koelink et al.   Journal of Crohns & Colitis

Berberrubine attenuates mucosal lesions and inflammation in dextran sodium sulfate-induced colitis in mice

(2018) Xiu-Ting Yu et al.   PLoS One

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

(2018) Tiantian Wang et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Fucoidan Alleviates Acetaminophen-Induced Hepatotoxicity via Oxidative Stress Inhibition and Nrf2 Translocation

(2018) Yu-qin Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3-Dependent and -Independent Processing of Interleukin (IL)-1β in Active Ulcerative Colitis

(2018) Nicole Ranson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic and environmental factors drive personalized medicine for Crohn’s disease

(2018) Shigeru Oshima et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of Regulation of the Chemokine-Receptor Network

(2017) Martin Stone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nrf2, the Master Regulator of Anti-Oxidative Responses

(2017) Sandra Vomund et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prevalence of Malnutrition and Nutritional Characteristics of Patients With Inflammatory Bowel Disease

(2017) María José Casanova et al.   Journal of Crohns & Colitis

Crohn's disease

(2017) Joana Torres et al.   LANCET

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

In vitro and in vivo anti-primary effusion lymphoma activities of fucoidan extracted from Cladosiphon okamuranus Tokida

(2017) Chie Ishikawa et al.   ONCOLOGY REPORTS

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

(2017) Tian Tian et al.   Oxidative Medicine and Cellular Longevity

Systemic interleukin-9 in inflammatory bowel disease: Association with mucosal healing in ulcerative colitis

(2017) Malgorzata Matusiewicz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis

(2017) Derrick D Eichele et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice

(2017) Manish Kumar Jeengar et al.   Scientific Reports

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

(2016) G Aviello et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of chemokine receptors and intestinal epithelial cells in the mucosal inflammation and tolerance

(2016) Neeraja Kulkarni et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Anti-inflammatory Actions of (+)-3′α-Angeloxy-4′-keto-3′,4′-dihydroseselin (Pd-Ib) against Dextran Sulfate Sodium-Induced Colitis in C57BL/6 Mice

(2016) Huai-Xue Mu et al.   JOURNAL OF NATURAL PRODUCTS

Fucoidan reduces oxidative stress by regulating the gene expression of HO-1 and SOD-1 through the Nrf2/ERK signaling pathway in HaCaT cells

(2016) Min Ju Ryu et al.   Molecular Medicine Reports

Healing enhancement of diabetic wounds by locally infiltrated epidermal growth factor is associated with systemic oxidative stress reduction

(2016) Ariana García Ojalvo et al.   International Wound Journal

The implications of oxidative stress and antioxidant therapies in Inflammatory Bowel Disease: Clinical aspects and animal models

(2016) IoanaMiruna Balmus et al.   Saudi Journal of Gastroenterology

Significance of serum Il-9 levels in inflammatory bowel disease

(2015) Caterina Defendenti et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation

(2015) Sadiq Umar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis

(2015) Italia Loddo et al.   Frontiers in Immunology

Fucoidan Extracts Ameliorate Acute Colitis

(2015) Qi Ying Lean et al.   PLoS One

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

Effects of dietary fucoidan on the blood constituents, anti-oxidation and innate immunity of juvenile yellow catfish (Pelteobagrus fulvidraco)

(2014) Qing Yang et al.   FISH & SHELLFISH IMMUNOLOGY

A Review on Chemical-Induced Inflammatory Bowel Disease Models in Rodents

(2014) Puneet Kaur Randhawa et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

(2014) Asima Bhattacharyya et al.   PHYSIOLOGICAL REVIEWS

Bifidobacterium breve Attenuates Murine Dextran Sodium Sulfate-Induced Colitis and Increases Regulatory T Cell Responses

(2014) Bin Zheng et al.   PLoS One

Master regulator of intestinal disease: IL-6 in chronic inflammation and cancer development

(2014) Maximilian J. Waldner et al.   SEMINARS IN IMMUNOLOGY

Inflammatory Bowel Disease: Mechanisms, Redox Considerations, and Therapeutic Targets

(2013) Fiorella Biasi et al.   ANTIOXIDANTS & REDOX SIGNALING

Innate and adaptive immunity in inflammatory bowel disease

(2013) Alessandra Geremia et al.   AUTOIMMUNITY REVIEWS

Preparation of low molecular weight fucoidan by gamma-irradiation and its anticancer activity

(2013) Jong-il Choi et al.   CARBOHYDRATE POLYMERS

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

(2013) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family

(2013) Hyun Park et al.   Marine Drugs

Changes of the cytokine profile in inflammatory bowel diseases

(2012) Györgyi Műzes   WORLD JOURNAL OF GASTROENTEROLOGY

Chronic intestinal inflammation: inflammatory bowel disease and colitis-associated colon cancer

(2012) Deborah C. Rubin et al.   Frontiers in Immunology

Fucoidan, a sulfated polysaccharide from brown algae, against myocardial ischemia–reperfusion injury in rats via regulating the inflammation response

(2011) Chunmei Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus 
type-1-associated neurological disease

(2010) Natsumi Araya et al.   ANTIVIRAL THERAPY

Adverse effects of biologics used for treating IBD

(2010) Andreas Stallmach et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

(2010) H.-C. REINECKER et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Proinflammatory cytokines underlying the inflammation of Crohnʼs disease

(2010) Warren Strober et al.   CURRENT OPINION IN GASTROENTEROLOGY

Combination of thiopurines and allopurinol: Adverse events and clinical benefit in IBD

(2010) Shail M. Govani et al.   Journal of Crohns & Colitis

Nrf2-dependent upregulation of antioxidative enzymes: a novel pathway for proteasome inhibitor-mediated cardioprotection

(2009) H. Dreger et al.   CARDIOVASCULAR RESEARCH

Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia

(2009) Yan-Qiu Cui et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Fucoidan protects against dopaminergic neuron death in vivo and in vitro

(2009) Dingzhen Luo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The role of macrophages in inflammatory bowel diseases

(2009) Sigrid E.M. Heinsbroek et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Suppression of iNOS expression by fucoidan is mediated by regulation of p38 MAPK, JAK/STAT, AP-1 and IRF-1, and depends on up-regulation of scavenger receptor B1 expression in TNF-α- and IFN-γ-stimulated C6 glioma cells☆

(2009) Hang Do et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

(2009) Laurent Beaugerie et al.   LANCET

Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities

(2008) F. Eddahri et al.   BLOOD

Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease

(2008) Noah P. Zimmerman et al.   INFLAMMATORY BOWEL DISEASES

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

Role of cytokines in inflammatory bowel disease

(2008) Fausto Sanchez-Muñoz et al.   WORLD JOURNAL OF GASTROENTEROLOGY