UBA52 Is Crucial in HSP90 Ubiquitylation and Neurodegenerative Signaling during Early Phase of Parkinson’s Disease

Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer’s disease

(2022) Abhishek Singh et al.   CELL AND TISSUE RESEARCH

Cdk5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson’s disease

(2022) Jianguo Yan et al.   npj Parkinsons Disease

4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson’s Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation

(2022) Shubhangini Tiwari et al.   NEUROCHEMICAL RESEARCH

Cardinal role of eukaryotic initiation factor 2 (eIF2α) in progressive dopaminergic neuronal death & DNA fragmentation: Implication of PERK:IRE1α:ATF6 axis in Parkinson's pathology

(2021) Sonam Gupta et al.   CELLULAR SIGNALLING

Rivastigmine attenuates the Alzheimer's disease related protein degradation and apoptotic neuronal death signaling

(2021) Parul Gupta et al.   BIOCHEMICAL JOURNAL

Clinical significance of UbA52 level in the urine of patients with type 2 diabetes mellitus and diabetic kidney disease

(2021) Xiaochang Xu et al.   NEFROLOGIA

Mechanism for antiParkinsonian effect of resveratrol: Involvement of transporters, synaptic proteins, dendrite arborization, biochemical alterations, ER stress and apoptosis

(2021) Ashish Singh et al.   FOOD AND CHEMICAL TOXICOLOGY

Endoplasmic Reticulum Stress Regulators: New Drug Targets for Parkinson’s Disease

(2021) Vera Kovaleva et al.   Journal of Parkinsons Disease

Reciprocal Upshot of Nitric Oxide, Endoplasmic Reticulum Stress, and Ubiquitin Proteasome System in Parkinson’s Disease Pathology

(2020) Shubhangini Tiwari et al.   NEUROSCIENTIST

Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson’s disease

(2020) Alysia Ross et al.   Molecular Brain

Reductive stress promotes protein aggregation and impairs neurogenesis

(2020) Kishore Kumar S Narasimhan et al.   Redox Biology

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation

(2020) Kaushik Bhattacharya et al.   Nature Communications

The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson’s Disease Physiopathology

(2020) Cristine Alves da Costa et al.   Cells

Regulation of α-synuclein by chaperones in mammalian cells

(2019) Björn M. Burmann et al.   NATURE

New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis

(2018) Dinesh Kumar Verma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

(2018) Asad Jan et al.   Acta Neuropathologica Communications

Ubiquitination of alpha-synuclein filaments by Nedd4 ligases

(2018) Thomas Mund et al.   PLoS One

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

Chaperone-Based Therapies for Disease Modification in Parkinson’s Disease

(2017) Erik L. Friesen et al.   Parkinsons Disease

The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development

(2016) Masanori Kobayashi et al.   Scientific Reports

Endoplasmic Reticulum Stress Instigates the Rotenone Induced Oxidative Apoptotic Neuronal Death: a Study in Rat Brain

(2015) Poonam Goswami et al.   MOLECULAR NEUROBIOLOGY

6-Hydroxydopamine and lipopolysaccharides induced DNA damage in astrocytes: Involvement of nitric oxide and mitochondria

(2015) Sonam Gupta et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

(2015) Katrina L. Paumier et al.   NEUROBIOLOGY OF DISEASE

Homology-based prediction of interactions between proteins using Averaged One-Dependence Estimators

(2014) Yoichi Murakami et al.   BMC BIOINFORMATICS

A model in which heat shock protein 90 targets protein-folding clefts: Rationale for a new approach to neuroprotective treatment of protein folding diseases

(2014) William B Pratt et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Regulated protein turnover: snapshots of the proteasome in action

(2014) Sucharita Bhattacharyya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

(2014) Zoi Erpapazoglou et al.   Cells

Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment

(2014) Dong-Ik Shin et al.   Experimental Neurobiology

Protein degradation pathways in Parkinson’s disease: curse or blessing

(2012) Darius Ebrahimi-Fakhari et al.   ACTA NEUROPATHOLOGICA

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Yeast Ribosomal Protein L40 Assembles Late into Precursor 60 S Ribosomes and Is Required for Their Cytoplasmic Maturation

(2012) Antonio Fernández-Pevida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Dynamic Interaction of Hsp90 with Its Client Protein p53

(2011) Sung Jean Park et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation of Distinct Ubiquitin Chain Reagents of High Purity and Yield

(2011) Ken C. Dong et al.   STRUCTURE

K63-linked ubiquitination and neurodegeneration

(2010) Kah-Leong Lim et al.   NEUROBIOLOGY OF DISEASE

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Identification of Residues on Hsp70 and Hsp90 Ubiquitinated by the Cochaperone CHIP

(2009) Lenka Kundrat et al.   JOURNAL OF MOLECULAR BIOLOGY

Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology

(2008) Filip Simunovic et al.   BRAIN

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

(2008) M Kathleen Borland et al.   Molecular Neurodegeneration

Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction

(2008) Hwan-Ching Tai et al.   NATURE REVIEWS NEUROSCIENCE

Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research

(2008) Yuen-Ting Cheung et al.   NEUROTOXICOLOGY

In vivo alpha-synuclein overexpression in rodents: A useful model of Parkinson's disease?

(2007) Marie-Francoise Chesselet   EXPERIMENTAL NEUROLOGY