Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

(2017) Jonathan Arias-Fuenzalida et al.   Stem Cell Reports

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response

(2016) Asad Jan et al.   ACTA NEUROPATHOLOGICA

Translating the anticancer properties of eEF2K

(2016) Aude De Gassart et al.   CELL CYCLE

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences

(2016) Afshan N. Malik et al.   MITOCHONDRION

Pharyngeal pumping in Caenorhabditis elegans depends on tonic and phasic signaling from the nervous system

(2016) Nicholas F. Trojanowski et al.   Scientific Reports

Nrf2—a therapeutic target for the treatment of neurodegenerative diseases

(2015) Delinda A. Johnson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dynamics of Elongation Factor 2 Kinase Regulation in Cortical Neurons in Response to Synaptic Activity

(2015) J. W. Kenney et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons

(2015) A K Reeve et al.   Cell Death & Disease

A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS

(2015) Theo Hatzipetros et al.   Jove-Journal of Visualized Experiments

The Brainstem Pathologies of Parkinson's Disease and Dementia with Lewy Bodies

(2014) Kay Seidel et al.   BRAIN PATHOLOGY

Germline Quality Control: eEF2K Stands Guard to Eliminate Defective Oocytes

(2014) Hsueh-Ping Chu et al.   DEVELOPMENTAL CELL

Inhibition of AMP-Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid  

(2014) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons

(2014) Christopher Heise et al.   Frontiers in Cellular Neuroscience

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation

(2013) Marthe H. R. Ludtmann et al.   BIOCHEMICAL JOURNAL

The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation

(2013) Gabriel Leprivier et al.   CELL

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

(ADP-ribose) polymerase 1 and AMP-activated protein kinase mediate progressive dopaminergic neuronal degeneration in a mouse model of Parkinson’s disease

(2013) T W Kim et al.   Cell Death & Disease

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

(2012) Yoichiro Mitsuishi et al.   CANCER CELL

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

AMP Kinase Activation Mitigates Dopaminergic Dysfunction and Mitochondrial Abnormalities in Drosophila Models of Parkinson's Disease

(2012) C.-H. Ng et al.   JOURNAL OF NEUROSCIENCE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

Adenosine monophosphate-activated protein kinase overactivation leads to accumulation of α-synuclein oligomers and decrease of neurites

(2012) Peizhou Jiang et al.   NEUROBIOLOGY OF AGING

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo

(2010) Shankar J. Chinta et al.   NEUROSCIENCE LETTERS

AMP-activated protein kinase is activated in Parkinson’s disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

(2009) Jae-Sun Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ethanol preference inC. elegans

(2009) J. Lee et al.   GENES BRAIN AND BEHAVIOR

Differentiation of mouse Neuro 2A cells into dopamine neurons

(2009) Roger G. Tremblay et al.   JOURNAL OF NEUROSCIENCE METHODS

A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death

(2008) M Boyce et al.   CELL DEATH AND DIFFERENTIATION

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

(2008) Anthony HV Schapira   LANCET NEUROLOGY