Article
Cell Biology
Sonam Gupta, Amit Mishra, Sarika Singh
Summary: The study demonstrated that salubrinal provided significant protection against rotenone-induced adverse effects on dopaminergic neurons, suggesting its potential therapeutic utility in Parkinson's disease by attenuating progressive neuronal death and pathological alterations.
CELLULAR SIGNALLING
(2021)
Article
Neurosciences
Wen Lu, Kun Ni, Zhuangzhuang Li, Lili Xiao, Yini Li, Yumeng Jiang, Jincheng Zhang, Haibo Shi
Summary: This study revealed that salubrinal, a dephosphorylation inhibitor of eIF2 alpha signaling, can protect against cisplatin-induced damage in cochlear cells by attenuating endoplasmic reticulum stress. These findings suggest that pharmacological inhibition of eIF2 alpha-mediated ERS could be a potential treatment for cisplatin-induced ototoxicity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biology
Xinfu Fan, Jie Chen, Zongmeng Zhang, Fanghui Chen, Haosen Wang, Yafei Cai, Jun Li
Summary: Spinal cord injury is a challenging clinical problem in neurosurgery, and cell apoptosis plays a crucial role in the secondary phase of injury. Inhibiting endoplasmic reticulum stress can alleviate cell death caused by spinal cord injury. Salubrinal, a fat-soluble compound, has been found to repair SCI by inhibiting ER stress.
Article
Biochemistry & Molecular Biology
Yurong Fu, Yongcheng Jin, Yue Tian, Hao Yu, Ruqi Wang, Huiyu Qi, Bo Feng, Jing Zhang
Summary: The synergistic effect of ZEA and LPS aggravates cytotoxicity by increasing the accumulation of ROS and MDA, decreasing MMP and SOD levels, and reducing GSH levels. Additionally, ZEA and LPS promote cell apoptosis by activating ER stress and suppressing anti-apoptotic proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Ke Du, Xi Zheng, Junya Lv, Xin Zhong, Minjie Wei, Mingyan Liu
Summary: The study showed that Cor exacerbates Cd-induced cognitive impairment and neurotoxicity in mice, induces synergistic growth inhibition and promotes apoptosis of SHSY5Y cells through the activation of endoplasmic reticulum (ER) stress. This suggests that Cor could enhance Cd-induced neurotoxicity by promoting ER stress-associated apoptosis, leading to potential implications for consumer safety and detection criteria for Cd in Cordyceps militaris.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Medicine, Research & Experimental
Yuxin Du, Laurie J. Demillard, Jun Ren
Summary: Cerebrovascular diseases such as stroke can lead to cardiac complications through mechanisms such as catecholamine surges, which increase the risk of heart damage.
Article
Marine & Freshwater Biology
Wei Hu, Qing-Ling Zhu, Jia-Lang Zheng, Zheng-Yong Wen
Summary: Exposure to cadmium led to growth inhibition, increased cadmium accumulation, oxidative stress, and other negative effects in fish. However, fish exhibited compensatory adaptive responses to resist cadmium toxicity. Genes involved in metabolic pathways were dysregulated by cadmium, potentially contributing to the toxicity.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Qiaoni Hu, Jifang Zheng, Xiao Na Xu, Chaohao Gu, Wanting Li
Summary: Uranium contamination induces excessive intracellular reactive oxygen species (ROS) generation, which is considered as a possible mediator of kidney tubular cells injury and nephrotoxicity. This study found that U exposure triggers endoplasmic reticulum stress, apoptosis, and down-regulation of PI3K/AKT/mTOR signaling. Administration of antioxidant N-acetylcysteine (NAC) effectively blocks ROS generation, ER stress, and apoptosis, and reverses the down-regulation of phosphorylated PI3K induced by U exposure.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Engineering, Environmental
Huanliang Liu, Wenqing Lai, Xiaohua Liu, Honglian Yang, Yanjun Fang, Lei Tian, Kang Li, Huipeng Nie, Wei Zhang, Yue Shi, Liping Bian, Susu Ding, Jun Yan, Bencheng Lin, Zhuge Xi
Summary: The research investigated the mechanism of hepatotoxicity and apoptosis caused by Nano-CuO through oxidative stress and ER-stress. Both in vivo and in vitro experiments confirmed that Nano-CuO induced oxidative stress, leading to ER-stress pathway activation and subsequently cell death.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Wenrong Feng, Shengyan Su, Changyou Song, Fan Yu, Jun Zhou, Jianlin Li, Rui Jia, Pao Xu, Yongkai Tang
Summary: High concentrations of copper pose a threat to aquatic animals, but the response mechanisms of crustaceans to Cu2+ exposure are not well understood. This study investigated the physiological and molecular changes in Chinese mitten crabs after Cu2+ exposure. The results showed that Cu2+ exposure decreased antioxidative capacity and promoted lipid peroxidation in different tissues. It also induced apoptosis and autophagy, and triggered an immune response. The toxicity of Cu2+ may be associated with the activation of ERK, AMPK, and TLR2-MyD88-NF-kappa B pathways.
Article
Endocrinology & Metabolism
Qiao Li, Yanyun Shen, Zhidong Zhu
Summary: Salubrinal alleviated atopic dermatitis induced by DNCB by suppressing inflammation, ER stress, and oxidative stress via attenuation of the NF-KB/NLRP3 axis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Environmental Sciences
Fu Cheng Yao, Yue Gu, Tian Jiang, Peng Fei Wang, Fei Biao Song, Zhi Zhou, Jun Long Sun, Jian Luo
Summary: Microplastics pollution is prevalent in coastal areas, posing a potential threat to marine organisms. In this study, the impact of polystyrene microplastics (PS-MPs) on Golden Pompano was investigated. The results showed that exposure to high concentrations of PS-MPs led to impaired growth, histopathological changes in the liver, oxidative stress, endoplasmic reticulum stress (ERS), apoptosis, metabolic alterations, and immune disturbance in the fish. These findings highlight the role of ERS in microplastics toxicology and reveal the adverse effects of microplastics on Golden Pompano.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Linjing Deng, Yongsheng Ma, Ping Ma, Yang Wu, Xu Yang, Qihong Deng
Summary: The study revealed that exposure to cooking oil fumes had significant toxic effects on the respiratory system of rats, including oxidative stress, activation of apoptosis factors, and endoplasmic reticulum stress. Vitamin E could effectively alleviate lung injury caused by exposure to cooking oil fumes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Matshediso Zachariah, Hatem Maamoun, Larissa Milano, Margaret P. Rayman, Lisiane B. Meira, Abdelali Agouni
Summary: Selenium is an essential trace element for human health, but a balanced intake is crucial for maximizing its health benefits. High selenium intake above physiological levels may increase diabetes risk and result in endothelial dysfunction. Selenium induces cancer cell apoptosis via endoplasmic reticulum stress, but its role in endothelial dysfunction remains unknown.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ting Xu, Jing Shuai, Zhiyuan Gu, Mengjie Wu
Summary: This study investigated the beneficial effects of intra-articular injection of Salubrinal on temporomandibular joint osteoarthritis (TMJOA) using a rabbit model of anterior disc displacement (ADD). The results showed that Salubrinal alleviated cartilage degradation following ADD, suggesting that it could be a potential therapeutic approach for preventing TMJOA.