HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

IL-15 Expands Unconventional CD8  NK1.1+ T Cells but Not V 14J 18+ NKT Cells

(2014) M. Terabe et al.   JOURNAL OF IMMUNOLOGY

Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8+ T Cells

(2014) D. V. Dolfi et al.   JOURNAL OF IMMUNOLOGY

Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin

(2013) Michael A. Curran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Co-Stimulation through 4-1BB/CD137 Improves the Expansion and Function of CD8+ Melanoma Tumor-Infiltrating Lymphocytes for Adoptive T-Cell Therapy

(2013) Jessica Ann Chacon et al.   PLoS One

An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine

(2013) Diana M. Alejo et al.   VACCINE

Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study)

(2012) A. Duerr et al.   JOURNAL OF INFECTIOUS DISEASES

Alternative Serotype Adenovirus Vaccine Vectors Elicit Memory T Cells with Enhanced Anamnestic Capacity Compared to Ad5 Vectors

(2012) Pablo Penaloza-MacMaster et al.   JOURNAL OF VIROLOGY

Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys

(2012) Dan H. Barouch et al.   NATURE

Decreased Pre-existing Ad5 Capsid and Ad35 Neutralizing Antibodies Increase HIV-1 Infection Risk in the Step Trial Independent of Vaccination

(2012) Cheng Cheng et al.   PLoS One

Heterologous Prime-Boost Regimens Using rAd35 and rMVA Vectors Elicit Stronger Cellular Immune Responses to HIV Proteins Than Homologous Regimens

(2012) Silvia Ratto-Kim et al.   PLoS One

A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge

(2012) Matthew R. Reynolds et al.   VACCINE

New Paradigms for HIV/AIDS Vaccine Development

(2011) Louis J. Picker et al.   Annual Review of Medicine

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

(2011) A. Palazon et al.   CANCER RESEARCH

Targeting HIV-1 Envelope Glycoprotein Trimers to B Cells by Using APRIL Improves Antibody Responses

(2011) M. Melchers et al.   JOURNAL OF VIROLOGY

Optimizing DC Vaccination by Combination With Oncolytic Adenovirus Coexpressing IL-12 and GM-CSF

(2011) Song-Nan Zhang et al.   MOLECULAR THERAPY

Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production

(2011) Michael A. Curran et al.   PLoS One

A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells

(2011) Mark Melchers et al.   Retrovirology

Incorporation of 4-1BB ligand into an adenovirus vaccine vector increases the number of functional antigen-specific CD8 T cells and enhances the duration of protection against influenza-induced respiratory disease

(2011) Theo J. Moraes et al.   VACCINE

DNA/Ad5 vaccination with SIV epitopes induced epitope-specific CD4+ T cells, but few subdominant epitope-specific CD8+ T cells

(2011) Lara Vojnov et al.   VACCINE

A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge

(2011) Devon J. Shedlock et al.   VACCINE

Focus and breadth of cellular immune responses elicited by a heterologous insert prime-boost vaccine regimen in rhesus monkeys

(2011) David R. Kaufman et al.   VACCINE

Soluble multi-trimeric TNF superfamily ligand adjuvants enhance immune responses to a HIV-1 Gag DNA vaccine

(2011) Saravana K. Kanagavelu et al.   VACCINE

Mucosal immunity in HIV controllers: the right place at the right time

(2011) Barbara L Shacklett et al.   Current Opinion in HIV and AIDS

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Development of TNFSF as molecular adjuvants for ALVAC HIV-1 vaccines

(2010) Jun Liu et al.   Human vaccines & immunotherapeutics

B-cell stage and context-dependent requirements for survival signals from BAFF and the B-cell receptor

(2010) Fabienne Mackay et al.   IMMUNOLOGICAL REVIEWS

Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice

(2010) Qing Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV vaccines: lessons learned and the way forward

(2010) Jerome H Kim et al.   Current Opinion in HIV and AIDS

Comparative ability of IL-12 and IL-28B to regulate Treg populations and enhance adaptive cellular immunity

(2009) M. P. Morrow et al.   BLOOD

GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo

(2009) R. W. van Olffen et al.   JOURNAL OF IMMUNOLOGY

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

Visualizing Antigen-Specific and Infected Cells in Situ Predicts Outcomes in Early Viral Infection

(2009) Q. Li et al.   SCIENCE

Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: Different effects on cellular and humoral immunity

(2009) Sumita Ganguly et al.   VACCINE

Safety and Immunogenicity of a Replication‐Incompetent Adenovirus Type 5 HIV‐1 Clade Bgag/pol/nefVaccine in Healthy Adults

(2008) Frances H. Priddy et al.   CLINICAL INFECTIOUS DISEASES

DNA gag/Adenovirus Type 5 (Ad5) gag and Ad5 gag/Ad5 gag Vaccines Induce Distinct T-Cell Response Profiles

(2008) K. S. Cox et al.   JOURNAL OF VIROLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

(2008) Jinyan Liu et al.   NATURE

Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice

(2008) Maria A. Croyle et al.   PLoS One

Toward an AIDS Vaccine

(2008) B. D. Walker et al.   SCIENCE

CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals

(2008) Jun Liu et al.   VACCINE